Search Results - "Dikshit, Madhu"

Metabolic Insight of Neutrophils in Health and Disease by Kumar, Sachin, Dikshit, Madhu

“…Neutrophils are the most abundant, short lived, and terminally differentiated leukocytes with distinct tiers of arsenals to counter pathogens. Neutrophils were…”
Get full text

Glycolysis dependent lactate formation in neutrophils: A metabolic link between NOX-dependent and independent NETosis by Awasthi, Deepika, Nagarkoti, Sheela, Sadaf, Samreen, Chandra, Tulika, Kumar, Sachin, Dikshit, Madhu

“…Neutrophil extracellular traps (NETs) play a pivotal role in the innate immune defense, as well as in the pathophysiology of various inflammatory disease…”
Get full text

Reactive oxygen species-induced activation of ERK and p38 MAPK mediates PMA-induced NETs release from human neutrophils by Keshari, Ravi S., Verma, Anupam, Barthwal, Manoj K., Dikshit, Madhu

“…Neutrophils/polymorphonuclear leukocytes (PMNs), an important component of innate immune system, release extracellular traps (NETs) to eliminate invaded…”
Get full text

Role of pyruvate kinase M2 in oxidized LDL-induced macrophage foam cell formation and inflammation[S] by Kumar, Amit, Gupta, Priya, Rana, Minakshi, Chandra, Tulika, Dikshit, Madhu, Barthwal, Manoj Kumar

“…Pyruvate kinase M2 (PKM2) links metabolic and inflammatory dysfunction in atherosclerotic coronary artery disease; however, its role in oxidized LDL…”
Get full text

Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation by Awasthi, Deepika, Nagarkoti, Sheela, Kumar, Amit, Dubey, Megha, Singh, Abhishek Kumar, Pathak, Priya, Chandra, Tulika, Barthwal, Manoj Kumar, Dikshit, Madhu

“…Neutrophil extracellular traps (NETs) formation was initially linked with host defence and extracellular killing of pathogens. However, recent studies have…”
Get full text

Cytokines induced neutrophil extracellular traps formation: implication for the inflammatory disease condition by Keshari, Ravi S, Jyoti, Anupam, Dubey, Megha, Kothari, Nikhil, Kohli, Monica, Bogra, Jaishri, Barthwal, Manoj K, Dikshit, Madhu

“…Neutrophils (PMNs) and cytokines have a critical role to play in host defense and systemic inflammatory response syndrome (SIRS). Neutrophil extracellular…”
Get full text

Standardized fraction of Xylocarpus moluccensis inhibits inflammation by modulating MAPK-NFκB and ROS-HIF1α-PKM2 activation by Agarwal, Heena, Sukka, Santosh Reddy, Singh, Vishal, Dikshit, Madhu, Barthwal, Manoj Kumar

“…Objective Present study investigates the effect of Xylocarpus moluccensis (Lamk.) M. Roem fruit fraction (CDR) on endotoxemia and explores the underlying…”
Get full text

Bacterial Siderophores Hijack Neutrophil Functions by Saha, Piu, Yeoh, Beng San, Olvera, Rodrigo A, Xiao, Xia, Singh, Vishal, Awasthi, Deepika, Subramanian, Bhagawat C, Chen, Qiuyan, Dikshit, Madhu, Wang, Yanming, Parent, Carole A, Vijay-Kumar, Matam

“…Neutrophils are the primary immune cells that respond to inflammation and combat microbial transgression. To thrive, the bacteria residing in their mammalian…”
Get full text

Modulation of Insulin Resistance, Dyslipidemia and Serum Metabolome in iNOS Knockout Mice following Treatment with Nitrite, Metformin, Pioglitazone, and a Combination of Ampicillin and Neomycin by Aggarwal, Hobby, Pathak, Priya, Kumar, Yashwant, Jagavelu, Kumaravelu, Dikshit, Madhu

“…Oxidative and nitrosative stress plays a pivotal role in the incidence of metabolic disorders. Studies from this lab and others in iNOS mice have demonstrated…”
Get full text

Pharmacological potential of Withania somnifera (L.) Dunal and Tinospora cordifolia (Willd.) Miers on the experimental models of COVID-19, T cell differentiation, and neutrophil functions by Rizvi, Zaigham Abbas, Babele, Prabhakar, Madan, Upasna, Sadhu, Srikanth, Tripathy, Manas Ranjan, Goswami, Sandeep, Mani, Shailendra, Dikshit, Madhu, Awasthi, Amit

“…Cytokine release syndrome (CRS) due to severe acute respiratory coronavirus-2 (SARS-CoV-2) infection leads to life-threatening pneumonia which has been…”
Get full text

In vitro effect of Withania somnifera, AYUSH-64, and remdesivir on the activity of CYP-450 enzymes: Implications for possible herb−drug interactions in the management of COVID-19 by Kasarla, Siva Swapna, Borse, Swapnil P., Kumar, Yashwant, Sharma, Neha, Dikshit, Madhu

“…Ayurvedic medicines Withania somnifera Dunal ( ashwagandha ) and AYUSH-64 have been used for the prevention and management of COVID-19 in India. The present…”
Get full text

The aqueous root extract of Withania somnifera ameliorates LPS-induced inflammatory changes in the in vitro cell-based and mice models of inflammation by Sharma, Phulwanti Kumari, Kumar, Lokesh, Goswami, Yamini, Pujani, Mukta, Dikshit, Madhu, Tandon, Ruchi

“…Most critically ill COVID-19 patients have bronchitis, pneumonia, and acute respiratory distress syndrome (ARDS) due to excessive inflammatory conditions…”
Get full text

Crystallographic mining of ASK1 regulators to unravel the intricate PPI interfaces for the discovery of small molecule by Agrahari, Ashish Kumar, Dikshit, Madhu, Asthana, Shailendra

“…[Display omitted] Protein seldom performs biological activities in isolation. Understanding the protein–protein interactions’ physical rewiring in response to…”
Get full text

Nitric oxide-mediated apoptosis of neutrophils through caspase-8 and caspase-3-dependent mechanism by Dubey, Megha, Nagarkoti, Sheela, Awasthi, Deepika, Singh, Abhishek K, Chandra, Tulika, Kumaravelu, J, Barthwal, Manoj K, Dikshit, Madhu

“…Neutrophils play an indispensable role in killing of invading pathogens by enhancing reactive oxygen species (ROS) and NO generation, and subsequently…”
Get full text

Saroglitazar and Hepano treatment offers protection against high fat high fructose diet induced obesity, insulin resistance and steatosis by modulating various class of hepatic and circulating lipids by Sarkar, Soumalya, Kumari, Deepika, Gupta, Sonu Kumar, Sharma, Vipin, Mukhi, Sumedha, Kamboj, Parul, Sasibhushan, Vedula, Rai, Rajiva Kumar, Jatavallabhula, Sastry Lakshminarayana, Mahajan, Dinesh, Kumar, Yashwant, Kumar, Ajay, Dikshit, Madhu

“…Higher global prevalence of non-alcoholic fatty liver disease (NAFLD) is associated with obesity, steatosis, and insulin resistance (IR), and often progresses…”
Get full text

Oxidative and Nitrosative Stress in Major Depressive Disorder: A Case Control Study by Somani, Aditya, Singh, Abhishek Kumar, Gupta, Bandna, Nagarkoti, Sheela, Dalal, Pronob Kumar, Dikshit, Madhu

“…The role of increased oxidative stress and alterations to the nitric oxide (NO) pathway have been implicated in major depressive disorder (MDD). The two…”
Get full text

Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosis by Rizvi, Zaigham Abbas, Babele, Prabhakar, Sadhu, Srikanth, Madan, Upasna, Tripathy, Manas Ranjan, Goswami, Sandeep, Mani, Shailendra, Kumar, Sachin, Awasthi, Amit, Dikshit, Madhu

“…Severe coronavirus disease (COVID-19) is accompanied by acute respiratory distress syndrome and pulmonary pathology, and is presented mostly with an…”
Get full text

Mesenchymal stem cells from fetal heart attenuate myocardial injury after infarction: an in vivo serial pinhole gated SPECT-CT study in rats by Garikipati, Venkata Naga Srikanth, Jadhav, Sachin, Pal, Lily, Prakash, Prem, Dikshit, Madhu, Nityanand, Soniya

“…Mesenchymal stem cells (MSC) have emerged as a potential stem cell type for cardiac regeneration after myocardial infarction (MI). Recently, we isolated and…”
Get full text

Evaluation of Ayush-64 (a Polyherbal Formulation) and Its Ingredients in the Syrian Hamster Model for SARS-CoV-2 Infection Reveals the Preventative Potential of Alstonia scholaris by Rizvi, Zaigham Abbas, Madan, Upasna, Tripathy, Manas Ranjan, Goswami, Sandeep, Mani, Shailendra, Awasthi, Amit, Dikshit, Madhu

“…In the current study, we evaluated the efficacy of Ayush-64 (A64), a polyherbal formulation containing (L.) R. Br. ( ), L. ( ), Royle ex Benth ( ), and (Roxb.)…”
Get full text

Increased myeloperoxidase enzyme activity in plasma is an indicator of inflammation and onset of sepsis by Kothari, Nikhil, MD, Keshari, Ravi S., MSc, Bogra, Jaishri, MD, Kohli, Monica, MD, Abbas, Haider, MD, Malik, Anita, MD, Dikshit, Madhu, PhD, Barthwal, Manoj K., PhD

“…Abstract Introduction Circulating lipopolysaccharides released from bacteria may activate both neutrophils and monocytes. The activated neutrophils release…”
Get full text