Search Results - "Dietrich, Pierre‐Yves"

The probabilistic model of Alzheimer disease: the amyloid hypothesis revised by Frisoni, Giovanni B., Altomare, Daniele, Thal, Dietmar Rudolf, Ribaldi, Federica, van der Kant, Rik, Ossenkoppele, Rik, Blennow, Kaj, Cummings, Jeffrey, van Duijn, Cornelia, Nilsson, Peter M., Dietrich, Pierre-Yves, Scheltens, Philip, Dubois, Bruno

“…The current conceptualization of Alzheimer disease (AD) is driven by the amyloid hypothesis, in which a deterministic chain of events leads from amyloid…”
Get full text

CAR T-Cell Therapies in Glioblastoma: A First Look by Migliorini, Denis, Dietrich, Pierre-Yves, Stupp, Roger, Linette, Gerald P, Posey, Jr, Avery D, June, Carl H

“…Glioblastoma is an aggressive malignancy with a poor prognosis. The current standard of care for newly diagnosed glioblastoma patients includes surgery to the…”
Get full text

Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma by Cosset, Érika, Ilmjärv, Sten, Dutoit, Valérie, Elliott, Kathryn, von Schalscha, Tami, Camargo, Maria F., Reiss, Alexander, Moroishi, Toshiro, Seguin, Laetitia, Gomez, German, Moo, Jung-Soon, Preynat-Seauve, Olivier, Krause, Karl-Heinz, Chneiweiss, Hervé, Sarkaria, Jann N., Guan, Kun-Liang, Dietrich, Pierre-Yves, Weis, Sara M., Mischel, Paul S., Cheresh, David A.

“…While molecular subtypes of glioblastoma (GBM) are defined using gene expression and mutation profiles, we identify a unique subpopulation based on addiction…”
Get full text

Clonal expansion of intra-epithelial T cells in breast cancer revealed by spatial transcriptomics by Romanens, Lou, Chaskar, Prasad, Marcone, Rachel, Ryser, Stephan, Tille, Jean-Christophe, Genolet, Raphael, Heimgartner-Hu, Ketty, Heimgartner, Killian, Moore, Jonathan S, Liaudet, Nicolas, Kaya, Gürkan, Pittet, Mikael J, Dietrich, Pierre-Yves, Delorenzi, Mauro, Speiser, Daniel E, Harari, Alexandre, Tsantoulis, Petros, Labidi-Galy, Sana Intidhar

“…The spatial distribution of tumor-infiltrating lymphocytes (TIL) predicts breast cancer outcome and response to systemic therapy, highlighting the importance…”
Get full text

Responsiveness to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade in SB28 and GL261 mouse glioma models by Genoud, Vassilis, Marinari, Eliana, Nikolaev, Sergey I, Castle, John C, Bukur, Valesca, Dietrich, Pierre-Yves, Okada, Hideho, Walker, Paul R

“…Immune checkpoint blockade (ICB) is currently evaluated in patients with glioblastoma (GBM), based on encouraging clinical data in other cancers, and results…”
Get full text

Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients by Migliorini, Denis, Dutoit, Valérie, Allard, Mathilde, Grandjean Hallez, Nicole, Marinari, Eliana, Widmer, Valérie, Philippin, Géraldine, Corlazzoli, Francesca, Gustave, Robin, Kreutzfeldt, Mario, Blazek, Nathalie, Wasem, Joëlle, Hottinger, Andreas, Koka, Avinash, Momjian, Shahan, Lobrinus, Alexander, Merkler, Doron, Vargas, Maria-Isabel, Walker, Paul R, Patrikidou, Anna, Dietrich, Pierre-Yves

“…Abstract Background Peptide vaccines offer the opportunity to elicit glioma-specific T cells with tumor killing ability. Using antigens eluted from the surface…”
Get full text

Prevention of CNS relapse in diffuse large B-cell lymphoma by Kridel, Robert, MD, Dietrich, Pierre-Yves, Prof

“…Summary CNS relapse occurs in about 5% of patients during the course of diffuse large B-cell lymphoma and entails a dismal prognosis. This consideration has…”
Get full text

Immune Checkpoint Inhibitor-Associated Myocarditis: A New Challenge for Cardiologists by Frigeri, Mauro, Meyer, Philippe, Banfi, Carlo, Giraud, Raphaël, Hachulla, Anne-Lise, Spoerl, David, Friedlaender, Alex, Pugliesi-Rinaldi, Angela, Dietrich, Pierre-Yves

“…The ever-increasing use of immune checkpoint inhibitors in cancer is leading to a high incidence of autoimmune side effects. This report discusses an…”
Get full text

Patients' experiences with cancer care in Switzerland: Results of a multicentre cross‐sectional survey by Arditi, Chantal, Eicher, Manuela, Colomer‐Lahiguera, Sara, Bienvenu, Christine, Anchisi, Sandro, Betticher, Daniel, Dietrich, Pierre‐Yves, Duchosal, Michel, Peters, Solange, Peytremann‐Bridevaux, Isabelle

“…Objectives The objectives were to describe patients' experiences of cancer care in Switzerland and explore the variation of these experiences by type of…”
Get full text

Linking unfolded protein response to ovarian cancer cell fusion by Yart, Lucile, Bastida-Ruiz, Daniel, Allard, Mathilde, Dietrich, Pierre-Yves, Petignat, Patrick, Cohen, Marie

“…Polyploid giant cancer cells (PGCCs) have been observed in epithelial ovarian tumors. They can resist antimitotic drugs, thus participating in tumor…”
Get full text

Long-Term Follow-Up of Patients With Follicular Lymphoma Receiving Single-Agent Rituximab at Two Different Schedules in Trial SAKK 35/98 by MARTINELLI, Giovanni, HSU SCHMITZ, Shu-Fang, VOROBIOF, Daniel, LOHRI, Andreas, DIETRICH, Pierre-Yves, ZUCCA, Emanuele, GHIELMINI, Michele, UTIGER, Urs, CERNY, Thomas, HESS, Urs, BASSI, Simona, OKKINGA, Emmie, STUPP, Roger, STAHEL, Rolf, HEIZMANN, Marc

“…We report the long-term results of a randomized clinical trial comparing induction therapy with once per week for 4 weeks single-agent rituximab alone versus…”
Get full text

Phase I/IIa Study of Cilengitide and Temozolomide With Concomitant Radiotherapy Followed by Cilengitide and Temozolomide Maintenance Therapy in Patients With Newly Diagnosed Glioblastoma by STUPP, Roger, HEGI, Monika E, PIETSCH, Torsten, HICKING, Christine, TONN, Joerg-Christian, DISERENS, Annie-Claire, PICA, Alessia, HERMISSON, Mirjam, KRUEGER, Stefan, PICARD, Martin, WELLER, Michael, NEYNS, Bart, GOLDBRUNNER, Roland, SCHLEGEL, Uwe, CLEMENT, Paul M. J, GRABENBAUER, Gerhard G, OCHSENBEIN, Adrian F, SIMON, Matthias, DIETRICH, Pierre-Yves

“…Invasion and migration are key processes of glioblastoma and are tightly linked to tumor recurrence. Integrin inhibition using cilengitide has shown synergy…”
Get full text

Stem Cell–Related “Self-Renewal” Signature and High Epidermal Growth Factor Receptor Expression Associated With Resistance to Concomitant Chemoradiotherapy in Glioblastoma by MURAT, Anastasia, MIGLIAVACCA, Eugenia, HAINFELLNER, Johannes A, HEPPNER, Frank L, DIETRICH, Pierre-Yves, ZIMMER, Yitzhak, CAIRNCROSS, J. Gregory, JANZER, Robert-Charles, DOMANY, Eytan, DELORENZI, Mauro, STUPP, Roger, HEGI, Monika E, GORLIA, Thierry, LAMBIV, Wanyu L, SHAY, Tal, HAMOU, Marie-France, DE TRIBOLET, Nicolas, REGLI, Luca, WICK, Wolfgang, KOUWENHOVEN, Mathilde C. M

“…Glioblastomas are notorious for resistance to therapy, which has been attributed to DNA-repair proficiency, a multitude of deregulated molecular pathways, and,…”
Get full text

Identification of a novel population of highly cytotoxic c‐Met‐expressing CD8+ T lymphocytes by Benkhoucha, Mahdia, Molnarfi, Nicolas, Kaya, Gürkan, Belnoue, Elodie, Bjarnadóttir, Kristbjörg, Dietrich, Pierre‐Yves, Walker, Paul R, Martinvalet, Denis, Derouazi, Madiha, Lalive, Patrice H

“…CD8 + cytotoxic T lymphocytes (CTLs) are critical mediators of anti‐tumor immunity, and controlling the mechanisms that govern CTL functions could be crucial…”
Get full text

Characteristics of long-survivor metastatic melanoma after polychemotherapy and interferon: a retrospective study by Py, Céline, De Vito, Claudio, Tsantoulis, Petros, Kaya, Gürkan, Labidi-Galy, Sana Intidhar, Dietrich, Pierre-Yves

“…The development of immunotherapy and tyrosine kinase inhibitors dramatically improved the prognosis of metastatic melanoma. Consequently, chemotherapy is now…”
Get full text

Limits of CD133 as a marker of glioma self‐renewing cells by Clément, Virginie, Dutoit, Valérie, Marino, Denis, Dietrich, Pierre‐Yves, Radovanovic, Ivan

“…In human gliomas, self‐renewing and tumor‐initiating cells are characterized by the expression marker CD133. Although, widely used, the validity of CD133 is…”
Get full text

The first comprehensive genomic characterization of rectal squamous cell carcinoma by Astaras, Christoforos, De Vito, Claudio, Chaskar, Prasad, Bornand, Aurelie, Khanfir, Kaouthar, Sciarra, Amedeo, Letovanec, Igor, Corro, Claudia, Dietrich, Pierre-Yves, Tsantoulis, Petros, Koessler, Thibaud

“…Background Rectal cancers represent 35% of colorectal cancers; 90% are adenocarcinomas, while squamous cell carcinoma accounts for 0.3% of them. Given its…”
Get full text

Complete Remission With Tyrosine Kinase Inhibitors in Renal Cell Carcinoma by ALBIGES, Laurence, OUDARD, Stéphane, LAGUERRE, Brigitte, LEGOUFFE, Eric, KOHSER, Frédéric, DIETRICH, Pierre-Yves, THEODORE, Christine A, ESCUDIER, Bernard, NEGRIER, Sylvie, CATY, Armelle, GRAVIS, Gwenaëlle, JOLY, Florence, DUCLOS, Brigitte, GEOFFROIS, Lionel, ROLLAND, Frédéric, GUILLOT, Aline

“…Complete remission (CR) is uncommon during treatment for metastatic renal cell carcinoma (mRCC) with tyrosine kinase inhibitors (TKIs), but it may occur in…”
Get full text

Primordial germ cells as a potential shared cell of origin for mucinous cystic neoplasms of the pancreas and mucinous ovarian tumors by Elias, Kevin M, Tsantoulis, Petros, Tille, Jean‐Christophe, Vitonis, Allison, Doyle, Leona A, Hornick, Jason L, Kaya, Gurkan, Barnes, Laurent, Cramer, Daniel W, Puppa, Giacomo, Stuckelberger, Sarah, Hooda, Jagmohan, Dietrich, Pierre‐Yves, Goggins, Michael, Kerr, Candace L, Birrer, Michael, Hirsch, Michelle S, Drapkin, Ronny, Labidi‐Galy, Sana Intidhar

“…Mucinous ovarian tumors (MOTs) morphologically and epidemiologically resemble mucinous cystic neoplasms (MCNs) of the pancreas, sharing a similar stroma and…”
Get full text

Phenotypic switch of CD8+ T cells reactivated under hypoxia toward IL‐10 secreting, poorly proliferative effector cells by Vuillefroy de Silly, Romain, Ducimetière, Laura, Yacoub Maroun, Céline, Dietrich, Pierre‐Yves, Derouazi, Madiha, Walker, Paul R.

“…CD8+ T cells controlling pathogens or tumors must function at sites where oxygen tension is frequently low, and never as high as under atmospheric culture…”
Get full text