The effects of vagal nerve stimulation in focal cerebral ischemia and reperfusion model

The effects of vagal nerve stimulation in focal cerebral ischemia and reperfusion model

This study aimed to investigate the effects of VNS in transient middle cerebral artery occlusion and reperfusion (MCAO/R) rat model of ischemia based on behavioral, morphological, and molecular approaches. Wistar albino rats were divided into 3 groups: ischemia-reperfusion (I/R), I/R+VNS, and sham (...

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Published in:Turkish neurosurgery Vol. 23; no. 4; pp. 451 - 457
Main Authors: Ekici, Fatih, Karson, Ayse, Dillioglugil, Meltem Ozden, Gurol, Gonul, Kir, Hale Maral, Ates, Nurbay
Format: Journal Article
Language:English
Published: Turkey 2013
Subjects:
Animals
Behavior, Animal - physiology
Brain Ischemia - therapy
Cerebral Infarction - physiopathology
Cerebral Infarction - therapy
Coloring Agents
Electrodes, Implanted
Glutathione - metabolism
Infarction, Middle Cerebral Artery - therapy
Male
Malondialdehyde - metabolism
Oxidative Stress - physiology
Rats
Rats, Wistar
Reperfusion Injury - therapy
Superoxide Dismutase - metabolism
Tetrazolium Salts
Vagus Nerve Stimulation
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Summary:This study aimed to investigate the effects of VNS in transient middle cerebral artery occlusion and reperfusion (MCAO/R) rat model of ischemia based on behavioral, morphological, and molecular approaches. Wistar albino rats were divided into 3 groups: ischemia-reperfusion (I/R), I/R+VNS, and sham (for I/R). Each group was further divided into two subgroups for the assessment of neurological deficits and infarct area, or biochemical parameters related to oxidative stress. The infarct area and neurological scores were significantly lower in I/R+VNS group compared with the I/R group. MDA levels were significantly higher in I/R group compared to control and I/R+VNS groups in the cortical and subcortical specimens. There were also betweengroup differences in terms of GSH levels. GSH levels were higher in sham group compared with and I/R and I/R+VNS groups in cortical specimens whereas these levels for lower in I/R group compared to control and I/R+VNS groups in the subcortical specimens. SOD activity was higher in control group compared to I/R and I/R+VNS groups both in the cortical and subcortical specimens. There was no difference between I/R and I/R+VNS groups in neither cortical nor subcortical specimens. The neuroprotective and antioxidant properties of VNS suggest its efficacy as a potential anti-ischemic treatment.
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ISSN:1019-5149
DOI:10.5137/1019-5149.JTN.7114-12.1