Search Results - "Ding, Yu‐Shin"

Serotonin and dopamine transporter PET changes in the premotor phase of LRRK2 parkinsonism: cross-sectional studies by Wile, Daryl J, Dr, Agarwal, Pankaj A, DM, Schulzer, Michael, Prof, Mak, Edwin, BASc, Dinelle, Katherine, MSc, Shahinfard, Elham, PhD, Vafai, Nasim, MASc, Hasegawa, Kazuko, PhD, Zhang, Jing, Prof, McKenzie, Jessamyn, LPN, Neilson, Nicole, RN, Strongosky, Audrey, BA, Uitti, Ryan J, Prof, Guttman, Mark, MD, Zabetian, Cyrus P, MD, Ding, Yu-Shin, Prof, Adam, Mike, PhD, Aasly, Jan, Prof, Wszolek, Zbigniew K, Prof, Farrer, Matthew, Prof, Sossi, Vesna, Prof, Stoessl, A Jon, Prof

“…Summary Background People with Parkinson's disease can show premotor neurochemical changes in the dopaminergic and non-dopaminergic systems. Using PET, we…”
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Endotoxin-induced systemic inflammation activates microglia: [11C]PBR28 positron emission tomography in nonhuman primates by Hannestad, Jonas, Gallezot, Jean-Dominique, Schafbauer, Thomas, Lim, Keunpoong, Kloczynski, Tracy, Morris, Evan D., Carson, Richard E., Ding, Yu-Shin, Cosgrove, Kelly P.

“…Microglia play an essential role in many brain diseases. Microglia are activated by local tissue damage or inflammation, but systemic inflammation can also…”
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Noradrenergic Activity in the Human Brain: A Mechanism Supporting the Defense Against Hypoglycemia by Belfort-DeAguiar, Renata, Gallezot, Jean-Dominique, Hwang, Janice J, Elshafie, Ahmed, Yeckel, Catherine W, Chan, Owen, Carson, Richard E, Ding, Yu-Shin, Sherwin, Robert S

“…Abstract Context Hypoglycemia, one of the major factors limiting optimal glycemic control in insulin-treated patients with diabetes, elicits a brain response…”
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Current Status of Hybrid PET/MRI in Oncologic Imaging by Rosenkrantz, Andrew B, Friedman, Kent, Chandarana, Hersh, Melsaether, Amy, Moy, Linda, Ding, Yu-Shin, Jhaveri, Komal, Beltran, Luis, Jain, Rajan

“…This review article explores recent advancements in PET/MRI for clinical oncologic imaging. Radiologists should understand the technical considerations that…”
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Normative database of the serotonergic system in healthy subjects using multi-tracer PET by Savli, Markus, Bauer, Andreas, Mitterhauser, Markus, Ding, Yu-Shin, Hahn, Andreas, Kroll, Tina, Neumeister, Alexander, Haeusler, Daniela, Ungersboeck, Johanna, Henry, Shannan, Isfahani, Sanaz Attaripour, Rattay, Frank, Wadsak, Wolfgang, Kasper, Siegfried, Lanzenberger, Rupert

“…The highly diverse serotonergic system with at least 16 different receptor subtypes is implicated in the pathophysiology of most neuropsychiatric disorders…”
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Clinically Relevant Doses of Methylphenidate Significantly Occupy Norepinephrine Transporters in Humans In Vivo by Hannestad, Jonas, Gallezot, Jean-Dominique, Planeta-Wilson, Beata, Lin, Shu-Fei, Williams, Wendol A, van Dyck, Christopher H, Malison, Robert T, Carson, Richard E, Ding, Yu-Shin

“…Background Attention-deficit/hyperactivity disorder is a psychiatric disorder that starts in childhood. The mechanism of action of methylphenidate, the most…”
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Affinity and selectivity of [11C]-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo by Gallezot, Jean-Dominique, Beaver, John D., Gunn, Roger N., Nabulsi, Nabeel, Weinzimmer, David, Singhal, Tarun, Slifstein, Mark, Fowles, Krista, Ding, Yu-Shin, Huang, Yiyun, Laruelle, Marc, Carson, Richard E., Rabiner, Eugenii A.

“…Although [11C]‐(+)‐PHNO has enabled quantification of the dopamine‐D3 receptor (D3R) in the human brain in vivo, its selectivity for the D3R is not…”
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PET imaging of the effects of age and cocaine on the norepinephrine transporter in the human brain using (S,S)-[11C]O-methylreboxetine and HRRT by Ding, Yu-Shin, Singhal, Tarun, Planeta-Wilson, Beata, Gallezot, Jean-Dominique, Nabulsi, Nabeel, Labaree, David, Ropchan, Jim, Henry, Shannan, Williams, Wendol, Carson, Richard E., Neumeister, Alexander, Malison, Robert T.

“…Objectives: The role of the norepinephrine transporter (NET) in cocaine dependence has never been demonstrated via in vivo imaging due to the lack of suitable…”
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Imaging the Effects of Methylphenidate on Brain Dopamine: New Model on Its Therapeutic Actions for Attention-Deficit/Hyperactivity Disorder by Volkow, Nora D., Wang, Gene-Jack, Fowler, Joanna S., Ding, Yu-Shin

“…Methylphenidate hydrochloride (MP) is an effective treatment for attention-deficit/hyperactivity disorder (ADHD), a common neurobehavioral disorder of…”
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Age-related changes in binding of the D2/3 receptor radioligand [11C](+)PHNO in healthy volunteers by Matuskey, David, Worhunksy, Patrick, Correa, Elizabeth, Pittman, Brian, Gallezot, Jean-Dominique, Nabulsi, Nabeel, Ropchan, Jim, Sreeram, Venkatesh, Gudepu, Rohit, Gaiser, Edward, Cosgrove, Kelly, Ding, Yu-Shin, Potenza, Marc N., Huang, Yiyun, Malison, Robert T., Carson, Richard E.

“…Previous imaging studies with positron emission tomography (PET) have reliably demonstrated an age-associated decline in the dopamine system. Most of these…”
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Noradrenaline transporter availability on [11C]MRB PET predicts weight loss success in highly obese adults by Vettermann, Franziska J., Rullmann, Michael, Becker, Georg A., Luthardt, Julia, Zientek, Franziska, Patt, Marianne, Meyer, Philipp M., McLeod, Anke, Brendel, Matthias, Blüher, Matthias, Stumvoll, Michael, Hilbert, Anja, Ding, Yu-Shin, Sabri, Osama, Hesse, Swen

“…Purpose Although the mechanisms by which the central noradrenaline (NA) system influences appetite and controls energy balance are quite well understood, its…”
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A scan without evidence is not evidence of absence: Scans without evidence of dopaminergic deficit in a symptomatic leucine-rich repeat kinase 2 mutation carrier by Wile, Daryl J., Dinelle, Katie, Vafai, Nasim, McKenzie, Jessamyn, Tsui, Joseph K., Schaffer, Paul, Ding, Yu-Shin, Farrer, Matthew, Sossi, Vesna, Stoessl, A. Jon

“…ABSTRACT Introduction The basis for SWEDD is unclear, with most cases representing PD mimics but some later developing PD with a dopaminergic deficit. Methods…”
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Cardiac sympathetic innervation and vesicular storage in pure autonomic failure by Goldstein, David S., Isonaka, Risa, Holmes, Courtney, Ding, Yu‐Shin, Sharabi, Yehonatan

“…Objective Pure autonomic failure (PAF) is a rare disease characterized by neurogenic orthostatic hypotension (nOH), absence of signs of central…”
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Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients by Li, Chiang-shan R., Morgan, Peter T., Matuskey, David, Abdelghany, Osama, Luo, Xi, Chang, Jeremy L. K., Rounsaville, Bruce J., Ding, Yu-shin, Malison, Robert T., Ito, Masao

“…Prior research points to the importance of psychostimulants in improving self-control. However, the neural substrates underlying such improvement remain…”
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PET imaging study of brown adipose tissue (BAT) activity in mice devoid of receptor for advanced glycation end products (RAGE) by Ding, Yu-Shin, Malik, Noeen, Mendoza, Sebastian, Tuchman, Daniel, Del Pozo, Carmen Hurtado, Diez, Raquel Lopez, Schmidt, Ann-Marie

“…Brown adipose tissue (BAT) is responsible for adaptive thermogenesis. We previously showed that genetic deficiency of receptor for advanced glycation end…”
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Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau by Banka, Vinay, Kelleher, Andrew, Sehlin, Dag, Hultqvist, Greta, Sigurdsson, Einar M., Syvänen, Stina, Ding, Yu-Shin

“…Introduction Alzheimer's disease (AD) is characterized by the misfolding and aggregation of two major proteins: amyloid-beta (Aβ) and tau. Antibody-based PET…”
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Synthesis and In Vitro and In Vivo Evaluation of [3H]LRRK2-IN-1 as a Novel Radioligand for LRRK2 by Malik, Noeen, Gifford, Andrew N, Sandell, Johan, Tuchman, Daniel, Ding, Yu-Shin

“…Purpose LRRK2 (leucine-rich repeat kinase 2) has recently been proven to be a promising drug target for Parkinson’s disease (PD) due to an apparent enhanced…”
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Central Serotonin/Noradrenaline Transporter Availability and Treatment Success in Patients with Obesity by Griebsch, Nora-Isabell, Kern, Johanna, Hansen, Jonas, Rullmann, Michael, Luthardt, Julia, Helfmeyer, Stephanie, Dekorsy, Franziska J, Soeder, Marvin, Hankir, Mohammed K, Zientek, Franziska, Becker, Georg-Alexander, Patt, Marianne, Meyer, Philipp M, Dietrich, Arne, Blüher, Matthias, Ding, Yu-Shin, Hilbert, Anja, Sabri, Osama, Hesse, Swen

“…Serotonin (5-hydroxytryptamine, 5-HT) as well as noradrenaline (NA) are key modulators of various fundamental brain functions including the control of…”
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Serotonin 1B Receptor Imaging in Alcohol Dependence by Hu, Jian, Henry, Shannan, Gallezot, Jean-Dominique, Ropchan, Jim, Neumaier, John F, Potenza, Marc N, Sinha, Rajita, Krystal, John H, Huang, Yiyun, Ding, Yu-Shin, Carson, Richard E, Neumeister, Alexander

“…Background Although animal models suggest that alcohol dependence (AD) is associated with elevations in the number of serotonin 1B receptors (5-HT1B R), 5-HT1B…”
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Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3‐Cl‐[11C]methylreboxetine and [18F]fluororeboxetine), (R)‐[11C]nisoxetine, [11C]oxaprotiline and [11C]lortalamine by Ding, Yu‐Shin, Lin, Kuo‐Shyan, Logan, Jean, Benveniste, Helene, Carter, Pauline

“…We have synthesized and evaluated several new ligands for imaging the norepinephrine transporter (NET) system in baboons with positron emission tomography…”
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