Search Results - "Diks, S. H."

Effect of aspirin on the Wnt/β-catenin pathway is mediated via protein phosphatase 2A by BOS, C. L, KODACH, L. L, VAN DEN BRINK, G. R, DIKS, S. H, VAN SANTEN, M. M, RICHEL, D. J, PEPPELENBOSCH, M. P, HARDWICK, J. C. H

“…Nonsteroidal anti-inflammatory drugs show chemopreventive efficacy in colon cancer, but the mechanism behind this remains unclear. Elucidating this mechanism…”
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Vascular endothelial growth factor receptor 2 (VEGFR-2) signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells by Sikkema, A. H., de Bont, E. S. J. M., Molema, G., Dimberg, A., Zwiers, P. J., Diks, S. H., Hoving, E. W., Kamps, W. A., Peppelenbosch, M. P., den Dunnen, W. F. A.

“…A. H. Sikkema, E. S. J. M. de Bont, G. Molema, A. Dimberg, P. J. Zwiers, S. H. Diks, E. W. Hoving, W. A. Kamps, M. P. Peppelenbosch and W. F. A. den Dunnen…”
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Insights in dynamic kinome reprogramming as a consequence of MEK inhibition in MLL-rearranged AML by Kampen, K R, ter Elst, A, Mahmud, H, Scherpen, F J G, Diks, S H, Peppelenbosch, M P, de Haas, V, Guryev, V, de Bont, E S J M

“…Single kinase-targeted cancer therapies often failed prolonged responses because cancer cells bypass through alternative routes. In this study, high-throughput…”
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Factor VIIa/Tissue Factor-induced Signaling via Activation of Src-like Kinases, Phosphatidylinositol 3-Kinase, and Rac by Versteeg, H H, Hoedemaeker, I, Diks, S H, Stam, J C, Spaargaren, M, van Bergen En Henegouwen, P M, van Deventer, S J, Peppelenbosch, M P

“…Tissue factor (TF), apart from activating the extrinsic pathway of the blood coagulation, is a principal regulator of embryonic angiogenesis and oncogenic…”
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Glucosylceramide Synthase Does Not Attenuate the Ceramide Pool Accumulating during Apoptosis Induced by CD95 or Anti-cancer Regimens by Tepper, Annemiek D., Diks, Sander H., van Blitterswijk, Wim J., Borst, Jannie

“…Ceramide (Cer) accumulating during the execution phase of apoptosis is generated from plasma membrane sphingomyelin (SM), which gains access to a…”
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Lipopolysaccharide recognition, internalisation, signalling and other cellular effects by Diks, S H, van Deventer, S J, Peppelenbosch, M P

“…Despite the importance of bacterial lipopolysaccharide (LPS) in infection and inflammation, many aspects of LPS action remain poorly understood. Especially,…”
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Effect of aspirin on the Wnt/b-catenin pathway is mediated via protein phosphatase 2A by Bos, C L, Kodach, L L, van den Brink, G R, Diks, S H, van Santen, M M, Richel, D J, Peppelenbosch, M P, Hardwick, J C H

“…Nonsteroidal anti-inflammatory drugs show chemopreventive efficacy in colon cancer, but the mechanism behind this remains unclear. Elucidating this mechanism…”
Get full text

Effect of aspirin on the Wnt -catenin pathway is mediated via protein phosphatase 2A by Bos, C L, Kodach, L L, G R van den Brink, Diks, S H, van Santen, M M, Richel, D J, Peppelenbosch, M P, Hardwick, J C H

“…Nonsteroidal anti-inflammatory drugs show chemopreventive efficacy in colon cancer, but the mechanism behind this remains unclear. Elucidating this mechanism…”
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Protein phosphatase 2A is required for mesalazine-dependent inhibition of Wnt/ -catenin pathway activity by Bos, C. L., Diks, S. H., Hardwick, J. C.H., Walburg, K. V., Peppelenbosch, M. P., Richel, D. J.

“…The rising incidence and poor prognosis of colorectal cancer have aroused substantial interest in novel chemopreventive strategies. Interestingly, treatment of…”
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Kinome Profiling for Studying Lipopolysaccharide Signal Transduction in Human Peripheral Blood Mononuclear Cells by Diks, Sander H, Kok, Klaartje, O'Toole, Tom, Hommes, Daan W, van Dijken, Peter, Joore, Jos, Peppelenbosch, Maikel P

“…The DNA array technique allows comprehensive analysis of the genome and transcriptome, but the high throughput array-based assessment of intracellular signal…”
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Single cell proteomics for personalised medicine by Diks, Sander H., Peppelenbosch, Maikel P.

“…Recently, multicolour FACS combined with phosphospecific antibodies has been developed, enabling the determination of the relative phosphorylation of signal…”
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LPS signal transduction: the picture is becoming more complex by Diks, Sander H, Richel, Dick J, Peppelenbosch, Maikel P

“…Lipopolysaccharide (LPS) is the principal initiator of septic shock and it is to a large extent responsible for post-operative mortality. The use of…”
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Activation of the Canonical β-Catenin Pathway by Histamine by Diks, Sander H., Hardwick, James C., Diab, Remco M., van Santen, Marije M., Versteeg, Henri H., van Deventer, Sander J.H., Richel, Dick J., Peppelenbosch, Maikel P.

“…Histamine signaling is a principal regulator in a variety of pathophysiological processes including inflammation, gastric acid secretion, neurotransmission,…”
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Tetrahydroxyquinone induces apoptosis of leukemia cells through diminished survival signaling by Martins Cavagis, Alexandre D., Ferreira, Carmen Veríssima, Versteeg, Henri H., Assis, Cristiane Fernandes, Bos, Carina L., Bleuming, Sylvia A., Diks, Sander H., Aoyama, Hiroshi, Peppelenbosch, Maikel P.

“…Tetrahydroxyquinone is a molecule best known as a primitive anticataract drug but is also a highly redox active molecule that can take part in a redox cycle…”
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