Search Results - "Dikshit, Anushka"

UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling by Dikshit, Anushka, Jin, Yingai J, Degan, Simone, Hwang, Jihwan, Foster, Matthew W, Li, Chuan-Yuan, Zhang, Jennifer Y

“…UBE2N is a K63-specific ubiquitin conjugase linked to various immune disorders and cancer. Here, we demonstrate that UBE2N and its partners UBE2V1 and UBE2V2…”
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1490 High-plex co-detection of RNA and protein to explore tumor-immune interactions utilizing RNAscope with imaging mass cytometry by Pemberton, James, Kala, Smriti, Dikshit, Anushka, Hupple, Clinton

“…BackgroundFuture advancements in immuno-oncology will be propelled by the tools capable of deciphering the spatial organization of distinct cell types within…”
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Optimized S-Curve Transformation and Wavelets-Based Fusion for Contrast Elevation of Breast Tomograms and Mammograms by Bhateja, Vikrant, Urooj, Shabana, Dikshit, Anushka, Rai, Ashruti

“…For the purpose of accuracy in detection and diagnosis, Computer-Aided Diagnosis (CAD) is preferred by radiologists for the analysis of Breast Cancer. However,…”
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103 Quantitative evaluation of tumor tissues using a combined fluorescence in situ hybridization and immunofluorescence assay by Lioux, Ghislaine, Carmell, Natasha, Dikshit, Anushka, Collins, Kim, Tomac, Michael, Maston, Levi, Lillard, Kate

“…BackgroundUnderstanding the complex interactions between tumor, immune, and stromal cells in the tumor microenvironment (TME) is essential for understanding…”
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92 Single cell and spatial multiplex profiling of immune cell markers in FFPE tumor tissues using the novel RNAscope™ HiPlex v2 in situ hybridization assay by Basak, Sayantani, Dikshit, Anushka, Yu, Ming, Ji, HaYeun, Chang, Ching-Wei, Zhang, Bingqing

“…BackgroundThe tumor microenvironment (TME) is highly complex, comprised of tumor cells, immune cells, stromal cells, and extracellular matrix. Understanding…”
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71 Integration of RNA in situ hybridization and sequential immunofluorescence for same-slide fully automated multi-omics analysis of the tumor microenvironment by Comberlato, Alice, Manoukian, Arec, Juricic, Paula, Bordignon, Pino, Kehren, Alexandre, Faillétaz, Alix, Dikshit, Anushka, Doolittle, Emerald, Delvillar, Rose, Zhou, Steve, Chang, Ching-Wei, Wang, Li-Chong

“…BackgroundSpatial biology has transformed our understanding of the tumor microenvironment (TME) by enabling the study of tissue composition and intercellular…”
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79 Multiplexed detection of RNA and protein to interrogate the tumor-immune landscape with a novel automated RNAscope™ assay by Deshpande, Sonali, Dikshit, Anushka, Kim, Ge-Ah, Yu, Julia, Chatelain, Laetitia, George, Nancy, Wang, Li-Chong, Srinivasan, Maithreyan

“…BackgroundStudying cell-cell interactions can have important implications in immuno-oncology, inflammation, and neuroscience. Tissue heterogeneity poses…”
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4 Molecularly guided multiplexed digital spatial analysis reveals differential gene expression profiles in the WNT-β-catenin pathway between melanoma and prostate tumors by Dikshit, Anushka, Zollinger, Dan, Nguyen, Karen, McKay-Fleisch, Jill, Fuhrman, Kit, Ma, Xiao-jun

“…BackgroundThe canonical WNT-β-catenin signaling pathway is vital for development and tissue homeostasis but becomes strongly tumorigenic when dysregulated. and…”
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Potential Utility of Synthetic D-Lactate Polymers in Skin Cancer by Dikshit, Anushka, Lu, Junqi, Ford, Amy E., Degan, Simone, Jin, Yingai J., Sun, Huiying, Nichols, Amanda, Salama, April K.S., Beasley, Georgia, Gooden, David, Zhang, Jennifer Y.

“…Increased breakdown of glucose through glycolysis in both aerobic and anaerobic conditions is a hallmark feature of mammalian cancer and leads to increased…”
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86 Co-detection of RNA and protein in FFPE tumor samples by combining RNAscope in situ hybridization and immunohistochemistry assays by Dikshit, Anushka, Ma, Xiao-jun, Doolittle, Emerald, Hernandez, Lydia, Sheldon, Jyoti, Kernag, Siobhan, Pimentel, Helly Xiao Yan, Zong, Hailing, Zhang, Bingqing

“…BackgroundSpatially resolved gene expression has emerged as a crucial technique to understand complex multicellular interactions within the tumor and its…”
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Whole flaxseed diet alters estrogen metabolism to promote 2-methoxtestradiol-induced apoptosis in hen ovarian cancer by Dikshit, Anushka, Hales, Karen, Hales, Dale Buchanan

“…The study reported here demonstrates that a flaxseed-supplemented diet causes ovarian tumors in the laying hen to undergo apoptosis, resulting in a reduction…”
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RNA-protein Co-detection using spatial analysis to profile tumor-infiltrated immune cells by Dikshit, Anushka, Basak, Sayantani, Doolittle, Emerald, Bunting, Michaeline

“…Abstract Interrogating complex tumor microenvironment requires a multi-omics approach. Detecting target immune cell markers using…”
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Investigating neuroinflammation in the human brain tumor microenvironment using the new RNAscopeTM Multiomic assay by Wakhloo, Debia, Dikshit, Anushka, Kim, Ge-Ah, Yu, Julia, Deshpande, Sonali, Wang, Li-Chong, Srinivasan, Maithreyan

“…Abstract Glioblastomas are one of the most aggressive forms of brain tumors characterized by distinct genetic and molecular signatures. Compared to other solid…”
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Abstract 3306: Conventional type 1 dendritic cells and natural killer cells demonstrate strong correlation to cytotoxic T lymphocyte infiltration in cervical cancer tumors by Dikshit, Anushka, Anderson, Courtney, Zhang, Binqing, Ma, Xiao-Jun

“…Abstract The ability of T cells to mediate anti-tumor immunity has been harnessed to develop some of the most successful immunotherapies in recent years…”
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Multiplexed RNA-protein co-detection to explore tumor-immune landscape using a novel automated RNAscope&[trade] assay by Dikshit, Anushka, Basak, Sayantani, Kim, Ge-Ah, Yu, Julia, Deshpande, Sonali, Wang, Li-Chong, Srinivasan, Maithreyan

“…Abstract Development of next-generation immunotherapies need a highly sensitive multiomics platform to evaluate diagnostic and therapeutic biomarkers. Tissue…”
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Conventional type 1 dendritic cells and natural killer cells demonstrate strong correlation to cytotoxic T lymphocyte infiltration in cervical cancer tumors by Dikshit, Anushka, Anderson, Courtney M, Zhang, Bingqing, Ma, Xiao-Jun

“…Abstract Professional antigen presenting cells such as dendritic cells (DCs) are vital for priming naive CD8+ T cells and developing a sustainable anti-tumor…”
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Spatial profiling of immune cell markers in FFPE tumor tissues using the RNAscope&[trade] HiPlex v2 in situ hybridization assay by Dikshit, Anushka, Basak, Sayantani, Chang, Ching-Wei, Collins, Kim, Bunting, Michaeline

“…Abstract The tumor microenvironment (TME) is highly complex, comprised of tumor cells, immune cells, stromal cells, and extracellular matrix. This study…”
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Multiomic Spatial Phenotyping of the Tumor Immune Microenvironment at Single Cell Resolution by Jhaveri, Niyati, Ji, HaYeun, Dikshit, Anushka, Yuan, Jessica, Doolittle, Emerald, Zhou, Steve, Srinivasan, Maithreyan, Darling, Julia Kennedy, Braubach, Oliver

“…Abstract The Tumor microenvironment (TME) is critical in cancer development, progression, and control. Immunological components within tumors, known as the…”
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Abstract LB235: Characterizing tumor-infiltrated immune cells with spatial context using an integrated RNAscope-immunohistochemistry co-detection workflow in FFPE tissues by Dikshit, Anushka, Phatak, Jyoti, Hernandez, Lydia, Doolittle, Emerald, Murlidhar, Vasudha, Zhang, Bingqing, Ma, Xiao-Jun

“…Abstract Complex tissues such as tumors are comprised of multiple cells types and extracellular matrix. These cells include heterogenous populations of immune…”
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Characterizing tumor-infiltrated immune cells with spatial context using an integrated RNAscope-immunohistochemistry workflow in FFPE tissues by Dikshit, Anushka, Phatak, Jyoti, Hernandez, Lydia, Doolittle, Emerald, Murlidhar, Vasudha, Zhang, Bingqing, Ma, Xiao-Jun

“…Abstract Characterizing heterogenous populations of tumor-infiltrating immune cells requires a multi-omics approach. Here we demonstrate a newly developed…”
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