Search Results - "Digweed, Dena"

Absorption and tolerability of taste‐masked hydrocortisone granules in neonates, infants and children under 6 years of age with adrenal insufficiency by Neumann, Uta, Whitaker, Martin J., Wiegand, Susanna, Krude, Heiko, Porter, John, Davies, Madhu, Digweed, Dena, Voet, Bernard, Ross, Richard J., Blankenstein, Oliver

“…Summary Objectives There is no licensed, dose‐appropriate formulation of hydrocortisone for children with adrenal insufficiency (AI) and patients rely on…”
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A Prospective Study of Children Aged 0–8 Years with CAH and Adrenal Insufficiency Treated with Hydrocortisone Granules by Neumann, Uta, Braune, Katarina, Whitaker, Martin J, Wiegand, Susanna, Krude, Heiko, Porter, John, Digweed, Dena, Voet, Bernard, Ross, Richard J M, Blankenstein, Oliver

“…Abstract Context Children with congenital adrenal hyperplasia (CAH) and adrenal insufficiency (AI) require daily hydrocortisone replacement with accurate…”
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A Phase 2 Study of Chronocort, a Modified-Release Formulation of Hydrocortisone, in the Treatment of Adults With Classic Congenital Adrenal Hyperplasia by Mallappa, Ashwini, Sinaii, Ninet, Kumar, Parag, Whitaker, Martin J, Daley, Lori-Ann, Digweed, Dena, Eckland, David J. A, Van Ryzin, Carol, Nieman, Lynnette K, Arlt, Wiebke, Ross, Richard J, Merke, Deborah P

“…Context: Treatment of congenital adrenal hyperplasia (CAH) is suboptimal. Inadequate suppression of androgens and glucocorticoid excess are common and current…”
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Development and Testing in Healthy Adults of Oral Hydrocortisone Granules With Taste Masking for the Treatment of Neonates and Infants With Adrenal Insufficiency by Whitaker, Martin J, Spielmann, Sarah, Digweed, Dena, Huatan, Hiep, Eckland, David, Johnson, Trevor N, Tucker, Geoffrey, Krude, Heiko, Blankenstein, Oliver, Ross, Richard J

“…Background: Treatment of neonates and infants with adrenal insufficiency is unsatisfactory because unlicensed hydrocortisone formulations are used. Objectives:…”
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Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo by Nikolaou, Nikolaos, Arvaniti, Anastasia, Appanna, Nathan, Sharp, Anna, Hughes, Beverly A, Digweed, Dena, Whitaker, Martin J, Ross, Richard, Arlt, Wiebke, Penning, Trevor M, Morris, Karen, George, Sherly, Keevil, Brian G, Hodson, Leanne, Gathercole, Laura L, Tomlinson, Jeremy W

“…Steroid 5β-reductase (AKR1D1) is highly expressed in human liver where it inactivates endogenous glucocorticoids and catalyses an important step in bile acid…”
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Hydrocortisone Granules Are Bioequivalent When Sprinkled Onto Food or Given Directly on the Tongue by Daniel, Eleni, Digweed, Dena, Quirke, Jo, Voet, Bernard, Ross, Richard J, Davies, Madhu

“…Abstract Background Immediate-release hydrocortisone granules in capsules for opening in pediatric-appropriate doses have recently been licensed for children…”
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