Anti-skin ageing activity of napthoquinones from Arnebia nobilis Reichb.f

The present isolation and identification of napthoquinones from roots of Arnebia nobilis Reichb.f. can lead to the discovery of new anti-skin ageing ingredient in colour cosmetics. Four compounds have been isolated and purified by rigorous column chromatography. The compounds are identified as β, β-...

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Bibliographic Details
Published in:	Natural product research Vol. 30; no. 5; pp. 574 - 577
Main Authors:	Mohapatra, Satyabrata, Sandeep Varma, R, Sharath Kumar, L.M, Thiyagarajan, O.S, Vijaykumar, M, Dilmel, K, Nishant, M, Babu, U.V, Patki, P.S
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 01-01-2016
Subjects:	alkannins Animals Arnebia nobilis blood Boraginaceae - chemistry cell senescence cellular senescence Cellular Senescence - drug effects chromatography Collagen Type I - biosynthesis color colour cosmetics Cosmetics elastin Elastin - biosynthesis fibroblasts Fibroblasts - drug effects hemolysis Hemolysis - drug effects Humans hydrogen peroxide Hydrogen Peroxide - antagonists & inhibitors ingredients inhibitory concentration 50 keratinocytes Keratinocytes - drug effects Keratinocytes - metabolism Mice Naphthoquinones - isolation & purification Naphthoquinones - pharmacology NIH 3T3 Cells Plant Roots - chemistry Protein Precursors - biosynthesis roots Skin Aging - drug effects skin barrier spectral analysis Up-Regulation - drug effects skin barrier alkannins Arnebia nobilis cellular senescence colour cosmetics
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Summary:	The present isolation and identification of napthoquinones from roots of Arnebia nobilis Reichb.f. can lead to the discovery of new anti-skin ageing ingredient in colour cosmetics. Four compounds have been isolated and purified by rigorous column chromatography. The compounds are identified as β, β-dimethylacryl alkannin (AN-I), acetoxyisovaleryl alkannin (AAN-II), acetyl alkannin (AN-III) and alkannin (AN-IV) by interpretation of spectroscopic data. This study is the first to report the isolation of Acetoxyisovaleryl alkannin (AAN-II) from A. nobilis . The IC ₅₀ values of the compounds, determined in human skin cells (human dermal fibroblasts and human keratinocytes) and mouse embryonic fibroblasts (NIH3T3) varied significantly among the four alkannins. Among the four compounds, β-acetoxyisovaleryl alkannin (AAN-II) significantly inhibited hydrogen peroxide (H ₂O ₂)-induced red blood corpuscle haemolysis and cellular senescence in human dermal fibroblasts. Collagen-I, elastin and involucrin syntheses in human dermal fibroblasts or keratinocytes were up regulated by AAN-II. These results support the potential utility of alkannins as novel anti-ageing ingredients.
Bibliography:	http://dx.doi.org/10.1080/14786419.2015.1025232 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1478-6427 1478-6419 1478-6427
DOI:	10.1080/14786419.2015.1025232