Search Results - "Dimberg, Anna"

Tumor angiogenesis: causes, consequences, challenges and opportunities by Lugano, Roberta, Ramachandran, Mohanraj, Dimberg, Anna

“…Tumor vascularization occurs through several distinct biological processes, which not only vary between tumor type and anatomic location, but also occur…”
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The glioblastoma vasculature as a target for cancer therapy by Dimberg, Anna

“…Glioblastoma is characterized by microvascular proliferation and a highly abnormal dysfunctional vasculature. The glioblastoma vessels differ significantly…”
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Vascular Targeting to Increase the Efficiency of Immune Checkpoint Blockade in Cancer by Georganaki, Maria, van Hooren, Luuk, Dimberg, Anna

“…Boosting natural immunity against malignant cells has had a major breakthrough in clinical cancer therapy. This is mainly due to the successful development of…”
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CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis by Lugano, Roberta, Vemuri, Kalyani, Yu, Di, Bergqvist, Michael, Smits, Anja, Essand, Magnus, Johansson, Staffan, Dejana, Elisabetta, Dimberg, Anna

“…Tumor angiogenesis occurs through regulation of genes that orchestrate endothelial sprouting and vessel maturation, including deposition of a vessel-associated…”
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Shaping the Tumor Stroma and Sparking Immune Activation by CD40 and 4-1BB Signaling Induced by an Armed Oncolytic Virus by Eriksson, Emma, Milenova, Ioanna, Wenthe, Jessica, Ståhle, Magnus, Leja-Jarblad, Justyna, Ullenhag, Gustav, Dimberg, Anna, Moreno, Raphael, Alemany, Ramon, Loskog, Angelica

“…Pancreatic cancer is a severe indication with short expected survival despite surgery and/or combination chemotherapeutics. Checkpoint blockade antibodies are…”
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Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy by Sun, Yi, Chen, Wei, Torphy, Robert J, Yao, Sheng, Zhu, Gefeng, Lin, Ronggui, Lugano, Roberta, Miller, Emily N, Fujiwara, Yuki, Bian, Li, Zheng, Linghua, Anand, Sudarshan, Gao, Fan, Zhang, Weizhou, Ferrara, Sarah E, Goodspeed, Andrew E, Dimberg, Anna, Wang, Xiao-Jing, Edil, Barish H, Barnett, Carlton C, Schulick, Richard D, Chen, Lieping, Zhu, Yuwen

“…The immature and dysfunctional vascular network within solid tumors poses a substantial obstacle to immunotherapy because it creates a hypoxic tumor…”
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Editorial: The blood-brain barrier in brain tumors: molecular mechanisms and therapeutic strategies by Zhang, Lei, Dimberg, Anna, Rasouli, Javad

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Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma by van Hooren, Luuk, Vaccaro, Alessandra, Ramachandran, Mohanraj, Vazaios, Konstantinos, Libard, Sylwia, van de Walle, Tiarne, Georganaki, Maria, Huang, Hua, Pietilä, Ilkka, Lau, Joey, Ulvmar, Maria H., Karlsson, Mikael C. I., Zetterling, Maria, Mangsbo, Sara M., Jakola, Asgeir S., Olsson Bontell, Thomas, Smits, Anja, Essand, Magnus, Dimberg, Anna

“…Gliomas are brain tumors characterized by an immunosuppressive microenvironment. Immunostimulatory agonistic CD40 antibodies (αCD40) are in clinical…”
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Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and antitumor immunity through eNOS/Src by Sjöberg, Elin, Melssen, Marit, Richards, Mark, Ding, Yindi, Chanoca, Catarina, Chen, Dongying, Nwadozi, Emmanuel, Pal, Sagnik, Love, Dominic T, Ninchoji, Takeshi, Shibuya, Masabumi, Simons, Michael, Dimberg, Anna, Claesson-Welsh, Lena

“…Endothelial phospholipase Cγ (PLCγ) is essential for vascular development; however, its role in healthy, mature, or pathological vessels is unexplored. Here,…”
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Complementarity-determining region clustering may cause CAR-T cell dysfunction by Sarén, Tina, Saronio, Giulia, Marti Torrell, Paula, Zhu, Xu, Thelander, Josefin, Andersson, Yasmin, Hofström, Camilla, Nestor, Marika, Dimberg, Anna, Persson, Helena, Ramachandran, Mohanraj, Yu, Di, Essand, Magnus

“…Chimeric antigen receptor (CAR)-T cell therapy is rapidly advancing as cancer treatment, however, designing an optimal CAR remains challenging. A single-chain…”
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Editorial: Tertiary Lymphoid Structures: From Basic Biology to Translational Impact in Cancer by Sautès-Fridman, Catherine, Dimberg, Anna, Verma, Vivek

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Of mice and lymphoid aggregates: modeling tertiary lymphoid structures in cancer by Vaccaro, Alessandra, van de Walle, Tiarne, Ramachandran, Mohanraj, Essand, Magnus, Dimberg, Anna

“…Tertiary lymphoid structures (TLS) are lymph node-like aggregates that can form in association with chronic inflammation or cancer. Mature TLS are organized…”
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CD93 Signaling via Rho Proteins Drives Cytoskeletal Remodeling in Spreading Endothelial Cells by Barbera, Stefano, Raucci, Luisa, Lugano, Roberta, Tosi, Gian Marco, Dimberg, Anna, Santucci, Annalisa, Galvagni, Federico, Orlandini, Maurizio

“…During angiogenesis, cell adhesion molecules expressed on the endothelial cell surface promote the growth and survival of newly forming vessels. Hence,…”
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Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis by Zhang, Yanyu, Cedervall, Jessica, Hamidi, Anahita, Herre, Melanie, Viitaniemi, Kati, D'Amico, Gabriela, Miao, Zuoxiu, Unnithan, Ragaseema Valsala Madhavan, Vaccaro, Alessandra, van Hooren, Luuk, Georganaki, Maria, Thulin, Åsa, Qiao, Qi, Andrae, Johanna, Siegbahn, Agneta, Heldin, Carl-Henrik, Alitalo, Kari, Betsholtz, Christer, Dimberg, Anna, Olsson, Anna-Karin

“…Platelet-derived growth factor B (PDGFB) plays a crucial role in recruitment of PDGF receptor β-positive pericytes to blood vessels. The endothelium is an…”
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Tertiary Lymphoid Structures in the Central Nervous System: Implications for Glioblastoma by van de Walle, Tiarne, Vaccaro, Alessandra, Ramachandran, Mohanraj, Pietilä, Ilkka, Essand, Magnus, Dimberg, Anna

“…Glioblastoma is the most common and aggressive brain tumor, which is uniformly lethal due to its extreme invasiveness and the absence of curative therapies…”
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Author Correction: A method for Boolean analysis of protein interactions at a molecular level by Raykova, Doroteya, Kermpatsou, Despoina, Malmqvist, Tony, Harrison, Philip J., Sander, Marie Rubin, Stiller, Christiane, Heldin, Johan, Leino, Mattias, Ricardo, Sara, Klemm, Anna, David, Leonor, Spjuth, Ola, Vemuri, Kalyani, Dimberg, Anna, Sundqvist, Anders, Norlin, Maria, Klaesson, Axel, Kampf, Caroline, Söderberg, Ola

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Tumor endothelial ELTD1 as a predictive marker for treatment of renal cancer patients with sunitinib by Niinivirta, Marjut, Georganaki, Maria, Enblad, Gunilla, Lindskog, Cecilia, Dimberg, Anna, Ullenhag, Gustav J

“…Patients with metastatic renal cell cancer (mRCC) are commonly treated with the tyrosine kinase inhibitor sunitinib, which blocks signalling from vascular…”
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A method for Boolean analysis of protein interactions at a molecular level by Raykova, Doroteya, Kermpatsou, Despoina, Malmqvist, Tony, Harrison, Philip J., Sander, Marie Rubin, Stiller, Christiane, Heldin, Johan, Leino, Mattias, Ricardo, Sara, Klemm, Anna, David, Leonor, Spjuth, Ola, Vemuri, Kalyani, Dimberg, Anna, Sundqvist, Anders, Norlin, Maria, Klaesson, Axel, Kampf, Caroline, Söderberg, Ola

“…Determining the levels of protein–protein interactions is essential for the analysis of signaling within the cell, characterization of mutation effects,…”
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Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing by Xie, Yuan, He, Liqun, Lugano, Roberta, Zhang, Yanyu, Cao, Haiyan, He, Qiyuan, Chao, Min, Liu, Boxuan, Cao, Qingze, Wang, Jianhao, Jiao, Yang, Hu, Yaqin, Han, Liying, Zhang, Yong, Huang, Hua, Uhrbom, Lene, Betsholtz, Christer, Wang, Liang, Dimberg, Anna, Zhang, Lei

“…Passage of systemically delivered pharmacological agents into the brain is largely blocked by the blood-brain-barrier (BBB), an organotypic specialization of…”
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Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization by Dieterich, Lothar C, Mellberg, Sofie, Langenkamp, Elise, Zhang, Lei, Zieba, Agata, Salomäki, Henriikka, Teichert, Martin, Huang, Hua, Edqvist, Per-Henrik, Kraus, Theo, Augustin, Hellmut G, Olofsson, Tommie, Larsson, Erik, Söderberg, Ola, Molema, Grietje, Pontén, Fredrik, Georgii-Hemming, Patrik, Alafuzoff, Irina, Dimberg, Anna

“…Glioblastoma are aggressive astrocytic brain tumours characterized by microvascular proliferation and an abnormal vasculature, giving rise to brain oedema and…”
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