Search Results - "Dietsch, Charles R"

Design, Synthesis, and Biological Evaluation of Matrix Metalloproteinase Inhibitors Derived from a Modified Proline Scaffold by Cheng, Menyan, De, Biswanath, Almstead, Neil G, Pikul, Stanislaw, Dowty, Martin E, Dietsch, Charles R, Dunaway, C. Michelle, Gu, Fei, Hsieh, Lily C, Janusz, Michael J, Taiwo, Yetunde O, Natchus, Michael G, Hudlicky, Tomas, Mandel, Martin

“…The synthesis and structure−activity relationship (SAR) studies of a series of proline-based matrix metalloproteinase inhibitors are described. The data reveal…”
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Development of New Hydroxamate Matrix Metalloproteinase Inhibitors Derived from Functionalized 4-Aminoprolines by Natchus, Michael G, Bookland, Roger G, De, Biswanath, Almstead, Neil G, Pikul, Stanislaw, Janusz, Michael J, Heitmeyer, Sandra A, Hookfin, Erin B, Hsieh, Lily C, Dowty, Martin E, Dietsch, Charles R, Patel, Vikram S, Garver, Susan M, Gu, Fei, Pokross, Matthew E, Mieling, Glen E, Baker, Timothy R, Foltz, David J, Peng, Sean X, Bornes, David M, Strojnowski, Michael J, Taiwo, Yetunde O

“…A series of hydroxamates was prepared from an aminoproline scaffold and tested for efficacy as matrix metalloproteinase (MMP) inhibitors. Detailed SAR for the…”
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Improved prediction of in vivo peroral absorption from in vitro intestinal permeability using an internal standard to control for intra- and inter-rat variability by DOWTY, M. E, DIETSCH, C. R

“…To evaluate the use of an in vitro intestinal permeability model to predict rat and human absorption as well as to evaluate the use of an internal standard to…”
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