Search Results - "Dineen, Shauna M"

Coagulopathy signature precedes and predicts severity of end‐organ heat stroke pathology in a mouse model by Proctor, Elizabeth A., Dineen, Shauna M., Van Nostrand, Stephen C., Kuhn, Madison K., Barrett, Christopher D., Brubaker, Douglas K., Yaffe, Michael B., Lauffenburger, Douglas A., Leon, Lisa R.

“…Background Immune challenge is known to increase heat stroke risk, although the mechanism of this increased risk is unclear. Objectives We sought to understand…”
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Heat stroke activates a stress-induced cytokine response in skeletal muscle by Welc, Steven S, Clanton, Thomas L, Dineen, Shauna M, Leon, Lisa R

“…Heat stroke (HS) induces a rapid elevation in a number of circulating cytokines. This is often attributed to the stimulatory effects of endotoxin, released…”
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Assessing PreCR™ repair enzymes for restoration of STR profiles from artificially degraded DNA for human identification by Robertson, James M, Dineen, Shauna M, Scott, Kristina A, Lucyshyn, Jonathan, Saeed, Maria, Murphy, Devonie L, Schweighardt, Andrew J, Meiklejohn, Kelly A

“…Highlights • We evaluated the PreCR™ Repair Kit containing a suite of enzymes formulated to repair degraded DNA. • With artificially degraded purified-DNA and…”
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Prior viral illness increases heat stroke severity in mice by Dineen, Shauna M., Ward, Jermaine A., Leon, Lisa R.

“…New Findings What is the central question of this study? We hypothesized that prior illness would increase the susceptibility to and severity of heat stroke…”
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Evaluation of commercial RNA extraction kits for the isolation of viral MS2 RNA from soil by Dineen, Shauna M., Aranda, Roman, Dietz, Marianne E., Anders, Douglas L., Robertson, James M.

“…Nucleic acid extraction is a critical step in the detection of an unknown biological agent. However, success can vary depending on the isolation and…”
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Sex-dependent responses to exertional heat stroke in mice by Garcia, Christian K, Mattingly, Alex J, Robinson, Gerard P, Laitano, Orlando, King, Michelle A, Dineen, Shauna M, Leon, Lisa R, Clanton, Thomas L

“…With increasing participation of females in endurance athletics and active military service, it is important to determine if there are inherent sex-dependent…”
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Altered hypothalamic inflammatory gene expression correlates with heat stroke severity in a conscious rodent model by Audet, Gerald N, Dineen, Shauna M, Quinn, Carrie M, Leon, Lisa R

“…Abstract It has been suggested that heat-induced hypothalamic damage mediates core temperature ( Tc ) disturbances during heat stroke (HS) recovery; this is…”
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Pretreatment with indomethacin results in increased heat stroke severity during recovery in a rodent model of heat stroke by Audet, Gerald N, Dineen, Shauna M, Stewart, Delisha A, Plamper, Mark L, Pathmasiri, Wimal W, McRitchie, Susan L, Sumner, Susan J, Leon, Lisa R

“…It has been suggested that medications can increase heat stroke (HS) susceptibility/severity. We investigated whether the nonsteroidal anti-inflammatory drug…”
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Comparison and evaluation of RNA quantification methods using viral, prokaryotic, and eukaryotic RNA over a 10(4) concentration range by Aranda, 4th, Roman, Dineen, Shauna M, Craig, Rhonda L, Guerrieri, Richard A, Robertson, James M

“…Quantification of RNA is essential for various molecular biology studies. In this work, three quantification methods were evaluated: ultraviolet (UV)…”
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Comparison and evaluation of RNA quantification methods using viral, prokaryotic, and eukaryotic RNA over a 104 concentration range by Aranda, Roman, Dineen, Shauna M., Craig, Rhonda L., Guerrieri, Richard A., Robertson, James M.

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An Increase in Thermotolerance Is Associated with Elevated Levels of Heat Shock Protein 70 (HSP70) in a Mouse Exertional Heat Stroke Model by Dineen, Shauna M., Ward, Jermaine A., Plamper, Mark L., Mayer, Thomas A., Leon, Lisa R.

“…Abstract only Recent data from our laboratory showedthat one exertional heat stroke (EHS) exposure improved thermal tolerance inmice who were exposed to the…”
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Prior Viral Illness Exacerbates the Severity of Lung Injury in a Mice Heat Stroke Model by Plamper, Mark l., Dineen, Shauna M., King, Michelle A., Leon, Lisa R.

“…Heat Stroke (HS) is a common threatto both civilian and warfighter populations, however the mechanisms underlying tissueinjury are unknown. Acute respiratory…”
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Kidney Injury Marker‐1: A Potential Point‐of‐Care Biomarker of Heat Stress by Audet, Gerald N, Ward, Jermaine A, Dineen, Shauna M, Cheuvront, Samuel N, Leon, Lisa R

“…Abstract only Heat injury/stroke (HI/S) is a substantial threat to military operational readiness as well as athletic and occupational performance. There are…”
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Early Activation of Liver Apoptotic Signaling Pathways during Heat Stroke Recovery in Mice by Leon, Lisa R, Dineen, Shauna M., Clarke, David C.

“…Abstract only The inflammatory response to heat stroke (HS) often culminates in multi‐organ failure and death. Liver damage is a long‐term HS response but the…”
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Comparison and evaluation of RNA quantification methods using viral, prokaryotic, and eukaryotic RNA over a 10 4 concentration range by Aranda, Roman, Dineen, Shauna M., Craig, Rhonda L., Guerrieri, Richard A., Robertson, James M.

“…Quantification of RNA is essential for various molecular biology studies. In this work, three quantification methods were evaluated: ultraviolet (UV)…”
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