Search Results - "Dillmann, W H"

Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetes by Makino, A, Scott, B. T, Dillmann, W. H

“…Aims/hypothesis Mitochondria frequently change their shapes by fusion and fission and these morphological dynamics play important roles in mitochondrial…”
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Cellular action of thyroid hormone on the heart by Dillmann, W H

“…Changes in thyroid status markedly influence cardiac contractile and electrical activity. The predominant route by which triiodothyronine (T3) affects cardiac…”
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Heat shock protein 70 kDa over-expression and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigrostriatal degeneration in mice by Gao, L, Díaz-Martín, J, Dillmann, W.H, López-Barneo, J

“…Abstract Oxidative damage in the dopaminergic neurons of substantia nigra pars compacta (SNpc) plays an important role in the pathogenesis of Parkinson's…”
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Identification of functional angiotensin II receptors on rat cardiac fibroblasts by VILLARREAL, F. J, KIM, N. N, UNGAB, G. D, PRINTZ, M. P, DILLMANN, W. H

“…Cardiac hypertrophy results in an increased deposition of the extracellular matrix (ECM) proteins fibronectin and collagen. Recent evidence indicates that…”
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Small heat shock proteins and protection against ischemic injury in cardiac myocytes by MARTIN, J. L, MESTRIL, R, HILAL-DANDAN, R, BRUNTON, L. L, DILLMANN, W. H

“…Overexpression of the inducible hsp70 protects against ischemic cardiac damage. However, it is unclear whether the small heat shock proteins hsp27 and…”
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Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury by Marber, M S, Mestril, R, Chi, S H, Sayen, M R, Yellon, D M, Dillmann, W H

“…Myocardial protection and changes in gene expression follow whole body heat stress. Circumstantial evidence suggests that an inducible 70-kD heat shock protein…”
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Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation by He, H, Giordano, F J, Hilal-Dandan, R, Choi, D J, Rockman, H A, McDonough, P M, Bluhm, W F, Meyer, M, Sayen, M R, Swanson, E, Dillmann, W H

“…The Ca2+ ATPase of the sarcoplasmic reticulum (SERCA2) plays a dominant role in lowering cytoplasmic calcium levels during cardiac relaxation and reduction of…”
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Trophic effects of angiotensin II on neonatal rat cardiac myocytes are mediated by cardiac fibroblasts by Kim, N N, Villarreal, F J, Printz, M P, Lee, A A, Dillmann, W H

“…Cultured neonatal rat cardiac fibroblasts (NF) and myocytes (NM) were used to examine the distribution of angiotensin II (ANG II) receptors and the potential…”
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Induction of HSP70 in cultured rat neonatal cardiomyocytes by hypoxia and metabolic stress by IWAKI, K, SHUN-HUA CHI, DILLMANN, W. H, MESTRIL, R

“…A cultured neonatal rat cardiomyocyte model is used to investigate the expression of the inducible heat shock protein 70 (HSP70i) during hypoxia/reoxygenation…”
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Overexpression of heat shock protein 72 in transgenic mice decreases infarct size in vivo by HUTTER, J. J, MESTRIL, R, TAM, E. K. W, SIEVERS, R. E, DILLMANN, W. H, WOLFE, C. L

“…Previous studies have demonstrated that induction of heat shock protein (HSP) 72 by whole-body hyperthermia reduces infarct size in an in vivo model of…”
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Expression of inducible stress protein 70 in rat heart myogenic cells confers protection against simulated ischemia-induced injury by Mestril, R, Chi, S H, Sayen, M R, O'Reilly, K, Dillmann, W H

“…Myocardial ischemia markedly increases the expression of several members of the stress/heat shock protein (HSP) family, especially the inducible HSP70…”
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Calcium regulatory proteins and their alteration by transgenic approaches by Dillmann, W.H

“…Abnormalities in calcium flux have been linked to abnormal contractile behavior of the heart in patients with congestive heart failure as well as in animal…”
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Protection against myocardial dysfunction after a brief ischemic period in transgenic mice expressing inducible heat shock protein 70 by Trost, S U, Omens, J H, Karlon, W J, Meyer, M, Mestril, R, Covell, J W, Dillmann, W H

“…Brief ischemic periods lead to myocardial dysfunction without myocardial infarction. It has been shown that expression of inducible HSP70 in hearts of…”
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Isolation of a novel inducible rat heat-shock protein (HSP70) gene and its expression during ischaemia/hypoxia and heat shock by Mestril, R, Chi, S H, Sayen, M R, Dillmann, W H

“…Most of the members of the mammalian heat-shock protein (HSP) gene family have been studied and isolated from human and mouse cells. Few studies have…”
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Adenovirus-mediated gene transfer reconstitutes depressed sarcoplasmic reticulum Ca2+-ATPase levels and shortens prolonged cardiac myocyte Ca2+ transients by GIORDANO, F. J, HE, H, MCDONOUGH, P, MEYER, M, SAYEN, M. R, DILLMANN, W. H

“…Decreased expression of the sarcoplasmic reticulum (SR) Ca2+-ATPase of the cardiac myocyte (SERCA2) and abnormal Ca2+ regulation have been independently linked…”
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Diabetes and the Accompanying Hyperglycemia Impairs Cardiomyocyte Calcium Cycling through Increased Nuclear O-GlcNAcylation by Clark, Raymond J., McDonough, Patrick M., Swanson, Eric, Trost, Susanne U., Suzuki, Misa, Fukuda, Minoru, Dillmann, Wolfgang H.

“…Diabetic cardiomyopathy is characterized by impaired cardiac contractility leading to poor myocardial performance. We investigated the role that the hexosamine…”
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Diabetes and Thyroid-Hormone-Induced Changes in Cardiac Function and Their Molecular Basis by Dillmann, W H

“…The heart is a major target organ for insulin and thyroid hormone action, and marked changes in cardiac function occur in patients with hyper- or…”
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Influence of thyroid hormone and retinoic acid on slow sarcoplasmic reticulum Ca2+ ATPase and myosin heavy chain alpha gene expression in cardiac myocytes. Delineation of cis-active DNA elements that confer responsiveness to thyroid hormone but not to retinoic acid by Rohrer, D K, Hartong, R, Dillmann, W H

“…The mRNA encoding the sarcoplasmic reticulum (SR) Ca2+ ATPase is highly influenced by thyroid hormone (T3) in the hearts of intact animals. We show here that…”
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Ischemia Induces Changes in the Level of mRNAs Coding for Stress Protein 71 and Creatine Kinase M by Mehta, Harshvardhan B, Popovich, Brett K, Dillmann, Wolfgang H

“…Hyperthermia, hypoxia, and other conditions induce the appearance of heat shock or stress proteins in cells. We have previously shown that in the ischemic dog…”
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Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice by CUMMINGS, Christopher J, YALING SUN, OPAL, Puneet, ANTALFFY, Barbara, MESTRIL, Ruben, ORR, Harry T, DILLMANN, Wolfgang H, ZOGHBI, Huda Y

“…Many neurodegenerative diseases are caused by gain-of-function mechanisms in which the disease-causing protein is altered, becomes toxic to the cell, and…”
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