Donors with repeated blood product discards for filtration problems, clots or hemolysis: Causes and follow‐up

Donors with repeated blood product discards for filtration problems, clots or hemolysis: Causes and follow‐up

Introduction Sanquin donor medicine department is informed when donations or their components are rejected. This can occur isolated or frequently. It is undesirable because the donations cannot be used and there may be an underlying medical cause. Based on regional approaches, a uniform procedure wa...

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Bibliographic Details
Published in:Transfusion (Philadelphia, Pa.) Vol. 64; no. 4; pp. 572 - 577
Main Authors: Díaz Padilla, Niubel, Wiersum‐Osselton, Johanna C, Ghasemi Nezjad, Shahryar, Dijkshoorn, Gitta, Gonzalez‐Garcia, Fernando, Novotny, Vĕra M. J.
Format: Journal Article
Language:English
Published: Hoboken, USA John Wiley & Sons, Inc 01-04-2024
Wiley Subscription Services, Inc
Subjects:
Blood
Blood & organ donations
Blood Banks
blood component preparations
Blood Donors
blood management
Components
discarded products
Discards
donors
Filtration
filtration failure
Follow-Up Studies
Hemolysis
Humans
Information systems
Plateletpheresis
Policies
Regional development
Rejection
sickle cell trait
Surveys
filtration failure
donors
blood component preparations
blood management
discarded products
sickle cell trait
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Summary:Introduction Sanquin donor medicine department is informed when donations or their components are rejected. This can occur isolated or frequently. It is undesirable because the donations cannot be used and there may be an underlying medical cause. Based on regional approaches, a uniform procedure was developed. Methods Information about whole blood, plasma‐ plateletpheresis donations from which one or more components were rejected for filtration time (>2 h), hemolysis or clots were extracted from blood bank information system. After rejection of two successive components or donations or total ≥3 the donor is contacted. Depending on the medical history and investigation by the family doctor, the donor carrier is re‐evaluated. We looked for the causes of the discarded products and performed a survey among blood services regarding polices with discarded products. Results One or more components from 1742 of about 2.2 million successful donations (0.08%) were rejected. The highest percentage of rejection was seen in plateletpheresis (1.5%), all for clots. No underlying medical causes were found. 24 whole blood donors were found to have sickle cell trait (SCT) and were permanently deferred. The policies for follow‐up after discarded products or acceptance of SCT donors vary between the 16 blood banks. Six organizations do not follow‐up donors and seven accept SCT for blood or plasma donation. Conclusion Informing donors with repeated discarded products avoids the non‐use of donations. Causes of repeated discarded products can be found by follow‐up of donors. The results of the survey indicate a large discrepancy in policies applied worldwide.
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ISSN:0041-1132
1537-2995
DOI:10.1111/trf.17763