Search Results - "Digiusto, D"

Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion by Kumar, B, Garcia, M, Weng, L, Jung, X, Murakami, J L, Hu, X, McDonald, T, Lin, A, Kumar, A R, DiGiusto, D L, Stein, A S, Pullarkat, V A, Hui, S K, Carlesso, N, Kuo, Y-H, Bhatia, R, Marcucci, G, Chen, C-C

“…Little is known about how leukemia cells alter the bone marrow (BM) niche to facilitate their own growth and evade chemotherapy. Here, we provide evidence that…”
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Detection of replication competent lentivirus using a qPCR assay for VSV-G by Skrdlant, L, Keidaisch, B, Lorente, M, DiGiusto, D

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Manufacturing of gene-modified cytotoxic T lymphocytes for autologous cellular therapy for lymphoma by Cooper, L.J.N., Ausubel, L., Gutierrez, M., Stephan, S., Shakeley, R., Olivares, S., Serrano, L.M., Burton, L., Jensen, M.C.V., Forman, S.J., Digiusto, D.L.

“…The production of therapeutic T-cell populations for adoptive immunotherapy of cancer requires extensive ex vivo cell processing, including the isolation or…”
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Preparing clinical grade Ag-specific T cells for adoptive immunotherapy trials by Digiusto, D.L., PhD, Cooper, L.J.N., MD, PhD

“…The production of clinical-grade T cells for adoptive immunotherapy has evolved from the ex vivo numerical expansion of tumor-infiltrating lymphocytes to…”
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Hematopoietic Potential of Cryopreserved and Ex Vivo Manipulated Umbilical Cord Blood Progenitor Cells Evaluated In Vitro and In Vivo by DiGiusto, David L., Lee, Robert, Moon, James, Moss, Katherine, O'Toole, Tom, Voytovich, Amy, Webster, Donna, Mule, James J.

“…The hematopoietic potential of cryopreserved and ex vivo manipulated umbilical cord blood (UCB) samples was evaluated in vitro and in vivo. Phenotypic analysis…”
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280 - Detection of replication competent lentivirus using a qPCR assay for VSV-G by Skrdlant, L., Keidaisch, B., Lorente, M., DiGiusto, D.

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Sustained retroviral gene marking and expression in lymphoid and myeloid cells derived from transduced hematopoietic progenitor cells by Plavec, I, Voytovich, A, Moss, K, Webster, D, Hanley, M B, Escaich, S, Ho, K E, Böhnlein, E, DiGiusto, D L

“…The expression of antiviral genes in human hematopoietic stem or progenitor cells has been proposed as a strategy for gene therapy of AIDS. To be successful,…”
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Single cell analysis of calcium mobilization in anti-immunoglobulin- stimulated B lymphocytes by Ransom, JT, DiGiusto, DL, Cambier, JC

“…A rapid increase in the concentration of intracellular free calcium ([Ca++i]) in B cells after mIg crosslinking has been documented previously by fluorimetric…”
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Endogenous MCM7 microRNA cluster as a novel platform to multiplex small interfering and nucleolar RNAs for combinational HIV-1 gene therapy by Chung, Janet, Zhang, Jane, Li, Haitang, Ouellet, Dominique L, DiGiusto, David L, Rossi, John J

“…Combinational therapy with small RNA inhibitory agents against multiple viral targets allows efficient inhibition of viral production by controlling gene…”
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mIgM:mIgD ratios on B cells: mean mIgD expression exceeds mIgM by 10- fold on most splenic B cells by Havran, WL, DiGiusto, DL, Cambier, JC

“…The relative frequency of mIgM and mIgD molecules on B cell surfaces is important in determining, in large part, the isotype involvement in antigen binding and…”
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Manufacturing of large numbers of patient-specific T cells for adoptive immunotherapy : An approach to improving product safety, composition, and production capacity by TRAN, Chy-Anh, BURTON, Luciana, RUSSOM, Diana, WAGNER, Jamie R, JENSEN, Michael C, FORMAN, Stephen J, DIGIUSTO, David L

“…We have developed an innovative system for ex vivo processing of patient-specific cell products to produce large numbers of T-lymphocytes in support of phase 2…”
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Development and application of CD19-specific T cells for adoptive immunotherapy of B cell malignancies by Cooper, Laurence J.N., Al-Kadhimi, Zaid, DiGiusto, David, Kalos, Michael, Colcher, David, Raubitschek, Andrew, Forman, Steve J., Jensen, Michael C.

“…The graft-versus-leukemia (GVL)-effect achieved by donor-derived T cells arising from transplanted allogeneic hematopoietic stem cells or given as…”
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Residues of the variable region of the T-cell-receptor β-chain that interact with S. aureus toxin superantigens by Choi, Yongwon, Herman, Andrew, DiGiusto, David, Wade, Terri, Marrack, Philippa, Kappler, John

“…The alpha beta T-cell antigen receptor (TCR) recognizes antigenic peptides in the context of self major histocompatibility complex (MHC) molecules. The…”
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Ex vivo expansion of transplantable human hematopoietic stem cells: where do we stand in the year 2000? by Shih, C C, DiGiusto, D, Forman, S J

“…Ex vivo expansion of hematopoietic precursors, progenitors and stem cells represents the modern era of cellular therapeutics in the 21st century. For the last…”
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Analysis of human hematopoietic stem cell populations by Murray, L, DiGiusto, D, Chen, B, Chen, S, Combs, J, Conti, A, Galy, A, Negrin, R, Tricot, G, Tsukamoto, A

“…Purification of human hematopoietic stem cells (HSC) may be useful clinically for preparation of tumor-free grafts to be used for autologous transplantation…”
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Flow cytometric analysis of intracellular calcium mobilization by Ransom, J T, DiGiusto, D L, Cambier, J

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Human fetal bone marrow early progenitors for T, B, and myeloid cells are found exclusively in the population expressing high levels of CD34 by DIGIUSTO, D, CHEN, S, COMBS, J, WEBB, S, NAMIKAWA, R, TSUKAMOTO, A, CHEN, B. P, GALY, A. H. M

“…Experimentation on human stem cells is hampered by the relative paucity of this population and by the lack of assays identifying multilineage differentiation,…”
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Retention of Quiescent Hematopoietic Cells With High Proliferative Potential During Ex Vivo Stem Cell Culture by Young, Judy C., Varma, Amit, DiGiusto, David, Backer, Mark P.

“…Human CD34+/Thy-1+/Lin- hematopoietic cells purified from bone marrow (BM) or mobilized peripheral blood (MPB) are highly enriched for pluripotent stem cells…”
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Hematopoietic Potential of Neural Stem Cells: Plasticity Versus Heterogeneity by Shih, Chu-chih, DiGiusto, David, Mamelak, Adam, LeBon, Thomas, Forman, Stephen J.

“…Organ-specific stem cells have been identified in a variety of mammalian tissues. These cells hold great promise for cellular therapy if they can reliably…”
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An analysis of sequence variation in the beta chain framework and complementarity determining regions of an allo-reactive T cell receptor by DiGiusto, D L, Palmer, E

“…Current models of T cell receptor (TCR) structure are generally based on the homology observed between the TCR and the immunoglobulins. Furthermore, these…”
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