Search Results - "Dikic, I"

Ubiquitination and selective autophagy by Shaid, S, Brandts, C H, Serve, H, Dikic, I

“…Ubiquitination has long been recognised as a key determinator of protein fate by tagging proteins for proteasomal degradation. Most recently, the ability of…”
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Mechanisms controlling EGF receptor endocytosis and degradation by Dikic, I

“…Activated EGF (epidermal growth factor) receptors are removed from the cell surface via endocytosis and subsequent degradation in the lysosome. This ultimately…”
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Deubiquitinase USP10 regulates Notch signaling in the endothelium by Lim, R, Sugino, T, Nolte, H, Andrade, J, Zimmermann, B, Shi, C, Doddaballapur, A, Ong, Y T, Wilhelm, K, Fasse, J W D, Ernst, A, Kaulich, M, Husnjak, K, Boettger, T, Guenther, S, Braun, T, Krüger, M, Benedito, R, Dikic, I, Potente, M

“…Notch signaling is a core patterning module for vascular morphogenesis that codetermines the sprouting behavior of endothelial cells (ECs). Tight quantitative…”
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Ubiquitin binding mediates the NF-κB inhibitory potential of ABIN proteins by Wagner, S, Carpentier, I, Rogov, V, Kreike, M, Ikeda, F, Löhr, F, Wu, C-J, Ashwell, J D, Dötsch, V, Dikic, I, Beyaert, R

“…Deregulated nuclear factor κB (NF-κB) activation plays an important role in inflammation and tumorigenesis. ABIN proteins have been characterized as negative…”
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Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression by Pareja, F, Ferraro, D A, Rubin, C, Cohen-Dvashi, H, Zhang, F, Aulmann, S, Ben-Chetrit, N, Pines, G, Navon, R, Crosetto, N, Köstler, W, Carvalho, S, Lavi, S, Schmitt, F, Dikic, I, Yakhini, Z, Sinn, P, Mills, G B, Yarden, Y

“…Once stimulated, the epidermal growth factor receptor (EGFR) undergoes self-phosphorylation, which, on the one hand, instigates signaling cascades, and on the…”
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Adaptor Proteins Grb2 and Crk Couple Pyk2 with Activation of Specific Mitogen-activated Protein Kinase Cascades by Blaukat, Andree, Ivankovic-Dikic, Inga, Grönroos, Eva, Dolfi, Fabrizio, Tokiwa, George, Vuori, Kristiina, Dikic, Ivan

“…The protein tyrosine kinase Pyk2 acts as an upstream regulator of mitogen-activated protein (MAP) kinase cascades in response to numerous extracellular…”
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Cbl signaling networks in the regulation of cell function by Dikic, I, Szymkiewicz, I, Soubeyran, P

“…Cbl proteins control multiple cellular processes by acting as ubiquitin ligases and multifunctional adaptor molecules. They are involved in the control of cell…”
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A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation by Dikic, Ivan, Tokiwa, George, Lev, Sima, Courtneidge, Sara A, Schlessinger, Joseph

“…The mechanisms by which mitogenic G-protein-coupled receptors activate the MAP kinase signalling pathway are poorly understood. Candidate protein tyrosine…”
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Activation of Pyk2 by Stress Signals and Coupling with JNK Signaling Pathway by Tokiwa, G., Dikic, I., Lev, S., Schlessinger, J.

“…The c-Jun amino-terminal kinase (JNK) is activated by various heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors, inflammatory…”
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266 TAX1BP1 LIMITS TUMOR FORMATION IN EXPERIMENTAL LIVER CANCER by Waidmann, O, Piiper, A, Zeuzem, S, Dikic, I

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Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation by Spivak-Kroizman, T, Lemmon, M A, Dikic, I, Ladbury, J E, Pinchasi, D, Huang, J, Jaye, M, Crumley, G, Schlessinger, J, Lax, I

“…Heparin is required for fibroblast growth factor (FGF) stimulation of biological responses. Using isothermal titration calorimetry, we show that acidic FGF…”
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Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction by Mohammadi, M., Dikic, I., Sorokin, A., Burgess, W. H., Jaye, M., Schlessinger, J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins by Dikic, Ivan, Ivankovic-Dikic, Inga, Grönroos, Eva, Blaukat, Andree, Barth, Bernd-Uwe

“…Integration of signalling pathways initiated by receptor tyrosine kinases and integrins is essential for growth-factor-mediated biological responses. Here we…”
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Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule βPix by SCHMIDT, M. H. H, HUSNJAK, K, SZYMKIEWICZ, I, HAGLUND, K, DIKIC, I

“…The Pix/Cool proteins are involved in the regulation of cell morphology by binding to small Rho GTPases and kinases of the Pak family. Recently, it has been…”
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Cdx1 promotes differentiation in a rat intestinal epithelial cell line by Soubeyran, Philippe, André, Frédéric, Lissitzky, Jean-Claude, Mallo, Gustavo Vidal, Moucadel, Virginie, Roccabianca, Monique, Rechreche, Hocine, Marvaldi, Jacques, Dikic, Ivan, Dagorn, Jean-Charles, Iovanna, Juan Lucio

“…Background & Aims: Homeobox genes are involved in establishing and maintaining differentiated patterns in adult tissues. Cdx1 might carry out that function in…”
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Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway by Miyazaki, T, Takaoka, A, Nogueira, L, Dikic, I, Fujii, H, Tsujino, S, Mitani, Y, Maeda, M, Schlessinger, J, Taniguchi, T

“…Many cytokines transmit signals to the cell interior through activation of receptor-associated, Janus family protein tyrosine kinases (Jak PTKs). The…”
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Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase   in Saccharomyces cerevisiae by Parker, J. L., Bielen, A. B., Dikic, I., Ulrich, H. D.

“…Bypassing of DNA lesions by damage-tolerant DNA polymerases depends on the interaction of these enzymes with the monoubiquitylated form of the replicative…”
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Expression of the CD2AP adaptor molecule in normal, reactive and neoplastic human tissue by Rizvi, H, Paterson, J C, Tedoldi, S, Ramsay, A, Calaminici, M, Natkunam, Y, Lonardi, S, Tan, S-Y, Campbell, L, Hansmann, M-L, Jones, D, Dikic, I, Shaw, A S, Pileri, S A, Stein, H, Mason, D Y, Facchetti, F, Marafioti, T

“…To study the expression of CD2-associated protein (CD2AP), an adaptor protein involved in T-cell signalling and renal function, in normal, reactive and…”
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1033 Study of adapter protein Ruk/CIN85 subcellular redistribution after stimulation of HeLa cells with activators of PI3K by Basaraba, O, Kozlova, N, Pasichnyk, A, Dikic, I, Drobot, L

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Common Molecular Pathways in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia by Weishaupt, Jochen H, Hyman, Tony, Dikic, Ivan

“…Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related neurodegenerative diseases in which predominantly motor neurons and…”
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