Search Results - "Diggins, Nicole L"

APPL1 is a multifunctional endosomal signaling adaptor protein by Diggins, Nicole L, Webb, Donna J

“…Endosomal adaptor proteins are important regulators of signaling pathways underlying many biological processes. These adaptors can integrate signals from…”
Get more information

Advances in Model Systems for Human Cytomegalovirus Latency and Reactivation by Crawford, Lindsey B, Diggins, Nicole L, Caposio, Patrizia, Hancock, Meaghan H

“…Human cytomegalovirus (HCMV) is a highly prevalent beta-herpesvirus and a significant cause of morbidity and mortality following hematopoietic and solid organ…”
Get full text

Human Cytomegalovirus miR-US25-1 Targets the GTPase RhoA To Inhibit CD34 + Hematopoietic Progenitor Cell Proliferation To Maintain the Latent Viral Genome by Diggins, Nicole L, Crawford, Lindsey B, Hancock, Meaghan H, Mitchell, Jennifer, Nelson, Jay A

“…Human cytomegalovirus (HCMV) microRNAs play essential roles in latency and reactivation in CD34 hematopoietic progenitor cells (HPCs) via regulation of viral…”
Get full text

Proximity-dependent mapping of the HCMV US28 interactome identifies RhoGEF signaling as a requirement for efficient viral reactivation by Medica, Samuel, Crawford, Lindsey B, Denton, Michael, Min, Chan-Ki, Jones, Taylor A, Alexander, Timothy, Parkins, Christopher J, Diggins, Nicole L, Streblow, Gabriel J, Mayo, Adam T, Kreklywich, Craig N, Smith, Patricia, Jeng, Sophia, McWeeney, Shannon, Hancock, Meaghan H, Yurochko, Andrew, Cohen, Michael S, Caposio, Patrizia, Streblow, Daniel N

“…Human cytomegalovirus (HCMV) encodes multiple putative G protein-coupled receptors (GPCRs). US28 functions as a viral chemokine receptor and is expressed…”
Get full text

Regulation of Latency and Reactivation by Human Cytomegalovirus miRNAs by Diggins, Nicole L, Skalsky, Rebecca L, Hancock, Meaghan H

“…Human cytomegalovirus (HCMV) encodes 22 mature microRNAs (miRNAs), which regulate a myriad of cellular processes, including vesicular trafficking, cell cycle…”
Get full text

HCMV miRNA Targets Reveal Important Cellular Pathways for Viral Replication, Latency, and Reactivation by Diggins, Nicole L, Hancock, Meaghan H

“…It is now well appreciated that microRNAs (miRNAs) play a critical role in the lifecycles of many herpes viruses. The human cytomegalovirus (HCMV) replication…”
Get full text

Viral miRNA regulation of host gene expression by Diggins, Nicole L., Hancock, Meaghan H.

“…Viruses have evolved a multitude of mechanisms to combat barriers to productive infection in the host cell. Virally-encoded miRNAs are one such means to…”
Get full text

USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification by Nielsen, Casey P., Jernigan, Kristin K., Diggins, Nicole L., Webb, Donna J., MacGurn, Jason A.

“…The WNT signaling network is comprised of multiple receptors that relay various input signals via distinct transduction pathways to execute multiple complex…”
Get full text

α5β1 integrin trafficking and Rac activation are regulated by APPL1 in a Rab5-dependent manner to inhibit cell migration by Diggins, Nicole L, Kang, Hakmook, Weaver, Alissa, Webb, Donna J

“…Cell migration is a tightly coordinated process that requires the spatiotemporal regulation of many molecular components. Because adaptor proteins can serve as…”
Get full text

HCMV UL8 interaction with β-catenin and DVL2 regulates viral reactivation in CD34 + hematopoietic progenitor cells by Dirck, Aaron, Diggins, Nicole L, Crawford, Lindsey B, Perez, Wilma D, Parkins, Christopher J, Struthers, Hillary H, Turner, Rebekah, Pham, Andrew H, Mitchell, Jennifer, Papen, Courtney R, Malouli, Daniel, Hancock, Meaghan H, Caposio, Patrizia

“…CD34 hematopoietic progenitor cells (HPCs) are an important cellular reservoir for latent human cytomegalovirus (HCMV). Several HCMV genes are expressed during…”
Get full text

Modulation of Wnt Signaling Pathway during Cytomegalovirus Latency and Reactivation by Dirck, Aaron, Diggins, Nicole L., Caposio, Patrizia

“…Purpose of the Review The Wnt signaling pathway is one of the key pathways involved in hematopoietic progenitor cell (HPC) proliferation and differentiation…”
Get full text

Techniques for Characterizing Cytomegalovirus-Encoded miRNAs by Diggins, Nicole L, Crawford, Lindsey B, Struthers, Hillary M, Hook, Lauren M, Landais, Igor, Skalsky, Rebecca L, Hancock, Meaghan H

“…microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level by binding to sites within the 3' untranslated…”
Get more information

Automated Analysis of Cell-Matrix Adhesions in 2D and 3D Environments by Broussard, Joshua A., Diggins, Nicole L., Hummel, Stephen, Georgescu, Walter, Quaranta, Vito, Webb, Donna J.

“…Cell-matrix adhesions are of great interest because of their contribution to numerous biological processes, including cell migration, differentiation,…”
Get full text

Activation of Rac by Asef2 promotes myosin II-dependent contractility to inhibit cell migration on type I collagen by Jean, Léolène, Majumdar, Devi, Shi, Mingjian, Hinkle, Louis E, Diggins, Nicole L, Ao, Mingfang, Broussard, Joshua A, Evans, J Corey, Choma, David P, Webb, Donna J

“…Non-muscle myosin II (MyoII) contractility is central to the regulation of numerous cellular processes, including migration. Rho is a well-characterized…”
Get full text