Search Results - "Dighe, Abhijit S."

A review of UHMWPE wear-induced osteolysis： the role for early detection of the immune response by Kandahari, Adrese M, Yang, Xinlin, Laroche, Kevin A, Dighe, Abhijit S, Pan, Dongfeng, Cui, Quanjun

“…In a world where increasing joint arthroplasties are being performed on increasingly younger patients, osteolysis as the leading cause of faiIure after total…”
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Interactions between MSCs and Immune Cells: Implications for Bone Healing by Cui, Quanjun, Lobo, Peter I., Dighe, Abhijit S., Kovach, Tracy K.

“…It is estimated that, of the 7.9 million fractures sustained in the United States each year, 5% to 20% result in delayed or impaired healing requiring…”
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Cross-Talk Between VEGF and BMP-6 Pathways Accelerates Osteogenic Differentiation of Human Adipose-Derived Stem Cells by Li, Ching-Ju, Madhu, Vedavathi, Balian, Gary, Dighe, Abhijit S., Cui, Quanjun

“…Deficiency in vascular endothelial growth factor (VEGF) or bone morphogenetic proteins (BMPs) results in fracture non‐unions. Therefore, it is indispensable to…”
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Combined angiogenic and osteogenic factor delivery for bone regenerative engineering by Cui, Quanjun, Dighe, Abhijit S, Irvine, Jr, James N

“…Both osteogenesis and angiogenesis are integrated parts of bone growth and regeneration. Combined delivery of osteogenic and angiogenic factors is a novel…”
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Correction: BMP-Non-Responsive Sca1+CD73+CD44+ Mouse Bone Marrow Derived Osteoprogenitor Cells Respond to Combination of VEGF and BMP-6 to Display Enhanced Osteoblastic Differentiation and Ectopic Bone Formation by Madhu, Vedavathi, Li, Ching-Ju, Dighe, Abhijit S, Balian, Gary, Cui, Quanjun

“…[This corrects the article DOI: 10.1371/journal.pone.0103060.]…”
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Recognition of Immune Response for the Early Diagnosis and Treatment of Osteoarthritis by Pan, Dongfeng, Dighe, Abhijit S., Yang, Xinlin, Kandahari, Adrese M., Cui, Quanjun

“…Osteoarthritis is a common and debilitating joint disease that affects up to 30 million Americans, leading to significant disability, reduction in quality of…”
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BMP-6 promotes type 2 immune response during enhancement of rat mandibular bone defect healing by McColl, Logan F, Chen, Xizhao, Solga, Michael D, Schlegel, Kailo, Haughey, Sean P, Lobo, Peter I, Fread, Kristen, Zunder, Eli, Cha, Ryan, Park, Stephen, Christophel, J Jared, Cui, Quanjun, Dighe, Abhijit S

“…Bone morphogenetic proteins (BMPs) are used as key therapeutic agents for the treatment of difficult fractures. While their effects on osteoprogenitors are…”
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Dual Inhibition of Activin/Nodal/TGF-β and BMP Signaling Pathways by SB431542 and Dorsomorphin Induces Neuronal Differentiation of Human Adipose Derived Stem Cells by Deal, D. Nicole, Cui, Quanjun, Dighe, Abhijit S., Madhu, Vedavathi

“…Damage to the nervous system can cause devastating diseases or musculoskeletal dysfunctions and transplantation of progenitor stem cells can be an excellent…”
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Inhibition of differentiation and function of osteoclasts by dimethyl sulfoxide (DMSO) by Yang, Chunxi, Madhu, Vedavathi, Thomas, Candace, Yang, Xinlin, Du, Xeujun, Dighe, Abhijit S, Cui, Quanjun

“…Dimethyl sulfoxide (DMSO) is an FDA-approved organosulfur solvent that is reported to have therapeutic value in osteoarthritis and osteopenia. DMSO is used as…”
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BMP-non-responsive Sca1+ CD73+ CD44+ mouse bone marrow derived osteoprogenitor cells respond to combination of VEGF and BMP-6 to display enhanced osteoblastic differentiation and ectopic bone formation by Madhu, Vedavathi, Li, Ching-Ju, Dighe, Abhijit S, Balian, Gary, Cui, Quanjun

“…Clinical trials on fracture repair have challenged the effectiveness of bone morphogenetic proteins (BMPs) but suggest that delivery of mesenchymal stem cells…”
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Adenoviral Delivery of the VEGF and BMP-6 Genes to Rat Mesenchymal Stem Cells Potentiates Osteogenesis by Seamon, Jesse, Wang, Xiuli, Cui, Fuai, Keller, Tom, Dighe, Abhijit S., Balian, Gary, Cui, Quanjun

“…The combined delivery of mesenchymal stem cells (MSCs), vascular endothelial growth factor (VEGF), and bone morphogenetic protein (BMP) to sites of bone injury…”
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Interferon gamma and T cells inhibit osteogenesis induced by allogeneic mesenchymal stromal cells by Dighe, Abhijit S., Yang, Scott, Madhu, Vedavathi, Balian, Gary, Cui, Quanjun

“…The mesenchymal stromal cells (MSCs) are reported to be immunoprivileged and osteogenic. We hypothesized that the use of allogeneic MSCs for bone repair was…”
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Poly(lactic-co-glycolide) polymer constructs cross-linked with human BMP-6 and VEGF protein significantly enhance rat mandible defect repair by Das, Anusuya, Fishero, Brian A., Christophel, J. Jared, Li, Ching-Ju, Kohli, Nikita, Lin, Yong, Dighe, Abhijit S., Cui, Quanjun

“…We have previously shown that the combined delivery of mesenchymal stem cells (MSCs), vascular endothelial growth factor (VEGF) and bone morphogenetic protein…”
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Expression of CD105 and CD34 receptors controls BMP-induced in vitro mineralization of mouse adipose-derived stem cells but does not predict their in vivo bone-forming potential by Madhu, Vedavathi, Kilanski, Allison, Reghu, Nikitha, Dighe, Abhijit S., Cui, Quanjun

“…ABSTRACT Adipose‐derived stem cells (ADSCs) can be excellent alternative to bone marrow derived stem cells for enhancing fracture repair since ADSCs can be…”
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Assessment of Hedgehog Signaling Pathway Activation for Craniofacial Bone Regeneration in a Critical-Sized Rat Mandibular Defect by Miller, Matthew Q, McColl, Logan F, Arul, Michael R, Nip, Jonathan, Madhu, Vedavathi, Beck, Gina, Mathur, Kishan, Sahadeo, Vashaana, Kerrigan, Jason R, Park, Stephen S, Christophel, J Jared, Dighe, Abhijit S, Kumbar, Sangamesh G, Cui, Quanjun

“…Osseous craniofacial defects are currently reconstructed with bone grafting, rigid fixation, free tissue transfer, and/or recombinant human bone morphogenetic…”
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Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection by Le, Quang, Madhu, Vedavathi, Hart, Joseph M, Farber, Charles R, Zunder, Eli R, Dighe, Abhijit S, Cui, Quanjun

“…Injuries to the postnatal skeleton are naturally repaired through successive steps involving specific cell types in a process collectively termed “bone…”
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VEGF and BMP-6 enhance bone formation mediated by cloned mouse osteoprogenitor cells by Cui, Fuai, Wang, Xiuli, Liu, Xianxi, Dighe, Abhijit S., Balian, Gary, Cui, Quanjun

“…New strategies such as combined utilization of growth factors may provide a better treatment for difficult fractures. We have demonstrated enhanced…”
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Comparison of 16S rRNA gene sequences of genus Methanobrevibacter by Dighe, Abhijit S, Jangid, Kamlesh, González, José M, Pidiyar, Vyankatesh J, Patole, Milind S, Ranade, Dilip R, Shouche, Yogesh S

“…The phylogeny of the genus Methanobrevibacter was established almost 25 years ago on the basis of the similarities of the 16S rRNA oligonucleotide catalogs…”
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Osteogenic response of human adipose-derived stem cells to BMP-6, VEGF, and combined VEGF plus BMP-6 in vitro by Zhang, Yi, Madhu, Vedavathi, Dighe, Abhijit S., Irvine, James N., Cui, Quanjun

“…Exogenous addition of three factors-mesenchymal stem cells (MSCs), vascular endothelial growth factor (VEGF), and bone morphogenetic proteins (BMPs)-has proven…”
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Combined VEGF and LMP-1 delivery enhances osteoprogenitor cell differentiation and ectopic bone formation by Wang, Xiuli, Cui, Fuai, Madhu, Vedavathi, Dighe, Abhijit S., Balian, Gary, Cui, Quanjun

“…A novel strategy to enhance bone repair is to combine angiogenic factors and osteogenic factors. We combined vascular endothelial growth factor (VEGF) and LIM…”
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