Search Results - "Din, Farhat V.N"

Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells by Din, Farhat V.N, Valanciute, Asta, Houde, Vanessa P, Zibrova, Daria, Green, Kevin A, Sakamoto, Kei, Alessi, Dario R, Dunlop, Malcolm G

“…Background & Aims Aspirin reduces the incidence of and mortality from colorectal cancer (CRC) by unknown mechanisms. Cancer cells have defects in signaling via…”
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Long term effect of surgery and radiotherapy for colorectal cancer on defecatory function and quality of life by Knowles, Gillian, Haigh, Rachel, McLean, Catriona, Phillips, Hamish A, Dunlop, Malcolm G, Din, Farhat V.N

“…Abstract Purpose Survival from rectal cancer has improved substantially. Understanding the consequences of treatment is important to optimise patient support…”
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Plasma Vitamin D Concentration Influences Survival Outcome After a Diagnosis of Colorectal Cancer by ZGAGA, Lina, THEODORATOU, Evropi, FARRINGTON, Susan M, DIN, Farhat V. N, LI YIN OOI, GLODZIK, Dominik, JOHNSTON, Susan, TENESA, Albert, CAMPBELL, Harry, DUNLOP, Malcolm G

“…We investigated whether the plasma level of 25-hydroxyvitamin D (25-OHD) after a diagnosis of colorectal cancer (CRC) influences survival outcome. We…”
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Colorectal cancer: management by Din, Farhat V.N, Dunlop, Malcolm G

“…Abstract Colorectal cancer is common with a lifetime risk of 5% and remains the second most common cause of cancer death with low 5-year survival (55%). Early…”
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Colorectal cancer: management by Din, Farhat V.N., Dunlop, Malcolm G.

“…Colorectal cancer is the fourth most common cause of cancer, contributing to 11% of all cancers, and the second most common cause of cancer death worldwide…”
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The effect of vitamin D supplementation on survival in patients with colorectal cancer: systematic review and meta-analysis of randomised controlled trials by Vaughan-Shaw, Peter G., Buijs, Louis F., Blackmur, James P., Theodoratou, Evi, Zgaga, Lina, Din, Farhat V. N., Farrington, Susan M., Dunlop, Malcolm G.

“…Background Low circulating vitamin D levels are associated with poor colorectal cancer (CRC) survival. We assess whether vitamin D supplementation improves CRC…”
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Author response to: Comment on: Double faecal immunochemical testing in patients with symptoms suspicious of colorectal cancer by Gerrard, Adam D, Dunlop, Malcolm G, Din, Farhat V N

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Colorectal cancer risk variants rs10161980 and rs7495132 are associated with cancer survival outcome by a recessive mode of inheritance by He, Yazhou, Timofeeva, Maria, Zhang, Xiaomeng, Xu, Wei, Li, Xue, Din, Farhat V. N., Svinti, Victoria, Farrington, Susan M., Campbell, Harry, Dunlop, Malcolm G., Theodoratou, Evropi

“…Previous studies using additive genetic models failed to identify robust evidence of associations between colorectal cancer (CRC) risk variants and survival…”
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Effect of aspirin and NSAIDs on risk and survival from colorectal cancer by Din, Farhat V N, Theodoratou, Evropi, Farrington, Susan M, Tenesa, Albert, Barnetson, Rebecca A, Cetnarskyj, Roseanne, Stark, Lesley, Porteous, Mary E, Campbell, Harry, Dunlop, Malcolm G

“…Previous studies have shown that aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) lower colorectal cancer (CRC) risk. However, the lowest…”
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Glycosylation of plasma IgG in colorectal cancer prognosis by Theodoratou, Evropi, Thaçi, Kujtim, Agakov, Felix, Timofeeva, Maria N., Štambuk, Jerko, Pučić-Baković, Maja, Vučković, Frano, Orchard, Peter, Agakova, Anna, Din, Farhat V. N., Brown, Ewan, Rudd, Pauline M., Farrington, Susan M., Dunlop, Malcolm G., Campbell, Harry, Lauc, Gordan

“…In this study we demonstrate the potential value of Immunoglobulin G (IgG) glycosylation as a novel prognostic biomarker of colorectal cancer (CRC). We…”
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Vitamin D treatment induces in vitro and ex vivo transcriptomic changes indicating anti‐tumor effects by Vaughan‐Shaw, Peter G., Blackmur, James P., Grimes, Graeme, Ooi, Li‐Yin, Ochocka‐Fox, Anna M., Dunbar, Karen, Kriegsheim, Alex, Rajasekaran, Vidya, Timofeeva, Maria, Walker, Marion, Svinti, Victoria, Din, Farhat V. N., Farrington, Susan M., Dunlop, Malcolm G.

“…Vitamin D deficiency is associated with risk of several common cancers, including colorectal cancer (CRC). Here we have utilized patient derived epithelial…”
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Distinguishing between direct and indirect consequences of covid-19 by Figueroa, Jonine D, Brennan, Paul M, Theodoratou, Evropi, Poon, Michael T C, Purshouse, Karin, Din, Farhat V N, Jin, Kai, Mesa-Eguiagaray, Ines, Dunlop, Malcolm G, Hall, Peter S, Cameron, David, Wild, Sarah H, Sudlow, Cathie L M

“…Lai and colleagues call for real time weekly data on cause specific mortality as these data are currently delayed in England, Wales, and Northern Ireland.12 In…”
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Short‐term outcomes of a COVID‐adapted triage pathway for colorectal cancer detection by Miller, Janice, Maeda, Yasuko, Au, Stephanie, Gunn, Frances, Porteous, Lorna, Pattenden, Rebecca, MacLean, Peter, Noble, Colin L., Glancy, Stephen, Dunlop, Malcolm G., Din, Farhat V. N.

“…Aim The dramatic curtailment of endoscopy and CT colonography capacity during the coronavirus pandemic has adversely impacted timely diagnosis of colorectal…”
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Differential genetic influences over colorectal cancer risk and gene expression in large bowel mucosa by Vaughan‐Shaw, Peter. G., Timofeeva, Maria, Ooi, Li‐Yin, Svinti, Victoria, Grimes, Graeme, Smillie, Claire, Blackmur, James P., Donnelly, Kevin, Theodoratou, Evi, Campbell, Harry, Zgaga, Lina, Din, Farhat V. N., Farrington, Susan M., Dunlop, Malcolm G.

“…Site‐specific variation in colorectal cancer (CRC) incidence, biology and prognosis are poorly understood. We sought to determine whether common genetic…”
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Effects of common genetic variants associated with colorectal cancer risk on survival outcomes after diagnosis: A large population‐based cohort study by He, Yazhou, Theodoratou, Evropi, Li, Xue, Din, Farhat V.N., Vaughan‐Shaw, Peter, Svinti, Victoria, Farrington, Susan M., Campbell, Harry, Dunlop, Malcolm G., Timofeeva, Maria

“…Genome‐wide association studies have thus far identified 130 genetic variants linked to colorectal cancer (CRC) risk (r2 < 0.2). Given their implication in…”
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Transcriptional dynamics of colorectal cancer risk associated variation at 11q23.1 correlate with tuft cell abundance and marker expression in silico by Harris, Bradley T., Rajasekaran, Vidya, Blackmur, James P., O’Callaghan, Alan, Donnelly, Kevin, Timofeeva, Maria, Vaughan-Shaw, Peter G., Din, Farhat V. N., Dunlop, Malcolm G., Farrington, Susan M.

“…Colorectal cancer (CRC) is characterised by heritable risk that is not well understood. Heritable, genetic variation at 11q23.1 is associated with increased…”
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A Comprehensive Study of the Effect on Colorectal Cancer Survival of Common Germline Genetic Variation Previously Linked with Cancer Prognosis by He, Yazhou, Timofeeva, Maria, Li, Xue, Din, Farhat V N, Blackmur, James P, Vaughan-Shaw, Peter, Svinti, Victoria, Farrington, Susan M, Campbell, Harry, Dunlop, Malcolm G, Theodoratou, Evropi

“…Germline genetic variants may influence pathways of tumor progression common to multiple cancer types. Here, we investigated the association between survival…”
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Urgent improvements needed to diagnose and manage Lynch syndrome by Monahan, Kevin J, Alsina, Deborah, Bach, Simon, Buchanan, James, Burn, John, Clark, Sue, Dawson, Peter, De Souza, Bianca, Din, Farhat V N, Dolwani, Sunil, Dunlop, Malcolm G, East, James, Evans, D Gareth, Fearnhead, Nicola, Frayling, Ian M, Glynne-Jones, Rob, Hill, James, Houlston, Richard, Hull, Mark, Lalloo, Fiona, Latchford, Andrew, Lishman, Suzy, Quirke, Phil, Rees, Colin, Rutter, Matt, Sasieni, Peter, Senapati, Asha, Speake, Doug, Thomas, Huw, Tomlinson, Ian

“…[...]a multifaceted and multimodel strategy is required to improve outcomes for people at high risk of colorectal cancer…”
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Instrumental variable estimation of the causal effect of plasma 25-hydroxy-vitamin D on colorectal cancer risk: a mendelian randomization analysis by Theodoratou, Evropi, Palmer, Tom, Zgaga, Lina, Farrington, Susan M, McKeigue, Paul, Din, Farhat V N, Tenesa, Albert, Davey-Smith, George, Dunlop, Malcolm G, Campbell, Harry

“…Vitamin D deficiency has been associated with several common diseases, including cancer and is being investigated as a possible risk factor for these…”
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Gene Co-Expression Network Analysis Identifies Vitamin D-Associated Gene Modules in Adult Normal Rectal Epithelium Following Supplementation by Blackmur, James P, Vaughan-Shaw, Peter G, Donnelly, Kevin, Harris, Bradley T, Svinti, Victoria, Ochocka-Fox, Anna-Maria, Freile, Paz, Walker, Marion, Gurran, Toby, Reid, Stuart, Semple, Colin A, Din, Farhat V N, Timofeeva, Maria, Dunlop, Malcolm G, Farrington, Susan M

“…Colorectal cancer (CRC) is a common, multifactorial disease. While observational studies have identified an association between lower vitamin D and higher CRC…”
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