Search Results - "Dietrich, Philipp A"

Evaluation of the in vitro and in vivo efficacy of the JAK inhibitor AZD1480 against JAK-mutated acute lymphoblastic leukemia by Suryani, Santi, Bracken, Lauryn S, Harvey, Richard C, Sia, Keith C S, Carol, Hernan, Chen, I-Ming, Evans, Kathryn, Dietrich, Philipp A, Roberts, Kathryn G, Kurmasheva, Raushan T, Billups, Catherine A, Mullighan, Charles G, Willman, Cheryl L, Loh, Mignon L, Hunger, Stephen P, Houghton, Peter J, Smith, Malcolm A, Lock, Richard B

“…Genome-wide studies have identified a high-risk subgroup of pediatric acute lymphoblastic leukemia (ALL) harboring mutations in the Janus kinases (JAK). The…”
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GPR84 sustains aberrant β-catenin signaling in leukemic stem cells for maintenance of MLL leukemogenesis by Dietrich, Philipp A., Yang, Chen, Leung, Halina H.L., Lynch, Jennifer R., Gonzales, Estrella, Liu, Bing, Haber, Michelle, Norris, Murray D., Wang, Jianlong, Wang, Jenny Yingzi

“…β-catenin is required for establishment of leukemic stem cells (LSCs) in acute myeloid leukemia (AML). Targeted inhibition of β-catenin signaling has been…”
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p53-independent epigenetic repression of the p21(WAF1) gene in T-cell acute lymphoblastic leukemia by Davies, Carwyn, Hogarth, Linda A, Dietrich, Philipp A, Bachmann, Petra S, Mackenzie, Karen L, Hall, Andrew G, Lock, Richard B

“…The p53 protein is a primary mediator of cellular apoptosis and growth arrest after exposure to DNA-damaging agents. Previous work has shown that the majority…”
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GNA13, a Novel Component of the GPR84/Beta-Catenin Signaling Axis in AML Stem Cells, Regulates the Maintenance of MLLAF9 Leukemogenesis by Dietrich, Philipp A, Norris, Murray D, Wang, Jenny Yingzi

“…Beta-catenin is required for the establishment of leukemic stem cells (LSC) in mixed lineage leukemia (MLL)-rearranged acute myeloid leukemia (AML). Targeted…”
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GPR84, a Proinflammatory Receptor, Sustains Wnt/β-Catenin Signaling In Leukemic Stem Cells For Maintenance Of MLL-AF9-Induced Leukemogenesis by Dietrich, Philipp A, Norris, Murray D, Wang, Jenny Yingzi

“…Inappropriate activation of Wnt/β-catenin signaling confers hematopoietic progenitors the property of self-renewal that promotes malignant transformation in…”
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p53-independent Epigenetic Repression of the p21WAF1 Gene in T-cell Acute Lymphoblastic Leukemia by Davies, Carwyn, Hogarth, Linda A., Dietrich, Philipp A., Bachmann, Petra S., Mackenzie, Karen L., Hall, Andrew G., Lock, Richard B.

“…The p53 protein is a primary mediator of cellular apoptosis and growth arrest after exposure to DNA-damaging agents. Previous work has shown that the majority…”
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Abstract 2196: Upregulation of survivin during immortalization is linked to repression of p16INK4a and confers resistance to oxidative stress by Petti, Carlotta, Kan, Chin-Yi, Dietrich, Philipp A., Lauryn, Bracken, Xu, Ning, Yuan, Jun, Liu, Tao, MacKenzie, Karen L.

“…Abstract Survivin is an essential component of the chromosomal passenger complex and a member of the Inhibitor of Apoptosis (IAP) family. It is expressed at…”
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