Search Results - "Dillon, P."

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation by Wang, Ruoning, Dillon, Christopher P., Shi, Lewis Zhichang, Milasta, Sandra, Carter, Robert, Finkelstein, David, McCormick, Laura L., Fitzgerald, Patrick, Chi, Hongbo, Munger, Joshua, Green, Douglas R.

“…To fulfill the bioenergetic and biosynthetic demand of proliferation, T cells reprogram their metabolic pathways from fatty acid β-oxidation and pyruvate…”
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Programmed necrosis in inflammation: Toward identification of the effector molecules by Wallach, David, Kang, Tae-Bong, Dillon, Christopher P., Green, Douglas R.

“…Until recently, programmed cell death was conceived of as a single set of molecular pathways. We now know of several distinct sets of death-inducing mechanisms…”
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A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria by Llambi, Fabien, Moldoveanu, Tudor, Tait, Stephen W.G., Bouchier-Hayes, Lisa, Temirov, Jamshid, McCormick, Laura L., Dillon, Christopher P., Green, Douglas R.

“…During apoptosis, the BCL-2 protein family controls mitochondrial outer membrane permeabilization (MOMP), but the dynamics of this regulation remain…”
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Mapping the catalytic conformations of an assembly-line polyketide synthase module by Cogan, Dillon P, Zhang, Kaiming, Li, Xiuyuan, Li, Shanshan, Pintilie, Grigore D, Roh, Soung-Hun, Craik, Charles S, Chiu, Wah, Khosla, Chaitan

“…Assembly-line polyketide synthases, such as the 6-deoxyerythronolide B synthase (DEBS), are large enzyme factories prized for their ability to produce specific…”
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Emerging roles for Mitochondrial Rho GTPases in tumor biology by Boulton, Dillon P., Caino, M. Cecilia

“…Mitochondrial Rho GTPases (MIRO1 and MIRO2) are primarily studied for their role as resident mitochondrial anchor proteins that facilitate mitochondria…”
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Sixty years of global progress in managed aquifer recharge by Dillon, P., Stuyfzand, P., Grischek, T., Lluria, M., Pyne, R. D. G., Jain, R. C., Bear, J., Schwarz, J., Wang, W., Fernandez, E., Stefan, C., Pettenati, M., van der Gun, J., Sprenger, C., Massmann, G., Scanlon, B. R., Xanke, J., Jokela, P., Zheng, Y., Rossetto, R., Shamrukh, M., Pavelic, P., Murray, E., Ross, A., Bonilla Valverde, J. P., Palma Nava, A., Ansems, N., Posavec, K., Ha, K., Martin, R., Sapiano, M.

“…The last 60 years has seen unprecedented groundwater extraction and overdraft as well as development of new technologies for water treatment that together…”
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Nationalism and National Identity in North America by Byrd, Dillon P.

“…The study of nationalism in North America has focused heavily on national identity. Much of the scholarship in the region indicates that most individuals…”
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The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis by Alvarez-Diaz, Silvia, Dillon, Christopher P., Lalaoui, Najoua, Tanzer, Maria C., Rodriguez, Diego A., Lin, Ann, Lebois, Marion, Hakem, Razq, Josefsson, Emma C., O’Reilly, Lorraine A., Silke, John, Alexander, Warren S., Green, Douglas R., Strasser, Andreas

“…The kinases RIPK1 and RIPK3 and the pseudo-kinase MLKL have been identified as key regulators of the necroptotic cell death pathway, although a role for MLKL…”
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RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3 by Dillon, Christopher P., Weinlich, Ricardo, Rodriguez, Diego A., Cripps, James G., Quarato, Giovanni, Gurung, Prajwal, Verbist, Katherine C., Brewer, Taylor L., Llambi, Fabien, Gong, Yi-Nan, Janke, Laura J., Kelliher, Michelle A., Kanneganti, Thirumala-Devi, Green, Douglas R.

“…Receptor-interacting protein kinase (RIPK)-1 is involved in RIPK3-dependent and -independent signaling pathways leading to cell death and/or inflammation…”
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RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus by Nogusa, Shoko, Thapa, Roshan J., Dillon, Christopher P., Liedmann, Swantje, Oguin, Thomas H., Ingram, Justin P., Rodriguez, Diego A., Kosoff, Rachelle, Sharma, Shalini, Sturm, Oliver, Verbist, Katherine, Gough, Peter J., Bertin, John, Hartmann, Boris M., Sealfon, Stuart C., Kaiser, William J., Mocarski, Edward S., López, Carolina B., Thomas, Paul G., Oberst, Andrew, Green, Douglas R., Balachandran, Siddharth

“…Influenza A virus (IAV) is a lytic virus in primary cultures of many cell types and in vivo. We report that the kinase RIPK3 is essential for IAV-induced lysis…”
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Mitochondrial Fission and Fusion in Tumor Progression to Metastasis by Boulton, Dillon P, Caino, M Cecilia

“…Mitochondria are highly dynamic organelles which can change their shape, via processes termed fission and fusion, in order to adapt to different environmental…”
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Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis by Oberst, Andrew, Dillon, Christopher P., Weinlich, Ricardo, McCormick, Laura L., Fitzgerald, Patrick, Pop, Cristina, Hakem, Razq, Salvesen, Guy S., Green, Douglas R.

“…Caspase-8 joins RIPK at the death Caspase-8 mediates apoptosis induced by 'death receptors' on the cell's surface. At the same time, it is able to prevent…”
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Structure and Mechanisms of Assembly-Line Polyketide Synthases by Soohoo, Alexander M, Cogan, Dillon P, Brodsky, Krystal L, Khosla, Chaitan

“…Three decades of studies on the multifunctional 6-deoxyerythronolide B synthase have laid a foundation for understanding the chemistry and evolution of…”
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FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes by Gurung, Prajwal, Anand, Paras K, Malireddi, R K Subbarao, Vande Walle, Lieselotte, Van Opdenbosch, Nina, Dillon, Christopher P, Weinlich, Ricardo, Green, Douglas R, Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi

“…The Nlrp3 inflammasome is critical for host immunity, but the mechanisms controlling its activation are enigmatic. In this study, we show that loss of FADD or…”
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Characterization of glutamyl-tRNA–dependent dehydratases using nonreactive substrate mimics by Bothwell, Ian R., Cogan, Dillon P., Kim, Terry, Reinhardt, Christopher J., van der Donk, Wilfred A., Nair, Satish K.

“…The peptide natural product nisin has been used as a food preservative for 6 decades with minimal development of resistance. Nisin contains the unusual amino…”
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Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells by Martinez, Jennifer, Almendinger, Johann, Oberst, Andrew, Ness, Rachel, Dillon, Christopher P, Fitzgerald, Patrick, Hengartner, Michael O, Green, Douglas R

“…The recognition and clearance of dead cells is a process that must occur efficiently to prevent an autoimmune or inflammatory response. Recently, a process was…”
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Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis by Rodriguez, D A, Weinlich, R, Brown, S, Guy, C, Fitzgerald, P, Dillon, C P, Oberst, A, Quarato, G, Low, J, Cripps, J G, Chen, T, Green, D R

“…Mixed lineage kinase domain-like pseudokinase (MLKL) mediates necroptosis by translocating to the plasma membrane and inducing its rupture. The activation of…”
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The association between somatic cell count and selective dry cow therapy, milking routine, and dry cow management practices in early-lactation cows from 21 commercial grazing dairy herds by Clabby, C., Valldecabres, A., Dillon, P., O'Sullivan, K., Arkins, S., Flynn, J., McCarthy, S., Silva Boloña, P.

“…The list of standard abbreviations for JDS is available at adsa.org/jds-abbreviations-24. Nonstandard abbreviations are available in the Notes. This…”
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Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score by Desikan, Rahul S, Fan, Chun Chieh, Wang, Yunpeng, Schork, Andrew J, Cabral, Howard J, Cupples, L Adrienne, Thompson, Wesley K, Besser, Lilah, Kukull, Walter A, Holland, Dominic, Chen, Chi-Hua, Brewer, James B, Karow, David S, Kauppi, Karolina, Witoelar, Aree, Karch, Celeste M, Bonham, Luke W, Yokoyama, Jennifer S, Rosen, Howard J, Miller, Bruce L, Dillon, William P, Wilson, David M, Hess, Christopher P, Pericak-Vance, Margaret, Haines, Jonathan L, Farrer, Lindsay A, Mayeux, Richard, Hardy, John, Goate, Alison M, Hyman, Bradley T, Schellenberg, Gerard D, McEvoy, Linda K, Andreassen, Ole A, Dale, Anders M

“…Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost importance. Although genetic studies have identified AD-associated SNPs in…”
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RIPK-Dependent Necrosis and Its Regulation by Caspases: A Mystery in Five Acts by Green, Douglas R., Oberst, Andrew, Dillon, Christopher P., Weinlich, Ricardo, Salvesen, Guy S.

“…Caspase-8, FADD, and FLIP orchestrate apoptosis in response to death receptor ligation. Mysteriously however, these proteins are also required for normal…”
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