Search Results - "Digenio, A."

ISIS-ANGPTL3RX , an antisense inhibitor to angiopoietin-like 3, reduces plasma lipid levels in mouse models and in healthy human volunteers by Brandt, T.A, Lee, R.G, Digenio, A, Graham, M.G, Crooke, R.M, Hughes, S.G, Singleton, W, Witztum, J.L, Tsimikas, S

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The APPROACH Study: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of Volanesorsen Administered Subcutaneously to Patients with Familial Chylomicronemia Syndrome (FCS) by Gaudet, D, Digenio, A, Alexander, V.J, Arca, M, Jones, A.F, Stroes, E, Bergeron, J, Civeira, F, Hemphill, L, Blom, D.J, Flaim, J, Hughes, S, Geary, R, Tsimikas, S, Witztum, J.L, Bruckert, E

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Maximizing retention in long‐term clinical trials of a weight loss agent: use of a dietitian support team by Delahanty, L. M., Riggs, M., Klioze, S. S., Chew, R. D., England, R. D., Digenio, A.

“…Summary Objective High‐attrition rates have been observed in long‐term clinical trials of weight loss agents. We evaluated the impact of an innovative…”
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Lixisenatide Reduces BeAM Value (Difference Between Bedtime (Be) and Next-Day Pre-Breakfast (AM) Glucose): A Clinical Indicator for Initiation of Prandial Therapy by Woo, Vincent, Shaefer, C, Brath, H, Digenio, A, Lin, Jay, Prasanna Kumar, K.M, Zisman, A

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Effects of Cholesteryl Ester Transfer Protein Inhibition on High-Density Lipoprotein Subspecies, Apolipoprotein A-I Metabolism, and Fecal Sterol Excretion by Brousseau, Margaret E, Diffenderfer, Margaret R, Millar, John S, Nartsupha, Chorthip, Asztalos, Bela F, Welty, Francine K, Wolfe, Megan L, Rudling, Mats, Björkhem, Ingemar, Angelin, Bo, Mancuso, James P, Digenio, Andres G, Rader, Daniel J, Schaefer, Ernst J

“…OBJECTIVE—Pharmacological inhibition of the cholesteryl ester transfer protein (CETP) in humans increases high-density lipoprotein (HDL) cholesterol (HDL-C)…”
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P297 Le lixisénatide associé à l’insuline basale diminue la variabilité glycémique chez des patients diabétiques de type 2 by Renard, E, O’Neal, D, Umpierrez, G, Digenio, A, Goldenberg, R, Hernandez-Triana, E, Lin, J, Park, C.-Y, Kovatchev, B

“…Objectif Cette analyse a évalué l’impact sur la variabilité glycémique (VGlc) du lixisénatide (LIXI) vs placebo (PBO) en association à de l’insuline basale ±…”
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Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome by Witztum, Joseph L, Gaudet, Daniel, Freedman, Steven D, Alexander, Veronica J, Digenio, Andres, Williams, Karren R, Yang, Qingqing, Hughes, Steven G, Geary, Richard S, Arca, Marcello, Stroes, Erik S.G, Bergeron, Jean, Soran, Handrean, Civeira, Fernando, Hemphill, Linda, Tsimikas, Sotirios, Blom, Dirk J, O’Dea, Louis, Bruckert, Eric

“…This phase 3 trial showed that treatment with volanesorsen, an antisense oligonucleotide drug complementary to mRNA encoding apolipoprotein C-III, resulted in…”
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Assessing the disease burden among patients with familial chylomicronemia syndrome (FCS) on volanesorsen: Results of the re-focus study by Arca, M., Soran, H., Digenio, A., Hsieh, A., Rosenblit, P., Stevenson, M.

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Effect of myocardial ischaemia on left ventricular function and adaptability to exercise training by DIGENIO, A. G, NOAKES, T. D, JOUGHIN, H, DALY, L

“…We evaluated the possible interaction between exercise-induced myocardial ischemia and abnormalities in left ventricular function in 72 patients with coronary…”
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Ventilatory responses to exercise in patients with asymptomatic left ventricular dysfunction by DIGENIO, A. G, NOAKES, T. D, JOUGHIN, H, DALY, L

“…Based on reports that patients with severe left ventricular (LV) dysfunction have a greater ventilatory response to effort than healthy people, we evaluated…”
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Physiological benefits of a prolonged moderate-intensity endurance training programme in patients with coronary artery disease by JOUGHIN, H. M, DIGENIO, A. G, DALY, L, KGARE, E

“…To assess the physiological changes that take place in patients with coronary artery disease after 6 and 18 months of moderate-intensity endurance training…”
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Evaluation of Methods for Improving Precision of Blood Pressure Measurements in Phase I Clinical Trials by Terra, Steven G., Blum, Robert A., Wei, Greg C., Lew, Robert A., Digenio, Andres G., Rajman, Iris, Kazierad, David J.

“…Small sample sizes are typically incorporated in early Phase I clinical studies, which may lead to insignificant changes in safety parameters such as blood…”
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Is severe left ventricular dysfunction a contraindication to participation in an exercise rehabilitation programme ? by DIGENIO, A. G, CANTOR, A, NOAKES, T. D, CLOETE, L, MAVUNDA, D, ESSER, J. D

“…To evaluate the effects of an exercise training programme on patients with chronic left ventricular dysfunction. Intervention, before and after the trial…”
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Left ventricular function during sepsis by Artucio, H, Digenio, A, Pereyra, M

“…The prevalence and prognostic significance of left ventricular involvement in septic patients without shock was investigated. Systolic time intervals (STI) and…”
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Exercise-related cardiac arrest in cardiac rehabilitation : the Johannesburg experience by DIGENIO, A. G, SIM, J. G. M, DOWDESWELL, R. J, MORRIS, R

“…Prescribed physical activity plays a major role in the rehabilitation of patients with coronary artery disease, and as with any other form of treatment its…”
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Multivariate models for compliance with phase 3 cardiac rehabilitation services in Johannesburg by Digenio, A G, Padayachee, N, Groeneveld, H

“…The efficacy of an exercise cardiac rehabilitation programme depends on an adequate compliance of its participants. A 50% dropout rate after 12 months has been…”
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The Johannesburg cardiac rehabilitation programme by DIGENIO, A. G, SIM, J. G. M, KRIGE, K, STEWART, A, MORRIS, R, DOWDESWELL, R. J, PADAYACHEE, G. N

“…Cardiac rehabilitation has become a generally accepted mode of treatment for patients suffering from coronary artery disease. The Johannesburg cardiac…”
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The effect of a 6-month cardiac rehabilitation programme on serum lipoproteins and apoproteins A1 and B and lipoprotein a by MORRIS, R, DIGENIO, A, PADAYACHEE, G. N, KINNEAR, B

“…One hundred and forty-two cardiac rehabilitation patients were followed up over a period of 6 months and the percentage change over time was recorded for…”
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Should all cardiac patients be offered the choice of cardiac rehabilitation? by Digenio, A G, Joughin, H M

“…To determine whether cardiac rehabilitation services are beneficial to patients and cost-effective. Several recent publications are reviewed. The first of…”
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Effects of an Inhibitor of Cholesteryl Ester Transfer Protein on HDL Cholesterol by Brousseau, Margaret E, Schaefer, Ernst J, Wolfe, Megan L, Bloedon, LeAnne T, Digenio, Andres G, Clark, Ronald W, Mancuso, James P, Rader, Daniel J

“…Low levels of high-density lipoprotein (HDL) cholesterol increase the risk of coronary heart disease. The authors of this study investigated a novel method of…”
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