Search Results - "Diks, Sander H"

IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo by Bralten, Linda B. C., Kloosterhof, Nanne K., Balvers, Rutger, Sacchetti, Andrea, Lapre, Lariesa, Lamfers, Martine, Leenstra, Sieger, de Jonge, Hugo, Kros, Johan M., Jansen, Erwin E. W., Struys, Eduard A., Jakobs, Cornelis, Salomons, Gajja S., Diks, Sander H., Peppelenbosch, Maikel, Kremer, Andreas, Hoogenraad, Casper C., Sillevis Smitt, Peter A. E., French, Pim J.

“…Objective: A high percentage of grade II and III gliomas have mutations in the gene encoding isocitrate dehydrogenase (IDH1). This mutation is always a…”
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Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery by SIKKEMA, Arend H, DIKS, Sander H, PEPPELENBOSCH, Maikel P, DE BONT, Eveline S. J. M, DEN DUNNEN, Wilfred F. A, TER EIST, Arja, SCHERPEN, Frank J. G, HOVING, Eelco W, RUIJTENBEEK, Rob, BOENDER, Piet J, DE WIJN, Rik, KAMPS, Willem A

“…Progression in pediatric brain tumor growth is thought to be the net result of signaling through various protein kinase-mediated networks driving cell…”
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Violacein induces death of resistant leukaemia cells via kinome reprogramming, endoplasmic reticulum stress and Golgi apparatus collapse by Queiroz, Karla C S, Milani, Renato, Ruela-de-Sousa, Roberta R, Fuhler, Gwenny M, Justo, Giselle Z, Zambuzzi, Willian F, Duran, Nelson, Diks, Sander H, Spek, C Arnold, Ferreira, Carmen V, Peppelenbosch, Maikel P

“…It is now generally recognised that different modes of programmed cell death (PCD) are intimately linked to the cancerous process. However, the mechanism of…”
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Staphylococcal PknB as the first prokaryotic representative of the proline-directed kinases by Miller, Malgorzata, Donat, Stefanie, Rakette, Sonja, Stehle, Thilo, Kouwen, Thijs R H M, Diks, Sander H, Dreisbach, Annette, Reilman, Ewoud, Gronau, Katrin, Becher, Dörte, Peppelenbosch, Maikel P, van Dijl, Jan Maarten, Ohlsen, Knut

“…In eukaryotic cell types, virtually all cellular processes are under control of proline-directed kinases and especially MAP kinases. Serine/threonine kinases…”
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Exogenous HGF Bypasses the Effects of ErbB Inhibition on Tumor Cell Viability in Medulloblastoma Cell Lines by Zomerman, Walderik W, Plasschaert, Sabine L A, Diks, Sander H, Lourens, Harm-Jan, Meeuwsen-de Boer, Tiny, Hoving, Eelco W, den Dunnen, Wilfred F A, de Bont, Eveline S J M

“…Recent clinical trials investigating receptor tyrosine kinase (RTK) inhibitors showed a limited clinical response in medulloblastoma. The present study…”
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Are small GTPases signal hubs in sugar-mediated induction of fructan biosynthesis? by Ritsema, Tita, Brodmann, David, Diks, Sander H, Bos, Carina L, Nagaraj, Vinay, Pieterse, Corné M J, Boller, Thomas, Wiemken, Andres, Peppelenbosch, Maikel P

“…External sugar initiates biosynthesis of the reserve carbohydrate fructan, but the molecular processes mediating this response remain obscure. Previously it…”
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Kinome Profiling for Studying Lipopolysaccharide Signal Transduction in Human Peripheral Blood Mononuclear Cells by Diks, Sander H, Kok, Klaartje, O'Toole, Tom, Hommes, Daan W, van Dijken, Peter, Joore, Jos, Peppelenbosch, Maikel P

“…The DNA array technique allows comprehensive analysis of the genome and transcriptome, but the high throughput array-based assessment of intracellular signal…”
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Kinase activity profiling of pneumococcal pneumonia by Hoogendijk, Arie J, Diks, Sander H, van der Poll, Tom, Peppelenbosch, Maikel P, Wieland, Catharina W

“…Pneumonia represents a major health burden. Previous work demonstrated that although the induction of inflammation is important for adequate host defense…”
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Essential role for the d-Asb11 cul5 Box domain for proper notch signaling and neural cell fate decisions in vivo by Sartori da Silva, Maria A, Tee, Jin-Ming, Paridaen, Judith, Brouwers, Anke, Runtuwene, Vincent, Zivkovic, Danica, Diks, Sander H, Guardavaccaro, Daniele, Peppelenbosch, Maikel P

“…ECS (Elongin BC-Cul2/Cul5-SOCS-box protein) ubiquitin ligases recruit substrates to E2 ubiquitin-conjugating enzymes through a SOCS-box protein substrate…”
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Evidence for a minimal eukaryotic phosphoproteome? by Diks, Sander H, Parikh, Kaushal, van der Sijde, Marijke, Joore, Jos, Ritsema, Tita, Peppelenbosch, Maikel P

“…Reversible phosphorylation catalysed by kinases is probably the most important regulatory mechanism in eukaryotes. We studied the in vitro phosphorylation of…”
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Comparison of peptide array substrate phosphorylation of c-Raf and mitogen activated protein kinase kinase kinase 8 by Parikh, Kaushal, Diks, Sander H, Tuynman, Jurriaan H B, Verhaar, Auke, Löwenberg, Mark, Hommes, Daan W, Joore, Jos, Pandey, Akhilesh, Peppelenbosch, Maikel P

“…Kinases are pivotal regulators of cellular physiology. The human genome contains more than 500 putative kinases, which exert their action via the…”
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The novel gene asb11: a regulator of the size of the neural progenitor compartment by Diks, Sander H, Bink, Robert J, van de Water, Sandra, Joore, Jos, van Rooijen, Carina, Verbeek, Fons J, den Hertog, Jeroen, Peppelenbosch, Maikel P, Zivkovic, Danica

“…From a differential display designed to isolate genes that are down-regulated upon differentiation of the central nervous system in Danio rerio embryos, we…”
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Identification of new possible targets for leukemia treatment by kinase activity profiling by Ter Elst, Arja, Diks, Sander H., Kampen, Kim R., Hoogerbrugge, Peter M., Ruijtenbeek, Rob, Boender, Piet J., Sikkema, Arend H., Scherpen, Frank J. G., Kamps, Willem A., Peppelenbosch, Maikel P., de Bont, Eveline S. J. M.

“…To date, the biology of acute leukemia has been unclear, and defining new therapeutic targets without prior knowledge remains complicated. The use of…”
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PTK787/ZK 222584 inhibits tumor growth promoting mesenchymal stem cells: Kinase activity profiling as powerful tool in functional studies by Roorda, Berber, Elst, Arja ter, Diks, Sander H., Meeuwsen-de Boer, Tiny G. J., Kamps, Willem A., de Bont, Eveline S. J. M.

“…Bone marrow (BM)-derived mesenchymal stem cells (MSCs) have been shown to favour tumor growth, suggesting the relevance of pharmaceutical inhibition of MSCs…”
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EphB2 activity plays a pivotal role in pediatric medulloblastoma cell adhesion and invasion by Sikkema, Arend H, den Dunnen, Wilfred F A, Hulleman, Esther, van Vuurden, Dannis G, Garcia-Manero, Guillermo, Yang, Hui, Scherpen, Frank J G, Kampen, Kim R, Hoving, Eelco W, Kamps, Willem A, Diks, Sander H, Peppelenbosch, Maikel P, de Bont, Eveline S J M

“…Eph/ephrin signaling has been implicated in various types of key cancer-enhancing processes, like migration, proliferation, and angiogenesis. In…”
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Protein phosphatase 2A is required for mesalazine-dependent inhibition of Wnt/β-catenin pathway activity by Bos, Carina L., Diks, Sander H., Hardwick, James C.H., Walburg, Kimberley V., Peppelenbosch, Maikel P., Richel, Dick J.

“…The rising incidence and poor prognosis of colorectal cancer have aroused substantial interest in novel chemopreventive strategies. Interestingly, treatment of…”
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Kinase activity profiling reveals active signal transduction pathways in pediatric acute lymphoblastic leukemia: A new approach for target discovery by van der Sligte, Naomi E., Scherpen, Frank J. G., Meeuwsen-de Boer, Tiny G. J., Lourens, Harm Jan, ter Elst, Arja, Diks, Sander H., Guryev, Victor, Peppelenbosch, Maikel P., van Leeuwen, Frank N., de Bont, Eveline S. J. M.

“…Still about 20% of patients with acute lymphoblastic leukemia (ALL) struggle with relapse, despite intensive chemotherapy. We and others have shown that kinase…”
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Comparison of kinome profiles of Barrett's esophagus with normal squamous esophagus and normal gastric cardia by VAN BAA, Jantine W. P. M, DIKS, Sander H, WANDERS, Ronald J. A, RYGIEL, Agnieskza M, MILANO, Francesca, JOORE, Jos, BERGMAN, Jacques J. G. H. M, PEPPELENBOSCH, Maikel P, KRISHNADATH, Kausilia K

“…The precursor metaplastic mucosal lesion that predisposes for esophageal adenocarcinoma is Barrett's esophagus. Because the signal transduction events that…”
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Acute stress elicited by bungee jumping suppresses human innate immunity by van Westerloo, David J, Choi, Goda, Löwenberg, Ester C, Truijen, Jasper, de Vos, Alex F, Endert, Erik, Meijers, Joost C M, Zhou, Lu, Pereira, Manuel P F L, Queiroz, Karla C S, Diks, Sander H, Levi, Marcel, Peppelenbosch, Maikel P, van der Poll, Tom

“…Although a relation between diminished human immunity and stress is well recognized both within the general public and the scientific literature, the molecular…”
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Kinase activity profiling of gram-negative pneumonia by Hoogendijk, Arie J, Diks, Sander H, Peppelenbosch, Maikel P, Van Der Poll, Tom, Wieland, Catharina W

“…Pneumonia is a severe disease with high morbidity and mortality. A major causative pathogen is the Gram-negative bacterium Klebsiella (K.) pneumoniae. Kinases…”
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