Technetium-99M Pertechnetate Disappearance Studies in Normal and Psoriatic Skin

Technetium-99M Pertechnetate Disappearance Studies in Normal and Psoriatic Skin

A method has been presented which has proved reliable and reproducible (in two groups of 6 subjects) in monitoring cutaneous vascular function or tracer diffusion from an injection site. The method is based on intradermal injection of Technetium- 99m pertechnetate and recording disappearance of the...

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Bibliographic Details
Published in:Journal of investigative dermatology Vol. 56; no. 1; pp. 39 - 43
Main Authors: Dilorenzo, Pasquale A., Brown, Donald W., Walker, Strother H., Dern, Philip L., Goltz, Robert W.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-01-1971
Subjects:
Adolescent
Adult
Aged
Computers
Female
Half-Life
Humans
Injections, Intradermal
Male
Methods
Middle Aged
Psoriasis - drug therapy
Psoriasis - physiopathology
Radioisotope Dilution Technique
Radioisotope Renography - instrumentation
Regional Blood Flow
Skin - blood supply
Technetium
Time Factors
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Summary:A method has been presented which has proved reliable and reproducible (in two groups of 6 subjects) in monitoring cutaneous vascular function or tracer diffusion from an injection site. The method is based on intradermal injection of Technetium- 99m pertechnetate and recording disappearance of the isotope continuously with a standard renogram recording system. Standardized computer routines evaluate each record, summarizing the information by determining a half-time for the subject and site. The standard deviation of experimental error in our method is approximately one minute. Within that limit we find that right and left half-times at symmetric uninvolved locations are indistinguishable. Further, the average disappearance hall-time from lesions in a group of psoriatics will be less, by about 3.5 minutes, than the average disappearance half-time from uninvolved symmetric sites in the same patients. We believe that the data presented on normal and pathological disappearance rates contribute to understanding skin pathology. We also believe that our method will provide an objective basis for evaluation and comparison of drug effects in groups of patients. The method itself is suitable for application in further study of this subject.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0022-202X
1523-1747
DOI:10.1111/1523-1747.ep12291896