Search Results - "Dillon, Stacey R"

A sensory neuron–expressed IL-31 receptor mediates T helper cell–dependent itch: Involvement of TRPV1 and TRPA1 by Cevikbas, Ferda, PhD, Wang, Xidao, PhD, Akiyama, Tasuku, PhD, Kempkes, Cordula, PhD, Savinko, Terhi, PhD, Antal, Attila, MD, Kukova, Gabriela, MD, Buhl, Timo, MD, Ikoma, Akihiko, MD, PhD, Buddenkotte, Joerg, PhD, Soumelis, Vassili, MD, Feld, Micha, PhD, Alenius, Harri, PhD, Dillon, Stacey R., PhD, Carstens, Earl, PhD, Homey, Bernhard, MD, Basbaum, Allan, PhD, Steinhoff, Martin, MD, PhD

“…Background Although the cytokine IL-31 has been implicated in inflammatory and lymphoma-associated itch, the cellular basis for its pruritic action is yet…”
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The pruritus- and TH2-associated cytokine IL-31 promotes growth of sensory nerves by Feld, Micha, Garcia, Richard, Buddenkotte, Jörg, Katayama, Shintaro, Lewis, Katherine, Muirhead, Gareth, Hevezi, Peter, Plesser, Kristin, Schrumpf, Holger, Krjutskov, Kaarel, Sergeeva, Olga, Müller, Hans Werner, Tsoka, Sophia, Kere, Juha, Dillon, Stacey R, Steinhoff, Martin, Homey, Bernhard

“…Pruritus is a cardinal symptom of atopic dermatitis, and an increased cutaneous sensory network is thought to contribute to pruritus. Although the immune…”
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RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications by Suárez-Fariñas, Mayte, PhD, Ungar, Benjamin, BA, Correa da Rosa, Joel, PhD, Ewald, David A., MSc, Rozenblit, Mariya, BA, Gonzalez, Juana, PhD, Xu, Hui, MSc, Zheng, Xiuzhong, MSc, Peng, Xiangyu, MSc, Estrada, Yeriel D., MSc, Dillon, Stacey R., PhD, Krueger, James G., MD, PhD, Guttman-Yassky, Emma, MD, PhD

“…Background Genomic profiling of lesional and nonlesional skin of patients with atopic dermatitis (AD) using microarrays has led to increased understanding of…”
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Cutting Edge: The Dependence of Plasma Cells and Independence of Memory B Cells on BAFF and APRIL by Benson, Micah J, Dillon, Stacey R, Castigli, Emanuela, Geha, Raif S, Xu, Shengli, Lam, Kong-Peng, Noelle, Randolph J

“…Memory B (B(MEM)) cells and long-lived bone marrow plasma cells (BM-PCs) persist within local environmental survival niches that afford cellular longevity…”
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IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function by Singh, Brijendra, Jegga, Anil G, Shanmukhappa, Kumar S, Edukulla, Ramakrishna, Khurana Hershey, Gurjit H, Medvedovic, Mario, Dillon, Stacey R, Madala, Satish K

“…Interleukin-31 (IL-31) is a type 2 helper T-cell-derived cytokine that has recently been shown to cause severe inflammation and tissue remodeling in multiple…”
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The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity by Maurer, Mark F., Lewis, Katherine E., Kuijper, Joseph L., Ardourel, Dan, Gudgeon, Chelsea J., Chandrasekaran, Siddarth, Mudri, Sherri L., Kleist, Kayla N., Navas, Chris, Wolfson, Martin F., Rixon, Mark W., Swanson, Ryan, Dillon, Stacey R., Levin, Steven D., Kimbung, Yengo Raymond, Akutsu, Masato, Logan, Derek T., Walse, Björn, Swiderek, Kristine M., Peng, Stanford L.

“…Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective…”
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Acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models by Orvain, Cindy, Cauvet, Anne, Prudent, Alexis, Guignabert, Christophe, Thuillet, Raphaël, Ottaviani, Mina, Tu, Ly, Duhalde, Fanny, Nicco, Carole, Batteux, Frédéric, Avouac, Jérôme, Wang, NingXin, Seaberg, Michelle A, Dillon, Stacey R, Allanore, Yannick

“…Uncontrolled immune response with T cell activation has a key role in the pathogenesis of systemic sclerosis (SSc), a disorder that is characterized by…”
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Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models by Lewis, Katherine E., Selby, Mark J., Masters, Gregg, Valle, Jose, Dito, Gennaro, Curtis, Wendy R., Garcia, Richard, Mink, Kathy A., Waggie, Kimberly S., Holdren, Matthew S., Grosso, Joseph F., Korman, Alan J., Jure-Kunkel, Maria, Dillon, Stacey R.

“…Recent advances in cancer treatment with checkpoint blockade of receptors such as CTLA-4 and PD-1 have demonstrated that combinations of agents with…”
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Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL by Chiu, April, Xu, Weifeng, He, Bing, Dillon, Stacey R., Gross, Jane A., Sievers, Eric, Qiao, Xugang, Santini, Paul, Hyjek, Elizabeth, Lee, Joong-won, Cesarman, Ethel, Chadburn, Amy, Knowles, Daniel M., Cerutti, Andrea

“…Hodgkin lymphoma (HL) originates from the clonal expansion of malignant Hodgkin and Reed-Sternberg (HRS) cells. These B-cell–derived elements constitute less…”
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Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes by Hippen, Keli L., Bucher, Christoph, Schirm, Dawn K., Bearl, Amanda M., Brender, Ty, Mink, Kathy A., Waggie, Kimberly S., Peffault de Latour, Regis, Janin, Anne, Curtsinger, Julie M., Dillon, Stacey R., Miller, Jeffrey S., Socie, Gerard, Blazar, Bruce R.

“…In rodent graft-versus-host disease (GVHD) models, anti–IL-21 neutralizing mAb treatment ameliorates lethality and is associated with decreases in Th1 cytokine…”
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IL-31 receptor (IL-31RA) knockout mice exhibit elevated responsiveness to oncostatin M by Bilsborough, Janine, Mudri, Sherri, Chadwick, Eric, Harder, Brandon, Dillon, Stacey R

“…IL-31 signals through the heterodimeric receptor IL-31RA and oncostatin M receptor (OSMR), and has been linked with the development of atopic dermatitis, a Th2…”
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Novel Immunomodulatory Proteins Generated via Directed Evolution of Variant IgSF Domains by Levin, Steven D, Evans, Lawrence S, Bort, Susan, Rickel, Erika, Lewis, Katherine E, Wu, Rebecca P, Hoover, Joseph, MacNeil, Sean, La, David, Wolfson, Martin F, Rixon, Mark W, Dillon, Stacey R, Kornacker, Michael G, Swanson, Ryan, Peng, Stanford L

“…Immunoglobulin superfamily member (IgSF) proteins play a significant role in regulating immune responses with surface expression on all immune cell subsets,…”
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The C104R mutant impairs the function of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) through haploinsufficiency by Lee, John J., MD, Jabara, Haifa H., BS, Garibyan, Lilit, MD, PhD, Rauter, Ingrid, PhD, Sannikova, Tatyana, BS, Dillon, Stacey R., PhD, Bram, Richard, MD, PhD, Geha, Raif S., MD

“…Background TNFRSF13B , which encodes transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI), is mutated in 10% of patients with…”
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TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease by Gross, Jane A, Johnston, Janet, Mudri, Sherri, Enselman, Rachel, Dillon, Stacey R, Madden, Karen, Xu, Wenfeng, Parrish-Novak, Julia, Foster, Don, Lofton-Day, Cathy, Moore, Margaret, Littau, Alisa, Grossman, Angelika, Haugen, Harald, Foley, Kevin, Blumberg, Hal, Harrison, Kim, Kindsvogel, Wayne, Clegg, Christopher H

“…B cells are important in the development of autoimmune disorders by mechanisms involving disregulated polyclonal B-cell activation, production of pathogenic…”
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Correction: IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function by Singh, Brijendra, Jegga, Anil G, Shanmukhappa, Kumar S, Edukulla, Ramakrishna, Khurana Hershey, Gurjit Kaur, Medvedovic, Mario, Dillon, Stacey R, Madala, Satish K

“…[This corrects the article DOI: 10.1371/journal.pone.0161877.]…”
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Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function by Foster, Don, Parrish-Novak, Julia, Dillon, Stacey R, Nelson, Andrew, Hammond, Angie, Sprecher, Cindy, Gross, Jane A, Johnston, Janet, Madden, Karen, Xu, Wenfeng, West, Jim, Schrader, Sara, Burkhead, Steve, Heipel, Mark, Brandt, Cameron, Kuijper, Joseph L, Kramer, Janet, Conklin, Darrell, Presnell, Scott R, Berry, Jon, Shiota, Faith, Bort, Susan, Hambly, Kevin, Mudri, Sherri, Clegg, Chris, Moore, Margaret, Grant, Francis J, Lofton-Day, Catherine, Gilbert, Teresa, Raymond, Fenella, Ching, Andrew, Yao, Lena, Smith, Deb, Webster, Philippa, Whitmore, Theodore, Maurer, Mark, Kaushansky, Kenneth, Holly, Rick D

“…Cytokines are important in the regulation of haematopoiesis and immune responses, and can influence lymphocyte development. Here we have identified a class I…”
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Toll-like receptor 9, transmembrane activator and calcium-modulating cyclophilin ligand interactor, and CD40 synergize in causing B-cell activation by Ozcan, Esra, MD, Rauter, Ingrid, PhD, Garibyan, Lilit, MD, PhD, Dillon, Stacey R., PhD, Geha, Raif S., MD

“…Background B cells receive activating signals from T cells through CD40, from microbial DNA through Toll-like receptor (TLR) 9, and from dendritic cells…”
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Functional analysis of transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) mutations associated with common variable immunodeficiency by Fried, Ari J., MD, Rauter, Ingrid, PhD, Dillon, Stacey R., PhD, Jabara, Haifa H., BS, Geha, Raif S., MD

“…Signaling by the intracellular domain mutants (K188M and V246F) was intact. Because TACI assembles as a trimer or higher-order oligomer,6 TACI mutants with…”
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A proliferation-inducing ligand mediates follicular lymphoma B-cell proliferation and cyclin D1 expression through phosphatidylinositol 3-kinase–regulated mammalian target of rapamycin activation by Gupta, Mamta, Dillon, Stacey R., Ziesmer, Steven C., Feldman, Andrew L., Witzig, Thomas E., Ansell, Stephen M., Cerhan, James R., Novak, Anne J.

“…A proliferation-inducing ligand (APRIL), as well as its receptors transmembrane activator and calcium-modulating cyclophilin ligand (CAML) interactor (TACI)…”
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Increased BCMA expression in lupus marks activated B cells, and BCMA receptor engagement enhances the response to TLR9 stimulation by Kim, Jinoh, Gross, Jane A., Dillon, Stacey R., Min, Jun-Ki, Elkon, Keith B.

“…B lymphocyte stimulator (BLyS) and APRoliferation inducing ligand (APRIL) are members of the TNF superfamily that regulate B-cell survival and autoreactivity…”
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