Search Results - "Difrancesco, Robin"

Simultaneous determination of cortisol, dexamethasone, methylprednisolone, prednisone, prednisolone, mycophenolic acid and mycophenolic acid glucuronide in human plasma utilizing liquid chromatography–tandem mass spectrometry by DiFrancesco, Robin, Frerichs, Valerie, Donnelly, Julie, Hagler, Colleen, Hochreiter, Jill, Tornatore, Kathleen M.

“…Chronic combination immunosuppressive regimens are commonly prescribed to renal transplant recipients. To develop an assay method for pharmacokinetic studies…”
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Two decades (1998 to 2018) of collaborative human immunodeficiency virus clinical pharmacology capacity building in a resource constrained setting by Maponga, Charles C, Monera-Penduka, Tsitsi G, Mtisi, Takudzwa J, Difrancesco, Robin, Makita-Chingombe, Faithful, Mazambara, Fine, Tooley, Kathleen, Mudzviti, Tinashe, Morse, Gene D

“…While important advances have been made in the prevention and treatment of Human Immunodeficiency Virus (HIV) infection, limited expertise and resource…”
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Simultaneous analysis of cyclophosphamide, doxorubicin and doxorubicinol by liquid chromatography coupled to tandem mass spectrometry by DiFrancesco, Robin, Griggs, Jennifer J., Donnelly, Julie, DiCenzo, Robert

“…A method for the simultaneous determination of cyclophosphamide (CP), doxorubicin (dox), and doxorubicinol (dol) was developed and validated to analyze 400 μL…”
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Interaction between buprenorphine and atazanavir or atazanavir/ritonavir by McCance-Katz, Elinore F, Moody, David E, Morse, Gene D, Ma, Qing, DiFrancesco, Robin, Friedland, Gerald, Pade, Patricia, Rainey, Petrie M

“…Abstract Opioid addiction and HIV disease frequently co-occur. Adverse drug interactions have been reported between methadone and some HIV medications, but…”
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Cross-validation of a high-performance liquid chromatography nevirapine plasma assay in a resource-limited setting in Zimbabwe by Makita-Chingombe, Faithful, Podany, Anthony T., Mykris, Timothy, Muzambi, Farai, Browne, Richard W., Ocque, Andrew J., DiFrancesco, Robin, Winchester, Lee C., Fletcher, Courtney V., Mudzviti, Tinashe, Maponga, Charles C., Morse, Gene D.

“…An international HIV pharmacology specialty laboratory (PSL) was established at the University of Zimbabwe to increase bioanalytical and investigator…”
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Lipid-Lowering Therapy in HIV-Infected Patients: Relationship with Antiretroviral Agents and Impact of Substance-Related Disorders by Bednasz, Cindy, Luque, Amneris E, Zingman, Barry S, Fischl, Margaret A, Gripshover, Barbara M, Venuto, Charles S, Gu, Jie, Feng, Zekun, DiFrancesco, Robin, Morse, Gene D, Ma, Qing

“…The use of combination antiretroviral therapy (cART) has significantly decreased the morbidity and mortality associated with human immunodeficiency virus (HIV)…”
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Mycophenolic Acid Pharmacokinetics During Maintenance Immunosuppression in African American and Caucasian Renal Transplant Recipients by Tornatore, Kathleen M., Sudchada, Patcharaporn, Dole, Kiran, DiFrancesco, Robin, Leca, Nicolae, Gundroo, Aijaz C., Danison, Ryan T., Attwood, Kris, Wilding, Gregory E., Zack, Julia, Forrest, Alan, Venuto, Rocco C.

“…Renal transplant recipients exhibit variability in mycophenolic acid (MPA) and MPA glucuronide (MPAG) pharmacokinetics, which are influenced by clinical and…”
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2178 Drug development core facilitates institutional collaboration and translational science innovation by Morse, Gene, Puzanov, Igor, Gudkov, Andrei, DiFrancesco, Robin, Jusko, William, Ernstoff, Marc, Mohler, James, Murphy, Timothy, Bies, Robert

“…OBJECTIVES/SPECIFIC AIMS: Drug development is a common research pursuit for basic and clinical scientists that interfaces diagnostic/therapeutic challenges…”
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Development and validation of a high performance liquid chromatography method to determine nevirapine in plasma in a resource-limited setting by Ocque, Andrew J., Mtisi, Takudzwa J., DiFrancesco, Robin, Morse, Gene D., Maponga, Charles, Muzambi, Farai, Makita-Chingombe, Faithful, Monera-Penduka, Tsitsi G., Mudzviti, Tinashe

“…Background: There are several instances where nevirapine pharmacokinetic monitoring may be useful, such as in special populations or pharmacokinetic drug…”
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Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients by Ma, Qing, Gelbard, Harris A., Maggirwar, Sanjay B., Dewhurst, Stephen, Gendelman, Howard E., Peterson, Derick R., DiFrancesco, Robin, Hochreiter, Jill S., Morse, Gene D., Schifitto, Giovanni

“…CEP-1347 is a potent inhibitor of mixed lineage kinase (MLK), which was investigated for ameliorating HIV-associated neurocognitive disorders. CEP-1347 and…”
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Inhibition of Atazanavir Oral Absorption by Lansoprazole Gastric Acid Suppression in Healthy Volunteers by Tomilo, Desiree L., Smith, Patrick F., Ogundele, Abayomi B., Difrancesco, Robin, Berenson, Charles S., Eberhardt, Ellana, Bednarczyk, Edward, Morse, Gene D.

“…Study Objective. To determine whether the pharmacokinetics of atazanavir, a protease inhibitor used to treat human immunodeficiency virus (HIV) infection, are…”
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Quality Assurance Program for Clinical Measurement of Antiretrovirals: AIDS Clinical Trials Group Proficiency Testing Program for Pediatric and Adult Pharmacology Laboratories by HOLLAND, Diane T, DIFRANCESCO, Robin, STONE, Judith, HAMZEH, Fayez, CONNOR, James D, MORSE, Gene D

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Determination of protease inhibitors using liquid chromatography–tandem mass spectrometry by Frerichs, Valerie A, DiFrancesco, Robin, Morse, Gene D

“…A method for the analysis of six protease inhibitors and one metabolite has been developed and validated. Amprenavir, ritonavir, saquinavir, lopinavir,…”
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Compartmental Pharmacokinetic Analysis of Oral Amprenavir with Secondary Peaks by OKUSANYA, Olanrewaju, FORREST, Alan, DIFRANCESCO, Robin, BILIC, Sanela, ROSENKRANZ, Susan, PARA, Michael F, ADAMS, Elizabeth, YARASHESKI, Kevin E, REICHMAN, Richard C, MORSE, Gene D

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Reverse phase high-performance liquid chromatography method for the analysis of amprenavir, efavirenz, indinavir, lopinavir, nelfinavir and its active metabolite (M8), ritonavir, and saquinavir in heparinized human plasma by KEIL, Kim, FRERICHS, Valerie A, DIFRANCESCO, Robin, MORSE, Gene

“…The increasing interest in applying therapeutic drug monitoring (TDM) to antiretroviral therapy is related to the observed interindividual variation in…”
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Amprenavir and Efavirenz Pharmacokinetics before and after the Addition of Nelfinavir, Indinavir, Ritonavir, or Saquinavir in Seronegative Individuals by MORSE, Gene D, ROSENKRANZ, Susan, PARA, Michael F, SEGAL, Yoninah, DIFRANCESCO, Robin, ADAMS, Elizabeth, BRIZZ, Barbara, YARASHESKI, Kevin E, REICHMAN, Richard C

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The Effects of Once-Daily Saquinavir/Minidose Ritonavir on the Pharmacokinetics of Methadone by Shelton, Mark J., Cloen, Denise, DiFrancesco, Robin, Berenson, Charles S., Esch, Andrew, de Caprariis, Pascal J., Palic, Branka, Schur, Jane L., Buggé, Christopher J. L., Ljungqvist, Anders, Espinosa, Orlando, Hewitt, Ross G.

“…Twelve methadone‐maintained HIV‐negative subjects were given saquinavir/ritonavir (SQV/rtv) 1600 mg/100 mg once daily for 14 days. Pharmacokinetic evaluations…”
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Effects of Grapefruit Juice on Pharmacokinetic Exposure to Indinavir in HIV-Positive Subjects by Shelton, Mark J., Wynn, Heather E., Hewitt, Ross G., DiFrancesco, Robin

“…The objective of this study was to determine the effects of double‐strength grapefruit juice on gastric pH and systemic bioavailability of indinavir in…”
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Development and validation of an assay to measure cannabidiol and Δ9-tetrahydrocannabinol in human EDTA plasma by UHPLC-MS/MS by Ocque, Andrew J., Hagler, Colleen E., DiFrancesco, Robin, Lombardo, Jeffrey, Morse, Gene D.

“…The therapeutic use of cannabinoids has increased with providers often recommending cannabinoid-containing products with limited pre-clinical and clinical…”
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Ultra-performance liquid chromatography tandem mass spectrometry for determination of Direct Acting Antiviral drugs in human liver fine needle aspirates by Ocque, Andrew J., Hagler, Colleen E., DiFrancesco, Robin, Morse, Gene D., Talal, Andrew H.

“…•UPLC–MS/MS method for measurement of DSV, DSVm1, OBV, PTV, and RTV in human liver FNA.•The method is validated with high accuracy and precision.•The method is…”
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