Search Results - "Diffenderfer, Eric S"

Predicting radiation pneumonitis in locally advanced stage II–III non-small cell lung cancer using machine learning by Luna, José Marcio, Chao, Hann-Hsiang, Diffenderfer, Eric S., Valdes, Gilmer, Chinniah, Chidambaram, Ma, Grace, Cengel, Keith A., Solberg, Timothy D., Berman, Abigail T., Simone, Charles B.

“…•Among an extensive set of 32 clinical and dosimetric features, Lung V20, mean lung dose, lung V10 and lung V5 are the best individual predictors of radiation…”
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Patient-derived organoids as a platform for modeling a patient’s response to chemoradiotherapy in esophageal cancer by Karakasheva, Tatiana A., Gabre, Joel T., Sachdeva, Uma M., Cruz-Acuña, Ricardo, Lin, Eric W., DeMarshall, Maureen, Falk, Gary W., Ginsberg, Gregory G., Yang, Zhaohai, Kim, Michele M., Diffenderfer, Eric S., Pitarresi, Jason R., Li, Jinyang, Muir, Amanda B., Hamilton, Kathryn E., Nakagawa, Hiroshi, Bass, Adam J., Rustgi, Anil K.

“…3D patient-derived organoids (PDOs) have been utilized to evaluate potential therapies for patients with different cancers. However, the use of PDOs created…”
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Linear Energy Transfer Painting With Proton Therapy: A Means of Reducing Radiation Doses With Equivalent Clinical Effectiveness by Fager, Marcus, MSc, Toma-Dasu, Iuliana, PhD, Kirk, Maura, MSc, Dolney, Derek, PhD, Diffenderfer, Eric S., PhD, Vapiwala, Neha, MD, Carabe, Alejandro, PhD

“…Purpose The purpose of this study was to propose a proton treatment planning method that trades physical dose (D) for dose-averaged linear energy transfer…”
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A phenomenological model of proton FLASH oxygen depletion effects depending on tissue vasculature and oxygen supply by Zou, Wei, Kim, Haram, Diffenderfer, Eric S, Carlson, David J, Koch, Cameron J, Xiao, Ying, Teo, BoonKeng K, Kim, Michele M, Metz, James M, Fan, Yi, Maity, Amit, Koumenis, Costas, Busch, Theresa M, Wiersma, Rodney, Cengel, Keith A, Dong, Lei

“…Radiation-induced oxygen depletion in tissue is assumed as a contributor to the FLASH sparing effects. In this study, we simulated the heterogeneous oxygen…”
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Effect of solar particle event radiation and hindlimb suspension on gastrointestinal tract bacterial translocation and immune activation by Zhou, Yu, Ni, Houping, Li, Minghong, Sanzari, Jenine K, Diffenderfer, Eric S, Lin, Liyong, Kennedy, Ann R, Weissman, Drew

“…The environmental conditions that could lead to an increased risk for the development of an infection during prolonged space flight include: microgravity,…”
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Leukocyte activity is altered in a ground based murine model of microgravity and proton radiation exposure by Sanzari, Jenine K, Romero-Weaver, Ana L, James, Gabrielle, Krigsfeld, Gabriel, Lin, Liyong, Diffenderfer, Eric S, Kennedy, Ann R

“…Immune system adaptation during spaceflight is a concern in space medicine. Decreased circulating leukocytes observed during and after space flight infer…”
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Broad-spectrum antibiotic or G-CSF as potential countermeasures for impaired control of bacterial infection associated with an SPE exposure during spaceflight by Li, Minghong, Holmes, Veronica, Ni, Houping, Sanzari, Jenine K, Romero-Weaver, Ana L, Lin, Liyong, Carabe-Fernandez, Alejandro, Diffenderfer, Eric S, Kennedy, Ann R, Weissman, Drew

“…A major risk for astronauts during prolonged space flight is infection as a result of the combined effects of microgravity, situational and confinement stress,…”
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Ionizing radiation selectively reduces skin regulatory T cells and alters immune function by Zhou, Yu, Ni, Houping, Balint, Klara, Sanzari, Jenine K, Dentchev, Tzvete, Diffenderfer, Eric S, Wilson, Jolaine M, Cengel, Keith A, Weissman, Drew

“…The skin serves multiple functions that are critical for life. The protection from pathogens is achieved by a complicated interaction between aggressive…”
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The current status of preclinical proton FLASH radiation and future directions by Diffenderfer, Eric S., Sørensen, Brita S., Mazal, Alejandro, Carlson, David J.

“…We review the current status of proton FLASH experimental systems, including preclinical physical and biological results. Technological limitations on…”
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Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System by Diffenderfer, Eric S., Verginadis, Ioannis I., Kim, Michele M., Shoniyozov, Khayrullo, Velalopoulou, Anastasia, Goia, Denisa, Putt, Mary, Hagan, Sarah, Avery, Stephen, Teo, Kevin, Zou, Wei, Lin, Alexander, Swisher-McClure, Samuel, Koch, Cameron, Kennedy, Ann R., Minn, Andy, Maity, Amit, Busch, Theresa M., Dong, Lei, Koumenis, Costas, Metz, James, Cengel, Keith A.

“…Recent studies suggest that ultrahigh-dose-rate, “FLASH,” electron radiation therapy (RT) decreases normal tissue damage while maintaining tumor response…”
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Machine learning highlights the deficiency of conventional dosimetric constraints for prevention of high-grade radiation esophagitis in non-small cell lung cancer treated with chemoradiation by Luna, José Marcio, Chao, Hann-Hsiang, Shinohara, Russel T., Ungar, Lyle H., Cengel, Keith A., Pryma, Daniel A., Chinniah, Chidambaram, Berman, Abigail T., Katz, Sharyn I., Kontos, Despina, Simone, Charles B., Diffenderfer, Eric S.

“…•A large cohort to predict radiation esophagitis in lung cancer patients was used.•Modern machine learning models were implemented to predict radiation…”
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Building more accurate decision trees with the additive tree by Luna, José Marcio, Gennatas, Efstathios D., Ungar, Lyle H., Eaton, Eric, Diffenderfer, Eric S., Jensen, Shane T., Simone, Charles B., Friedman, Jerome H., Solberg, Timothy D., Valdes, Gilmer

“…The expansion of machine learning to high-stakes application domains such as medicine, finance, and criminal justice, where making informed decisions requires…”
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Relative biological effectiveness of simulated solar particle event proton radiation to induce acute hematological change in the porcine model by Sanzari, Jenine K., Wan, Steven X., Diffenderfer, Eric S., Cengel, Keith A., Kennedy, Ann R.

“…The present study was undertaken to determine relative biological effectiveness (RBE) values for simulated solar particle event (SPE) radiation on peripheral…”
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FLASH Radiotherapy: What Can FLASH's Ultra High Dose Rate Offer to the Treatment of Patients With Sarcoma? by Cengel, Keith A., Kim, Michele M., Diffenderfer, Eric S., Busch, Theresa M.

“…FLASH is an emerging treatment paradigm in radiotherapy (RT) that utilizes ultra-high dose rates (UHDR; >40 Gy)/s) of radiation delivery. Developing advances…”
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Monte Carlo modeling in CT-based geometries: dosimetry for biological modeling experiments with particle beam radiation by Diffenderfer, Eric S., Dolney, Derek, Schaettler, Maximilian, Sanzari, Jenine K., Mcdonough, James, Cengel, Keith A.

“…The space radiation environment imposes increased dangers of exposure to ionizing radiation, particularly during a solar particle event (SPE). These events…”
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Current delivery limitations of proton PBS for FLASH by Zou, Wei, Diffenderfer, Eric S., Cengel, Keith A., Kim, Michele M., Avery, Steve, Konzer, Joshua, Cai, Yongliang, Boisseu, Paul, Ota, Kan, Yin, Lingshu, Wiersma, Rodney, Carlson, David J., Fan, Yi, Busch, Theresa M., Koumenis, Costas, Lin, Alexander, Metz, James M., Teo, BoonKeng K., Dong, Lei

“…•FLASH proton PBS has strong potential to be implemented for patient treatment.•Clinical proton PBS delivery parameters were extrapolated to high cyclotron…”
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FLASH Proton Radiation Therapy Mitigates Inflammatory and Fibrotic Pathways and Preserves Cardiac Function in a Preclinical Mouse Model of Radiation-Induced Heart Disease by Kim, Kyle, Kim, Michele M., Skoufos, Giorgos, Diffenderfer, Eric S., Motlagh, Seyyedeh Azar Oliaei, Kokkorakis, Michail, Koliaki, Ilektra, Morcos, George, Shoniyozov, Khayrullo, Griffin, Joanna, Hatzigeorgiou, Artemis G., Metz, James M., Lin, Alexander, Feigenberg, Steven J., Cengel, Keith A., Ky, Bonnie, Koumenis, Constantinos, Verginadis, Ioannis I.

“…Studies during the past 9 years suggest that delivering radiation at dose rates exceeding 40 Gy/s, known as “FLASH” radiation therapy, enhances the therapeutic…”
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Proton radiation boosts the efficacy of mesothelin-targeting chimeric antigen receptor T cell therapy in pancreatic cancer by Amit, Uri, Uslu, Ugur, Verginadis, Ioannis I, Kim, Michele M, Motlagh, Seyyedeh Azar Oliaei, Diffenderfer, Eric S, Assenmacher, Charles-Antoine, Bicher, Sandra, Atoche, Sebastian J, Ben-Josef, Edgar, Young, Regina M, June, Carl H, Koumenis, Constantinos

“…Pancreatic ductal adenocarcinoma (PDAC) represents a challenge in oncology, with limited treatment options for advanced-stage patients. Chimeric antigen…”
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Design and commissioning of an image-guided small animal radiation platform and quality assurance protocol for integrated proton and x-ray radiobiology research by Kim, Michele M, Irmen, Peyton, Shoniyozov, Khayrullo, Verginadis, Ioannis I, Cengel, Keith A, Koumenis, Costantinos, Metz, James M, Dong, Lei, Diffenderfer, Eric S

“…Small animal x-ray irradiation platforms are expanding the capabilities and future pathways for radiobiology research. Meanwhile, proton radiotherapy is…”
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Framework for Quality Assurance of Ultrahigh Dose Rate Clinical Trials Investigating FLASH Effects and Current Technology Gaps by Zou, Wei, Zhang, Rongxiao, Schüler, Emil, Taylor, Paige A., Mascia, Anthony E., Diffenderfer, Eric S., Zhao, Tianyu, Ayan, Ahmet S., Sharma, Manju, Yu, Shu-Jung, Lu, Weiguo, Bosch, Walter R., Tsien, Christina, Surucu, Murat, Pollard-Larkin, Julianne M., Schuemann, Jan, Moros, Eduardo G., Bazalova-Carter, Magdalena, Gladstone, David J., Li, Heng, Simone, Charles B., Petersson, Kristoffer, Kry, Stephen F., Maity, Amit, Loo, Billy W., Dong, Lei, Maxim, Peter G., Xiao, Ying, Buchsbaum, Jeffrey C.

“…FLASH radiation therapy (FLASH-RT), delivered with ultrahigh dose rate (UHDR), may allow patients to be treated with less normal tissue toxicity for a given…”
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