Search Results - "Dillon, Thomas"

Characterization of therapeutic proteins by cation exchange chromatography-mass spectrometry and top-down analysis by Shi, Rachel Liuqing, Xiao, Gang, Dillon, Thomas M, Ricci, Margaret S, Bondarenko, Pavel V

“…Recently, cation exchange chromatography (CEX) using aqueous volatile buffers was directly coupled with mass spectrometry (MS) and applied for intact analysis…”
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Native SEC and Reversed-Phase LC–MS Reveal Impact of Fab Glycosylation of Anti-SARS-COV‑2 Antibodies on Binding to the Receptor Binding Domain by Woodall, Daniel W., Thomson, Christy A., Dillon, Thomas M., McAuley, Arnold, Green, Lydia B., Foltz, Ian N., Bondarenko, Pavel V.

“…The binding affinity of monoclonal antibodies (mAbs) for their intended therapeutic targets is often affected by chemical and post-translational modifications…”
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Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro by Alimova, Irina N., Liu, Bolin, Fan, Zeying, Edgerton, Susan M., Dillon, Thomas, Lind, Stuart E., Thor, Ann D.

“…The anti-diabetic drug metformin reduces human cancer incidence and improves the survival of cancer patients, including those with breast cancer. We studied…”
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Structural and Functional Characterization of Disulfide Isoforms of the Human IgG2 Subclass by Dillon, Thomas M., Ricci, Margaret Speed, Vezina, Chris, Flynn, Gregory C., Liu, Yaoqing Diana, Rehder, Douglas S., Plant, Matthew, Henkle, Brad, Li, Yu, Deechongkit, Songpon, Varnum, Brian, Wypych, Jette, Balland, Alain, Bondarenko, Pavel V.

“…In the accompanying report (Wypych, J., Li, M., Guo, A., Zhang, Z., Martinez, T., Allen, M. J., Fodor, S., Kelner, D. N., Flynn, G. C., Liu, Y. D., Bondarenko,…”
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Human IgG2 Antibodies Display Disulfide-mediated Structural Isoforms by Wypych, Jette, Li, Ming, Guo, Amy, Zhang, Zhongqi, Martinez, Theresa, Allen, Martin J., Fodor, Szilan, Kelner, Drew N., Flynn, Gregory C., Liu, Yaoqing Diana, Bondarenko, Pavel V., Ricci, Margaret Speed, Dillon, Thomas M., Balland, Alain

“…In this work, we present studies of the covalent structure of human IgG2 molecules. Detailed analysis showed that recombinant human IgG2 monoclonal antibody…”
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The microbiome of an outpatient rehabilitation clinic and predictors of contamination: A pilot study by Brigando, Gabriella, Sutton, Casey, Uebelhor, Olivia, Pitsoulakis, Nicholas, Pytynia, Matthew, Dillon, Thomas, Elliott-Burke, Teresa, Hubert, Nathaniel, Martinez-Guryn, Kristina, Bolch, Charlotte, Ciancio, Mae J, Evans, Christian C

“…Understanding sources of microbial contamination in outpatient rehabilitation (REHAB) clinics is important to patients and healthcare providers. The purpose of…”
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Non-targeted characterization of attributes affecting antibody-FcγRIIIa V158 (CD16a) binding via online affinity chromatography-mass spectrometry by Woodall, Daniel W, Dillon, Thomas M, Kalenian, Kevin, Padaki, Rupa, Kuhns, Scott, Semin, David J, Bondarenko, Pavel V

“…Antibodies facilitate targeted cell killing by engaging with immune cells such as natural killer cells through weak binding interactions with Fcγ receptors on…”
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Cement and concrete decarbonisation roadmaps – a meta-analysis within the context of the United Kingdom by Marsh, Alastair, Dillon, Thomas, Bernal, Susan

“…Decarbonisation is the most urgent issue facing the cement and concrete industries, with an aim to reach net-zero carbon dioxide emissions by 2050. In response…”
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Identification of critical chemical modifications by size exclusion chromatography of stressed antibody-target complexes with competitive binding by Shi, Rachel Liuqing, Xiao, Gang, Dillon, Thomas M, McAuley, Arnold, Ricci, Margaret S, Bondarenko, Pavel V

“…Chemical modifications (attributes) in the binding regions of stressed therapeutic proteins may affect binding to target and efficacy of therapeutic proteins…”
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Examining the effectiveness of psychological interventions for marginalised and disadvantaged women and individuals who have experienced gender-based violence: protocol for a scoping review by Yalcinoz-Ucan, Busra, Zilney, Laura, Zientarska-Kayko, Agnes, Ireland, Timothy, Browne, Dillon Thomas

“…IntroductionExposure to gender-based violence (GBV) has devastating psychological outcomes for victims/survivors. Particularly in conditions where GBV…”
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Random-Coil Behavior and the Dimensions of Chemically Unfolded Proteins by Kohn, Jonathan E., Millett, Ian S., Jacob, Jaby, Zagrovic, Bojan, Dillon, Thomas M., Cingel, Nikolina, Dothager, Robin S., Seifert, Soenke, Thiyagarajan, P., Sosnick, Tobin R., Hasan, M. Zahid, Pande, Vijay S., Ruczinski, Ingo, Doniach, Sebastian, Plaxco, Kevin W., Baldwin, Robert L.

“…Spectroscopic studies have identified a number of proteins that appear to retain significant residual structure under even strongly denaturing conditions…”
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Identification of critical chemical modifications and paratope mapping by size exclusion chromatography of stressed antibody-target complexes by Bondarenko, Pavel, Nichols, Andrew C, Xiao, Gang, Shi, Rachel Liuqing, Chan, Pik Kay, Dillon, Thomas M, Garces, Fernando, Semin, David J, Ricci, Margaret S

“…Therapeutic proteins including antibodies and Fc-fusion proteins undergo a large number of chemical modifications during cell culture, purification, storage…”
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Optimization of a reversed-phase high-performance liquid chromatography/mass spectrometry method for characterizing recombinant antibody heterogeneity and stability by Dillon, Thomas M., Bondarenko, Pavel V., Rehder, Douglas S., Pipes, Gary D., Kleemann, Gerd R., Ricci, Margaret Speed

“…An enhanced analytical RP-HPLC/MS method was developed for monitoring the stability and production of intact and fragmented monoclonal antibodies (MAbs). The…”
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Conformational implications of an inversed pH-dependent antibody aggregation by Perico, Natalie, Purtell, Judith, Dillon, Thomas M, Ricci, Margaret S

“…Antibody formulation development relies on accelerated stability data at elevated temperatures to optimize formulation parameters. However, the pH- and…”
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Isomerization of a Single Aspartyl Residue of Anti-Epidermal Growth Factor Receptor Immunoglobulin γ2 Antibody Highlights the Role Avidity Plays in Antibody Activity by Rehder, Douglas S, Chelius, Dirk, McAuley, Arnold, Dillon, Thomas M, Xiao, Gang, Crouse-Zeineddini, Jill, Vardanyan, Louisa, Perico, Natalie, Mukku, Venkat, Brems, David N, Matsumura, Masazumi, Bondarenko, Pavel V

“…A new isoform of the light chain of a fully human monoclonal immunoglobulin γ2 (IgG2) antibody panitumumab against human epidermal growth factor receptor…”
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From screen time to the digital level of analysis: a scoping review of measures for digital media use in children and adolescents by Browne, Dillon Thomas, May, Shealyn S, Colucci, Laura, Hurst-Della Pietra, Pamela, Christakis, Dimitri, Asamoah, Tracy, Hale, Lauren, Delrahim-Howlett, Katia, Emond, Jennifer A, Fiks, Alexander G, Madigan, Sheri, Perlman, Greg, Rumpf, Hans-Jürgen, Thompson, Darcy, Uzzo, Stephen, Stapleton, Jackie, Neville, Ross, Prime, Heather

“…ObjectivesThis scoping review aims to facilitate psychometric developments in the field of digital media usage and well-being in young people by (1)…”
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Formation of Pyroglutamic Acid from N-Terminal Glutamic Acid in Immunoglobulin Gamma Antibodies by Chelius, Dirk, Jing, Kay, Lueras, Alexis, Rehder, Douglas S, Dillon, Thomas M, Vizel, Alona, Rajan, Rahul S, Li, Tiansheng, Treuheit, Michael J, Bondarenko, Pavel V

“…The status of the N-terminus of proteins is important for amino acid sequencing by Edman degradation, protein identification by shotgun and top-down…”
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Impact of antibody subclass and disulfide isoform differences on the biological activity of CD200R and βklotho agonist antibodies by Grujic, Ognjen, Stevens, Jennitte, Chou, Robert Y.-T., Weiszmann, Jennifer V., Sekirov, Laura, Thomson, Christy, Badh, Anita, Grauer, Stephanie, Chan, Brian, Graham, Kevin, Manchulenko, Kathy, Dillon, Thomas M., Li, Yang, Foltz, Ian N.

“…Agonism of cell surface receptors by monoclonal antibodies is dependent not only on its ability to bind the target, but also to deliver a biological signal…”
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Reversed-phase liquid chromatography/mass spectrometry analysis of reduced monoclonal antibodies in pharmaceutics by Rehder, Douglas S., Dillon, Thomas M., Pipes, Gary D., Bondarenko, Pavel V.

“…A reversed-phase LC/MS method was developed for reduced antibodies that provides efficient separation of light chain and two variants of heavy chain containing…”
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Identification of cysteinylation of a free cysteine in the Fab region of a recombinant monoclonal IgG1 antibody using Lys-C limited proteolysis coupled with LC/MS analysis by Gadgil, Himanshu S., Bondarenko, Pavel V., Pipes, Gary D., Dillon, Thomas M., Banks, Douglas, Abel, Jeffrey, Kleemann, Gerd R., Treuheit, Michael J.

“…MAB007, an IgG1 monoclonal antibody, is unique because of the presence of a free cysteine residue in the Fab region at position 104 on the heavy chain in the…”
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