Search Results - "Diffenderfer, Eric"

The current status of preclinical proton FLASH radiation and future directions by Diffenderfer, Eric S., Sørensen, Brita S., Mazal, Alejandro, Carlson, David J.

“…We review the current status of proton FLASH experimental systems, including preclinical physical and biological results. Technological limitations on…”
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Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System by Diffenderfer, Eric S., Verginadis, Ioannis I., Kim, Michele M., Shoniyozov, Khayrullo, Velalopoulou, Anastasia, Goia, Denisa, Putt, Mary, Hagan, Sarah, Avery, Stephen, Teo, Kevin, Zou, Wei, Lin, Alexander, Swisher-McClure, Samuel, Koch, Cameron, Kennedy, Ann R., Minn, Andy, Maity, Amit, Busch, Theresa M., Dong, Lei, Koumenis, Costas, Metz, James, Cengel, Keith A.

“…Recent studies suggest that ultrahigh-dose-rate, “FLASH,” electron radiation therapy (RT) decreases normal tissue damage while maintaining tumor response…”
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Ultrafast Tracking of Oxygen Dynamics During Proton FLASH by El Khatib, Mirna, Van Slyke, Alexander L., Velalopoulou, Anastasia, Kim, Michele M., Shoniyozov, Khayrullo, Allu, Srinivasa Rao, Diffenderfer, Eric S., Busch, Theresa M., Wiersma, Rodney D., Koch, Cameron J., Vinogradov, Sergei A.

“…Radiation therapy delivered at ultrafast dose rates, known as FLASH RT, has been shown to provide a therapeutic advantage compared with conventional radiation…”
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Predicting radiation pneumonitis in locally advanced stage II–III non-small cell lung cancer using machine learning by Luna, José Marcio, Chao, Hann-Hsiang, Diffenderfer, Eric S., Valdes, Gilmer, Chinniah, Chidambaram, Ma, Grace, Cengel, Keith A., Solberg, Timothy D., Berman, Abigail T., Simone, Charles B.

“…•Among an extensive set of 32 clinical and dosimetric features, Lung V20, mean lung dose, lung V10 and lung V5 are the best individual predictors of radiation…”
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Building more accurate decision trees with the additive tree by Luna, José Marcio, Gennatas, Efstathios D., Ungar, Lyle H., Eaton, Eric, Diffenderfer, Eric S., Jensen, Shane T., Simone, Charles B., Friedman, Jerome H., Solberg, Timothy D., Valdes, Gilmer

“…The expansion of machine learning to high-stakes application domains such as medicine, finance, and criminal justice, where making informed decisions requires…”
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FLASH Radiotherapy: What Can FLASH's Ultra High Dose Rate Offer to the Treatment of Patients With Sarcoma? by Cengel, Keith A., Kim, Michele M., Diffenderfer, Eric S., Busch, Theresa M.

“…FLASH is an emerging treatment paradigm in radiotherapy (RT) that utilizes ultra-high dose rates (UHDR; >40 Gy)/s) of radiation delivery. Developing advances…”
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Linear Energy Transfer Painting With Proton Therapy: A Means of Reducing Radiation Doses With Equivalent Clinical Effectiveness by Fager, Marcus, MSc, Toma-Dasu, Iuliana, PhD, Kirk, Maura, MSc, Dolney, Derek, PhD, Diffenderfer, Eric S., PhD, Vapiwala, Neha, MD, Carabe, Alejandro, PhD

“…Purpose The purpose of this study was to propose a proton treatment planning method that trades physical dose (D) for dose-averaged linear energy transfer…”
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Current delivery limitations of proton PBS for FLASH by Zou, Wei, Diffenderfer, Eric S., Cengel, Keith A., Kim, Michele M., Avery, Steve, Konzer, Joshua, Cai, Yongliang, Boisseu, Paul, Ota, Kan, Yin, Lingshu, Wiersma, Rodney, Carlson, David J., Fan, Yi, Busch, Theresa M., Koumenis, Costas, Lin, Alexander, Metz, James M., Teo, BoonKeng K., Dong, Lei

“…•FLASH proton PBS has strong potential to be implemented for patient treatment.•Clinical proton PBS delivery parameters were extrapolated to high cyclotron…”
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Patient-derived organoids as a platform for modeling a patient’s response to chemoradiotherapy in esophageal cancer by Karakasheva, Tatiana A., Gabre, Joel T., Sachdeva, Uma M., Cruz-Acuña, Ricardo, Lin, Eric W., DeMarshall, Maureen, Falk, Gary W., Ginsberg, Gregory G., Yang, Zhaohai, Kim, Michele M., Diffenderfer, Eric S., Pitarresi, Jason R., Li, Jinyang, Muir, Amanda B., Hamilton, Kathryn E., Nakagawa, Hiroshi, Bass, Adam J., Rustgi, Anil K.

“…3D patient-derived organoids (PDOs) have been utilized to evaluate potential therapies for patients with different cancers. However, the use of PDOs created…”
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FLASH Proton Radiation Therapy Mitigates Inflammatory and Fibrotic Pathways and Preserves Cardiac Function in a Preclinical Mouse Model of Radiation-Induced Heart Disease by Kim, Kyle, Kim, Michele M., Skoufos, Giorgos, Diffenderfer, Eric S., Motlagh, Seyyedeh Azar Oliaei, Kokkorakis, Michail, Koliaki, Ilektra, Morcos, George, Shoniyozov, Khayrullo, Griffin, Joanna, Hatzigeorgiou, Artemis G., Metz, James M., Lin, Alexander, Feigenberg, Steven J., Cengel, Keith A., Ky, Bonnie, Koumenis, Constantinos, Verginadis, Ioannis I.

“…Studies during the past 9 years suggest that delivering radiation at dose rates exceeding 40 Gy/s, known as “FLASH” radiation therapy, enhances the therapeutic…”
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Proton radiation boosts the efficacy of mesothelin-targeting chimeric antigen receptor T cell therapy in pancreatic cancer by Amit, Uri, Uslu, Ugur, Verginadis, Ioannis I, Kim, Michele M, Motlagh, Seyyedeh Azar Oliaei, Diffenderfer, Eric S, Assenmacher, Charles-Antoine, Bicher, Sandra, Atoche, Sebastian J, Ben-Josef, Edgar, Young, Regina M, June, Carl H, Koumenis, Constantinos

“…Pancreatic ductal adenocarcinoma (PDAC) represents a challenge in oncology, with limited treatment options for advanced-stage patients. Chimeric antigen…”
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Design and commissioning of an image-guided small animal radiation platform and quality assurance protocol for integrated proton and x-ray radiobiology research by Kim, Michele M, Irmen, Peyton, Shoniyozov, Khayrullo, Verginadis, Ioannis I, Cengel, Keith A, Koumenis, Costantinos, Metz, James M, Dong, Lei, Diffenderfer, Eric S

“…Small animal x-ray irradiation platforms are expanding the capabilities and future pathways for radiobiology research. Meanwhile, proton radiotherapy is…”
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Framework for Quality Assurance of Ultrahigh Dose Rate Clinical Trials Investigating FLASH Effects and Current Technology Gaps by Zou, Wei, Zhang, Rongxiao, Schüler, Emil, Taylor, Paige A., Mascia, Anthony E., Diffenderfer, Eric S., Zhao, Tianyu, Ayan, Ahmet S., Sharma, Manju, Yu, Shu-Jung, Lu, Weiguo, Bosch, Walter R., Tsien, Christina, Surucu, Murat, Pollard-Larkin, Julianne M., Schuemann, Jan, Moros, Eduardo G., Bazalova-Carter, Magdalena, Gladstone, David J., Li, Heng, Simone, Charles B., Petersson, Kristoffer, Kry, Stephen F., Maity, Amit, Loo, Billy W., Dong, Lei, Maxim, Peter G., Xiao, Ying, Buchsbaum, Jeffrey C.

“…FLASH radiation therapy (FLASH-RT), delivered with ultrahigh dose rate (UHDR), may allow patients to be treated with less normal tissue toxicity for a given…”
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Dose to Highly Functional Ventilation Zones Improves Prediction of Radiation Pneumonitis for Proton and Photon Lung Cancer Radiation Therapy by O’Reilly, Shannon, Jain, Varsha, Huang, Qijie, Cheng, Chingyun, Teo, Boon-Keng Kevin, Yin, Lingshu, Zhang, Miao, Diffenderfer, Eric, Li, Taoran, Levin, William, Xiao, Ying, Dong, Lei, Feigenberg, Steven, Berman, Abigail T., Zou, Wei

“…We hypothesized that the radiation dose in high-ventilation portions of the lung better predicts radiation pneumonitis (RP) outcome for patients treated with…”
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Effect of solar particle event radiation and hindlimb suspension on gastrointestinal tract bacterial translocation and immune activation by Zhou, Yu, Ni, Houping, Li, Minghong, Sanzari, Jenine K, Diffenderfer, Eric S, Lin, Liyong, Kennedy, Ann R, Weissman, Drew

“…The environmental conditions that could lead to an increased risk for the development of an infection during prolonged space flight include: microgravity,…”
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Characterization of a high‐resolution 2D transmission ion chamber for independent validation of proton pencil beam scanning of conventional and FLASH dose delivery by Zou, Wei, Diffenderfer, Eric S., Ota, Kan, Boisseau, Paul, Kim, Michele M., Cai, Yongliang, Avery, Stephen M., Carlson, David J., Wiersma, Rodney D., Lin, Alexander, Koumenis, Constantinos, Cengel, Keith A., Metz, James M., Dong, Lei, Teo, Boonkeng K.

“…Introduction Ultra‐high dose rate (FLASH) radiotherapy has become a popular research topic with the potential to reduce normal tissue toxicities without losing…”
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Leukocyte activity is altered in a ground based murine model of microgravity and proton radiation exposure by Sanzari, Jenine K, Romero-Weaver, Ana L, James, Gabrielle, Krigsfeld, Gabriel, Lin, Liyong, Diffenderfer, Eric S, Kennedy, Ann R

“…Immune system adaptation during spaceflight is a concern in space medicine. Decreased circulating leukocytes observed during and after space flight infer…”
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Radiomic Phenotypes for Improving Early Prediction of Survival in Stage III Non-Small Cell Lung Cancer Adenocarcinoma after Chemoradiation by Luna, José Marcio, Barsky, Andrew R, Shinohara, Russell T, Roshkovan, Leonid, Hershman, Michelle, Dreyfuss, Alexandra D, Horng, Hannah, Lou, Carolyn, Noël, Peter B, Cengel, Keith A, Katz, Sharyn, Diffenderfer, Eric S, Kontos, Despina

“…We evaluate radiomic phenotypes derived from CT scans as early predictors of overall survival (OS) after chemoradiation in stage III primary lung…”
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Broad-spectrum antibiotic or G-CSF as potential countermeasures for impaired control of bacterial infection associated with an SPE exposure during spaceflight by Li, Minghong, Holmes, Veronica, Ni, Houping, Sanzari, Jenine K, Romero-Weaver, Ana L, Lin, Liyong, Carabe-Fernandez, Alejandro, Diffenderfer, Eric S, Kennedy, Ann R, Weissman, Drew

“…A major risk for astronauts during prolonged space flight is infection as a result of the combined effects of microgravity, situational and confinement stress,…”
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A phenomenological model of proton FLASH oxygen depletion effects depending on tissue vasculature and oxygen supply by Zou, Wei, Kim, Haram, Diffenderfer, Eric S, Carlson, David J, Koch, Cameron J, Xiao, Ying, Teo, BoonKeng K, Kim, Michele M, Metz, James M, Fan, Yi, Maity, Amit, Koumenis, Costas, Busch, Theresa M, Wiersma, Rodney, Cengel, Keith A, Dong, Lei

“…Radiation-induced oxygen depletion in tissue is assumed as a contributor to the FLASH sparing effects. In this study, we simulated the heterogeneous oxygen…”
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