Search Results - "Dillon, Laura A"

Towards a consensus definition of immune exclusion in cancer by Tiwari, Ankur, Oravecz, Tamas, Dillon, Laura A, Italiano, Antoine, Audoly, Laurent, Fridman, Wolf Hervé, Clifton, Guy Travis

“…The immune cell topography of solid tumors has been increasingly recognized as an important predictive factor for progression of disease and response to…”
Get full text

Unlocking the secrets of the genome by Henikoff, Steven, MacAlpine, David M, Stein, Lincoln, Snyder, Michael, Lieb, Jason D, Celniker, Susan E, Dillon, Laura A. L, White, Kevin P, Waterston, Robert H, Micklem, Gos, Lai, Eric C, Karpen, Gary H, Gerstein, Mark B, Gunsalus, Kristin C, Piano, Fabio, Kellis, Manolis

“…Despite the successes of genomics, little is known about how genetic information produces complex organisms. A look at the crucial functional elements of fly…”
Get full text

Simultaneous transcriptional profiling of Leishmania major and its murine macrophage host cell reveals insights into host-pathogen interactions by Dillon, Laura A L, Suresh, Rahul, Okrah, Kwame, Corrada Bravo, Hector, Mosser, David M, El-Sayed, Najib M

“…Parasites of the genus Leishmania are the causative agents of leishmaniasis, a group of diseases that range in manifestations from skin lesions to fatal…”
Get full text

Transcriptomic profiling of gene expression and RNA processing during Leishmania major differentiation by Dillon, Laura A L, Okrah, Kwame, Hughitt, V Keith, Suresh, Rahul, Li, Yuan, Fernandes, Maria Cecilia, Belew, A Trey, Corrada Bravo, Hector, Mosser, David M, El-Sayed, Najib M

“…Protozoan parasites of the genus Leishmania are the etiological agents of leishmaniasis, a group of diseases with a worldwide incidence of 0.9-1.6 million…”
Get full text

Meta-transcriptome Profiling of the Human-Leishmania braziliensis Cutaneous Lesion by Christensen, Stephen M, Dillon, Laura A L, Carvalho, Lucas P, Passos, Sara, Novais, Fernanda O, Hughitt, V Keith, Beiting, Daniel P, Carvalho, Edgar M, Scott, Phillip, El-Sayed, Najib M, Mosser, David M

“…Host and parasite gene expression in skin biopsies from Leishmania braziliensis-infected patients were simultaneously analyzed using high throughput…”
Get full text

The generation of macrophages with anti‐inflammatory activity in the absence of STAT6 signaling by Fleming, Bryan D., Chandrasekaran, Prabha, Dillon, Laura A. L., Dalby, Elizabeth, Suresh, Rahul, Sarkar, Arup, El‐Sayed, Najib M., Mosser, David M.

“…Identification of transcriptional signatures of anti‐inflammatory macrophages and their role in lethal endotoxemia. Macrophages readily change their phenotype…”
Get full text

Early Leukocyte Responses in Ex-Vivo Models of Healing and Non-Healing Human Leishmania (Viannia) panamensis Infections by Gomez, Maria Adelaida, Belew, Ashton Trey, Navas, Adriana, Rosales-Chilama, Mariana, Murillo, Julieth, Dillon, Laura A L, Alexander, Theresa A, Martinez-Valencia, Alvaro, El-Sayed, Najib M

“…Early host-pathogen interactions drive the host response and shape the outcome of natural infections caused by intracellular microorganisms. These interactions…”
Get full text

Correction: Meta-transcriptome Profiling of the Human-Leishmania braziliensis Cutaneous Lesion by Christensen, Stephen M, Dillon, Laura A L, Carvalho, Lucas P, Passos, Sara, Novais, Fernanda O, Hughitt, V Keith, Beiting, Daniel P, Carvalho, Edgar M, Scott, Phillip, El-Sayed, Najib M, Mosser, David M

“…[This corrects the article DOI: 10.1371/journal.pntd.0004992.]…”
Get full text

The Transcriptome of Leishmania major Developmental Stages in Their Natural Sand Fly Vector by Inbar, Ehud, Hughitt, V Keith, Dillon, Laura A L, Ghosh, Kashinath, El-Sayed, Najib M, Sacks, David L

“…The life cycle of the parasite in the sand fly vector involves differentiation into several distinctive forms, each thought to represent an adaptation to…”
Get full text

Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures by Fernandes, Maria Cecilia, Dillon, Laura A L, Belew, Ashton Trey, Bravo, Hector Corrada, Mosser, David M, El-Sayed, Najib M

“…Macrophages are mononuclear phagocytes that constitute a first line of defense against pathogens. While lethal to many microbes, they are the primary host…”
Get full text

1497 The epithelium-stroma interface serves as a barrier to immune cell infiltration across tumor immune phenotypes in epithelial cancers by Sher, Xinwei, Gootkind, Fredrick D, Italiano, Antoine, Peyraud, Florent, Guégan, Jean-Philippe, Clifton, Guy T, Dillon, Laura A

“…BackgroundTumor immune phenotypes - immune-infiltrated, immune-desert, and immune-excluded, characterized by the presence and distribution of lymphocytes in…”
Get full text

1486 DDR1 expression is associated with a worse prognosis in intrahepatic cholangiocarcinoma by Mueller, Amy, Dillon, Laura A, Sher, Xinwei, Eder, Joseph P, Schuerpf, Thomas, Kwong, Lawrence N, Clifton, Guy T

“…BackgroundDiscoidin Domain Receptor 1 (DDR1) is a tyrosine kinase expressed on cancer cells that binds to collagen, is associated with T-cell exclusion and…”
Get full text

1509-H Quantitative assessment of the tumor microenvironment using the Aurora™ 3D Spatial Biology Platform by Stoltzfus, Caleb, Alvarsson, Alexandra, DeWitt, Anna, Wilson, Jasmine, Grant, Nathan, Simmons, David, Olin, Brandy, Phillips, Bonnie, Dillon, Laura A, Clifton, Guy Travis, Reder, Nicholas

“…BackgroundAnalysis of the three-dimensional (3D) landscape of the tumor microenvironment (TME) has the potential to transform diagnosis and drug development…”
Get full text

Correlation of immune phenotypes derived from H&E-stained whole slide images with prognosis and response to checkpoint inhibitors in NSCLC by Le, Nhat, Dillon, Laura A., Shen, Ciyue, Bronnimann, Matthew, Zhang, Jun, Hipp, Jennifer, Nguyen, Tan, Griffin, Michael, Nercessian, Michael, Brosnan-Cashman, Jacqueline, Egger, Robert, Guégan, Jean Philippe, Bessede, Alban, Peyraud, Florent, Italiano, Antoine, Sher, Xinwei, Clifton, G. Travis, Rahsepar, Bahar

“…8539 Background: The classification of tumors as inflamed, excluded or desert based on spatial patterns of tumor infiltrating lymphocytes (TILs) is a potential…”
Get full text

1287 Comparison of multiplex immunofluorescence and H&E-based approaches for characterization of the tumor microenvironment by Gootkind, Fredrick D, Sher, Xinwei, Steele, Keith, Peyraud, Florent, Guégan, Jean-Philippe, Italiano, Antoine, Clifton, Guy T, Dillon, Laura A

“…BackgroundPredictive models applied to digital pathology images show promise for the rapid and objective analysis of patient samples to identify features of…”
Get full text

1287 Comparison of multiplex immunofluorescence and H E-based approaches for characterization of the tumor microenvironment by Antoine Italiano, Xinwei Sher, Keith Steele, Guy T Clifton, Florent Peyraud, Laura A Dillon, Jean-Philippe Guégan, Fredrick D Gootkind

Get full text

Abstract 2916: Discoidin domain receptor 1 (DDR1) expression is associated with degree of immune exclusion across epithelial tumors by Sher, Xinwei, Gootkind, Fredrick D., Schürpf, Thomas, Peyraud, Florent, Guégan, Jean-Philippe, Italiano, Antoine, Clifton, G. Travis, Dillon, Laura A.

“…Background: Discoidin domain receptor 1 (DDR1) is highly expressed in epithelial cancers and has been implicated in tumor growth, invasion, and lack of…”
Get full text

Abstract 7392: Machine learning-based identification of H&E-derived morphologic features associated with CD8+ T cell immune exclusion by Wang, Yanchao, Gootkind, Fredrick D., Peyraud, Florent, Guégan, Jean-Philippe, Italiano, Antoine, Clifton, G. Travis, Dillon, Laura A., Sher, Xinwei

“…Background: Immune exclusion is characterized by a predominance of CD8+ T cells in the stroma of the tumor microenvironment (TME) which are not in contact with…”
Get full text

Abstract 2309: 3D spatial quantification of lymphocyte infiltration and collagen features in the tumor microenvironment using a novel assay: 3D I/O Pro by Stoltzfus, Caleb, Wilson, Jasmine, Grant, Nathan, Alvarsson, Alexandra, DeWitt, Anna, Simmons, David, Olin, Brandy, Phillips, Bonnie, Dillon, Laura A., Clifton, G. Travis, Reder, Nicholas P.

“…Background: The composition of the tumor microenvironment (TME) is a major determinant of response to therapy in many solid tumors. To-date, characterization…”
Get full text

Abstract 2108: High prevalence of immune exclusion in cancer as determined by pathologist assessment and image analysis by Peyraud, Florent, Gootkind, Fredrick D., Italiano, Antoine, Bessede, Alban, Guegan, Jean-Philippe, Sher, Xinwei, Schürpf, Thomas, Clifton, Guy T., Dillon, Laura A.

“…Background: Immune infiltrated tumors have high levels of lymphocytes contacting tumor cells and are more responsive to checkpoint inhibitors. Tumors with few…”
Get full text