Search Results - "Dinan, T.G"

Kynurenine pathway metabolism and the microbiota-gut-brain axis by Kennedy, P.J., Cryan, J.F., Dinan, T.G., Clarke, G.

“…It has become increasingly clear that the gut microbiota influences not only gastrointestinal physiology but also central nervous system (CNS) function by…”
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Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression by Desbonnet, L, Garrett, L, Clarke, G, Kiely, B, Cryan, J.F, Dinan, T.G

“…Abstract The concept that intestinal microbial composition not only affects the health of the gut, but also influences centrally-mediated systems involved in…”
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Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle? by O’Mahony, S.M, Clarke, G, Dinan, T.G, Cryan, J.F

“…Highlights • Vulnerable neurodevelopmental windows exist during the life span. • Adverse events during these times include altered gut microbiota. • Increased…”
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Serotonin, tryptophan metabolism and the brain-gut-microbiome axis by O’Mahony, S.M., Clarke, G., Borre, Y.E., Dinan, T.G., Cryan, J.F.

“…•Serotonin is a key neurotransmitter in the brain-gut axis.•The gut microbiome is also critical to the normal functioning of the brain-gut axis.•Behaviour…”
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Bifidobacteria modulate cognitive processes in an anxious mouse strain by Savignac, H.M., Tramullas, M., Kiely, B., Dinan, T.G., Cryan, J.F.

“…•B. longum 1714 improves cognition in BALB/c mice.•B. breve 1205 had little or no positive effects on memory.•Neither of the bacteria had an effect on visceral…”
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Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats by O’Mahony, S.M, Felice, V.D, Nally, K, Savignac, H.M, Claesson, M.J, Scully, P, Woznicki, J, Hyland, N.P, Shanahan, F, Quigley, E.M, Marchesi, J.R, O’Toole, P.W, Dinan, T.G, Cryan, J.F

“…Highlights • Neonatal antibiotic treatment leads to an increase in visceral sensitivity in adulthood in rats. • Visceral hypersensitivity develops in the…”
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Behavioral and neurochemical consequences of chronic gut microbiota depletion during adulthood in the rat by Hoban, A.E, Moloney, R.D, Golubeva, A.V, McVey Neufeld, K.A, O’Sullivan, O, Patterson, E, Stanton, C, Dinan, T.G, Clarke, G, Cryan, J.F

“…Highlights • Chronic antibiotic treatment affects visceral pain and CNS monoamine levels. • Distinct behavioral profile after microbiota depletion. • No change…”
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Serum BDNF as a peripheral biomarker of treatment-resistant depression and the rapid antidepressant response: A comparison of ketamine and ECT by Allen, A.P, Naughton, M, Dowling, J, Walsh, A, Ismail, F, Shorten, G, Scott, L, McLoughlin, D.M, Cryan, J.F, Dinan, T.G, Clarke, G

“…Abstract Background Ketamine is associated with rapid antidepressant efficacy but the biological mechanisms underpinning this effect are unclear. Serum…”
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High-fat diet selectively protects against the effects of chronic social stress in the mouse by Finger, B.C, Dinan, T.G, Cryan, J.F

“…Abstract Obesity and stress-related psychiatric disorders are frequently comorbid. However, our understanding of the relationship between diet, everyday life…”
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Increased sensitivity to the effects of chronic social defeat stress in an innately anxious mouse strain by Savignac, H.M, Finger, B.C, Pizzo, R.C, O'Leary, O.F, Dinan, T.G, Cryan, J.F

“…Abstract Stress and genetic predisposition are two of the major risk factors for a variety of psychiatric illnesses. Inbred mouse strains are considered useful…”
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S.20.01 The microbiome-gut-brain axis: how bacteria can cause mood and psychotic disorders by Cryan, J.F, Dinan, T.G

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Region specific decrease in glial fibrillary acidic protein immunoreactivity in the brain of a rat model of depression by Gosselin, R.-D, Gibney, S, O'Malley, D, Dinan, T.G, Cryan, J.F

“…Abstract A growing body of evidence from human postmortem and animal studies suggests that deficits in glial cell (particularly astrocytes) density and…”
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Differential activation of the prefrontal cortex and amygdala following psychological stress and colorectal distension in the maternally separated rat by Felice, V.D, Gibney, S.M, Gosselin, R.D, Dinan, T.G, O’Mahony, S.M, Cryan, J.F

“…Highlights • Maternal separated (MS) animals have increased c-fos expression after CRD compared to NS rats in corticoamygdalar areas. • Increased c-fos…”
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Colorectal distension-induced prefrontal cortex activation in the Wistar–Kyoto rat: implications for irritable bowel syndrome by Gibney, S.M, Gosselin, R.-D, Dinan, T.G, Cryan, J.F

“…Abstract The prefrontal cortex plays a key role in the perception of painful stimuli, including those emerging from the viscera. Colorectal distension is a…”
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P.1.h.034 Epigenetic reversal of early-life stress-induced visceral hypersensitivity and anxiety behaviour by Moloney, R.D, Stilling, R.M, Dinan, T.G, Cryan, J.F

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Differential lipopolysaccharide-induced immune alterations in the hippocampus of two mouse strains: Effects of stress by Browne, C.A, O’Brien, F.E, Connor, T.J, Dinan, T.G, Cryan, J.F

“…Highlights ► Swim-stress attenuated LPS-induced increases in C57LB/6J hippocampal IL-1β mRNA. ► Hippocampal TNFα mRNA expression was significantly increased in…”
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A blend of dietary prebiotics and the probiotic LGG modulate behavioral and cognitive responses to maternal separation stress by Berg, B.M, Waworuntu, R.V, Neufeld, K.A. McVey, O’Mahony, S.M, Dinan, T.G, Cryan, J.F

“…Rodent maternal separation (MS) is a reliable model of early life stressed-induced alterations in behavior. The gut microbiota of MS rat pups differs from…”
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Lithium augmentation of the effects of desipramine in a mouse model of treatment-resistant depression: A role for hippocampal cell proliferation by O’Leary, O.F, Zandy, S, Dinan, T.G, Cryan, J.F

“…Highlights ► BALB/cOLaHsd mice do not respond to chronic desipramine treatment in the NIH. ► Addition of lithium to desipramine induced antidepressant-like…”
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Influence of GABA and GABA-producing Lactobacillus brevis DPC 6108 on the development of diabetes in a streptozotocin rat model by Marques, T M, Patterson, E, Wall, R, O'Sullivan, O, Fitzgerald, G F, Cotter, P D, Dinan, T G, Cryan, J F, Ross, R P, Stanton, C

“…The aim of this study was to investigate if dietary administration of γ-aminobutyric acid (GABA)-producing Lactobacillus brevis DPC 6108 and pure GABA exert…”
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Corrigendum to “Behavioural and neurochemical consequences of chronic gut microbiota depletion during adulthood in the rat” [Neuroscience 339 (2016) 463–477] by Hoban, A.E, Moloney, R.D, Golubeva, A.V, McVey Neufeld, K.A, O'Sullivan, O, Patterson, E, Stanton, C, Dinan, T.G, Clarke, G, Cryan, J.F

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