Search Results - "Dimitri, Alexander"

Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editing by Dimitri, Alexander, Herbst, Friederike, Fraietta, Joseph A

“…Chimeric Antigen Receptor (CAR) T-cells represent a breakthrough in personalized cancer therapy. In this strategy, synthetic receptors comprised of antigen…”
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“From evidence to practice” – Insights from the multidisciplinary team on the optimal integration of GLP‐1 receptor agonists in obesity management services by Brown, Adrian, Mellor, Duane, Makaronidis, Janine, Shuttlewood, Emma, Miras, Alexander Dimitri, Pournaras, Dimitri J.

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Bariatric‐metabolic surgery for NHS patients with type 2 diabetes in the United Kingdom National Bariatric Surgery Registry by Currie, Andrew, Bolckmans, Roel, Askari, Alan, Byrne, James, Ahmed, Ahmed R., Batterham, Rachel L., Mahawar, Kamal, Miras, Alexander Dimitri, Pring, Chris M., Small, Peter K., Welbourn, Richard

“…Aim Bariatric‐metabolic surgery is approved by the National Institute of Health and Care Excellence (NICE) for people with severe obesity and type 2 diabetes…”
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Effect of Obesity Surgery on Taste by Al-Alsheikh, Alhanouf S, Alabdulkader, Shahd, Johnson, Brett, Goldstone, Anthony P, Miras, Alexander Dimitri

“…Obesity surgery is a highly efficacious treatment for obesity and its comorbidities. The underlying mechanisms of weight loss after obesity surgery are not yet…”
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Characteristics of Patients Lost to Follow-up after Bariatric Surgery by Krietenstein, Laura, Koschker, Ann-Cathrin, Miras, Alexander Dimitri, Kollmann, Lars, Gruber, Maximilian, Dischinger, Ulrich, Haubitz, Imme, Fassnacht, Martin, Warrings, Bodo, Seyfried, Florian

“…After bariatric surgery lifelong follow-up is recommended. Evidence of the consequences and reasons for being lost to follow-up (LTFU) is sparse. In this…”
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Candy cane revision after Roux-en-Y gastric bypass by Kamocka, Anna, McGlone, Emma Rose, Pérez-Pevida, Belén, Moorthy, Krishna, Hakky, Sherif, Tsironis, Christos, Chahal, Harvinder, Miras, Alexander Dimitri, Tan, Tricia, Purkayastha, Sanjay, Ahmed, Ahmed Rashid

“…Background An excessively long-blind end of the alimentary limb following a Roux-en-Y gastric bypass (RYGB), known as a ‘candy cane’ (CC), may cause symptoms…”
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Tracing Antibody Repertoire Evolution by Systems Phylogeny by Yermanos, Alexander Dimitri, Dounas, Andreas Kevin, Stadler, Tanja, Oxenius, Annette, Reddy, Sai T

“…Antibody evolution studies have been traditionally limited to either tracing a single clonal lineage (B cells derived from a single V-(D)-J recombination) over…”
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Clinical practice: chimeric antigen receptor (CAR) T cells: a major breakthrough in the battle against cancer by Lundh, Stefan, Jung, In-Young, Dimitri, Alexander, Vora, Anish, Melenhorst, J. Joseph, Jadlowsky, Julie K., Fraietta, Joseph A.

“…Chimeric antigen receptor (CAR) T cell therapy has come of age, offering a potentially curative option for patients who are refractory to standard anti-cancer…”
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Medication following bariatric surgery for type 2 diabetes mellitus (BY-PLUS) study: rationale and design of a randomised controlled study by Sudlow, Alexis, Miras, Alexander Dimitri, Cohen, Ricardo Vitor, Kahal, Hassan, Townley, Jill, Heneghan, Helen, Le Roux, Carel, Pournaras, Dimitri J

“…IntroductionBariatric surgery is an effective method of controlling glycaemia in patients with type 2 diabetes mellitus (T2DM) and obesity. Long-term studies…”
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TOX2 coordinates with TET2 to positively regulate central memory differentiation in human CAR T cells by Collins, Sierra M, Alexander, Katherine A, Lundh, Stefan, Dimitri, Alexander J, Zhang, Zhen, Good, Charly R, Fraietta, Joseph A, Berger, Shelley L

“…Chimeric antigen receptor (CAR) T cell therapy is used in treating human hematological malignancies, but its efficacy is limited by T cell exhaustion (T ). T…”
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Metabolomic Effects of Liraglutide Therapy on the Plasma Metabolomic Profile of Patients with Obesity by Alfadda, Assim A, Abdel Rahman, Anas M, Benabdelkamel, Hicham, AlMalki, Reem, Alsuwayni, Bashayr, Alhossan, Abdulaziz, Aldhwayan, Madhawi M, Abdeen, Ghalia N, Miras, Alexander Dimitri, Masood, Afshan

“…Liraglutide, a long-acting glucagon-like peptide-1 receptor agonist (GLP1RA), is a well-established anti-diabetic drug, has also been approved for the…”
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Does Bypass of the Proximal Small Intestine Impact Food Intake, Preference, and Taste Function in Humans? An Experimental Medicine Study Using the Duodenal-Jejunal Bypass Liner by Aldhwayan, Madhawi M, Al-Najim, Werd, Ruban, Aruchuna, Glaysher, Michael Alan, Johnson, Brett, Chhina, Navpreet, Dimitriadis, Georgios K, Prechtl, Christina Gabriele, Johnson, Nicholas A, Byrne, James Patrick, Goldstone, Anthony Peter, Teare, Julian P, Le Roux, Carel W, Miras, Alexander Dimitri

“…The duodenal-jejunal bypass liner (Endobarrier) is an endoscopic treatment for obesity and type 2 diabetes mellitus (T2DM). It creates exclusion of the…”
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Label-free quantitative proteomic profiling reveals differential plasma protein expression in patients with obesity after treatment with liraglutide by Masood, Afshan, Benabdelkamel, Hicham, Joy, Salini Scaria, Alhossan, Abdulaziz, Alsuwayni, Bashayr, Abdeen, Ghalia, Aldhwayan, Madhawi, Alfadda, Nora A, Miras, Alexander Dimitri, Alfadda, Assim A

“…Treatment and management of obesity is clinically challenging. The inclusion of GLP-1 receptor agonists (GLP1RA) in the medical management of obesity has…”
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Clinical characteristics of patients undergoing primary bariatric surgery in the United Kingdom based on the National Bariatric Surgery Registry by Bolckmans, Roel, Askari, Alan, Currie, Andrew, Ahmed, Ahmed R., Batterham, Rachel L., Byrne, James, Hopkins, James, Khan, Omar A., Mahawar, Kamal, Miras, Alexander Dimitri, Pring, Chris M., Small, Peter K., Welbourn, Richard

“…Summary Baseline demographic characteristics and operations undertaken for patients having bariatric surgery in the United Kingdom are largely unknown. This…”
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The implications of defining obesity as a disease: a report from the Association for the Study of Obesity 2021 annual conference by Luli, Migena, Yeo, Giles, Farrell, Emma, Ogden, Jane, Parretti, Helen, Frew, Emma, Bevan, Stephen, Brown, Adrian, Logue, Jennifer, Menon, Vinod, Isack, Nadya, Lean, Michael, McEwan, Chris, Gately, Paul, Williams, Simon, Astbury, Nerys, Bryant, Maria, Clare, Kenneth, Dimitriadis, Georgios K., Finlayson, Graham, Heslehurst, Nicola, Johnson, Brett, Le Brocq, Sarah, Roberts, Audrey, McGinley, Patrick, Mueller, Julia, O'Kane, Mary, Batterham, Rachel L., Roberts, Kath, Miras, Alexander Dimitri

“…Unlike various countries and organisations, including the World Health Organisation and the European Parliament, the United Kingdom does not formally recognise…”
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Discriminatory ability of anthropometric measurements of central fat distribution for prediction of post-prandial hyperglycaemia in patients with normal fasting glucose: the DICAMANO Study by Pérez-Pevida, Belén, Núñez-Córdoba, Jorge M, Romero, Sonia, Miras, Alexander Dimitri, Ibañez, Patricia, Vila, Neus, Margall, María Ángeles, Silva, Camilo, Salvador, Javier, Frühbeck, Gema, Escalada, Javier

“…Obesity is associated with impaired glucose tolerance which is a risk factor for cardiovascular risk. However, the oral glucose tolerance test (OGTT) is not…”
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O OUTRO LADO DA MOEDA: FRANCO CFA, COLONIZAÇÃO MONETÁRIA E NEOCOLONIALISMO by Bivar Ribeiro, Dimitri-Alexander Lenine, Kappes, Sylvio Antonio

“…O franco CFA, uma moeda criada para as colônias francesas da África, continua a ser utilizada até os dias de hoje em duas uniões monetárias, no centro e no…”
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A randomised controlled trial of a duodenal-jejunal bypass sleeve device (EndoBarrier) compared with standard medical therapy for the management of obese subjects with type 2 diabetes mellitus by Glaysher, Michael Alan, Mohanaruban, Aruchuna, Prechtl, Christina Gabriele, Goldstone, Anthony P, Miras, Alexander Dimitri, Lord, Joanne, Chhina, Navpreet, Falaschetti, Emanuela, Johnson, Nicholas Andrew, Al-Najim, Werd, Smith, Claire, Li, Jia V, Patel, Mayank, Ahmed, Ahmed R, Moore, Michael, Poulter, Neil, Bloom, Stephen, Darzi, Ara, Le Roux, Carel, Byrne, James P, Teare, Julian P

“…IntroductionThe prevalence of obesity and obesity-related diseases, including type 2 diabetes mellitus (T2DM), is increasing. Exclusion of the foregut, as…”
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Effectiveness of different recruitment strategies in an RCT of a surgical device: experience from the Endobarrier trial by Ruban, Aruchuna, Prechtl, Christina Gabriele, Glaysher, Michael Alan, Chhina, Navpreet, Al-Najim, Werd, Miras, Alexander Dimitri, Smith, Claire, P Goldstone, Anthony, Patel, Mayank, Moore, Michael, Ashrafian, Hutan, Byrne, James P, Teare, Julian P

“…Recruiting participants into clinical trials is notoriously difficult and poses the greatest challenge when planning any investigative study. Poor recruitment…”
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TET2 regulates early and late transitions in exhausted CD8 + T cell differentiation and limits CAR T cell function by Dimitri, Alexander J., Baxter, Amy E., Chen, Gregory M., Hopkins, Caitlin R., Rouin, Geoffrey T., Huang, Hua, Kong, Weimin, Holliday, Christopher H., Wiebking, Volker, Bartoszek, Robert, Drury, Sydney, Dalton, Katherine, Koucky, Owen M., Chen, Zeyu, Giles, Josephine R., Dils, Alexander T., Jung, In-Young, O’Connor, Roddy, Collins, Sierra, Everett, John K., Amses, Kevin, Sherrill-Mix, Scott, Chandra, Aditi, Goldman, Naomi, Vahedi, Golnaz, Jadlowsky, Julie K., Young, Regina M., Melenhorst, Jan Joseph, Maude, Shannon L., Levine, Bruce L., Frey, Noelle V., Berger, Shelley L., Grupp, Stephan A., Porter, David L., Herbst, Friederike, Porteus, Matthew H., Carty, Shannon A., Bushman, Frederic D., Weber, Evan W., Wherry, E. John, Jordan, Martha S., Fraietta, Joseph A.

“…CD8 + T cell exhaustion hampers control of cancer and chronic infections and limits chimeric antigen receptor (CAR) T cell efficacy. Targeting TET2 in CAR T…”
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