Search Results - "Dieterle, W"

Pharmacokinetic interactions of the oral renin inhibitor aliskiren with lovastatin, atenolol, celecoxib and cimetidine by Dieterle, W, Corynen, S, Vaidyanathan, S, Mann, J

“…Aliskiren is the first in a new class of orally effective renin inhibitors for the treatment of hypertension. This study investigated the interaction profile…”
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Early preclinical development of PQR309, a novel balanced dual PI3K/mTOR inhibitor for treatment of various cancer types by Ettlin, R., Dieterle, W., Fabbro, D., Hebeisen, P., Beaufils, F., Hillmann, P., Stumm, M., Dimitrijević, S., Wymann, M., Cmiljanovic, N., Giese, B., Cmiljanovic, V.

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Absolute bioavailability and pharmacokinetics of avosentan in man by Dieterle, W, Hengelage, T

“…Avosentan is a potent, selective endothelin A receptor blocker. The pharmacokinetics of avosentan were investigated in healthy male and female volunteers,…”
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Influence of food intake on the pharmacokinetics of avosentan in man by Dieterle, W, Hengelage, T

“…Avosentan is a potent, selective endothelin A receptor blocker. The effect of food intake on the pharmacokinetics of avosentan was investigated in healthy…”
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Influence of avosentan (SPP3OI) on the pharmacokinetics of a second generation oral contraceptive containing ethinylestradiol and levonorgestrel in healthy female volunteers by Dieterle, W, Mann, J

“…Avosentan (SPP301) is a potent and highly selective ETA receptor blocker and is clinically investigated in diabetic nephropathy. This study was designed to…”
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Pharmacokinetic interaction between ketoconazole and SPP301 in healthy volunteers by Dieterle, W, Mann, J

“…SPP301 is a potent and highly selective ETA receptor blocker. The primary aim of the present study was to investigate the effect of the potent CYP3A4 inhibitor…”
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Clinical pharmacology and pharmacokinetics of oxcarbazepine by Lloyd, P, Flesch, G, Dieterle, W

“…Oxcarbazepine (OCBZ) is a new antiepileptic drug (AED) structurally related to carbamazepine (CBZ) but differing in several important aspects, notably…”
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Disposition and metabolism of ralfinamide, a novel Na-channel blocker, in healthy male volunteers by Bauer, M, Bliesath, H, Leuratti, C, Lackner, E, Dieterle, W, Müller, M, Brunner, M

“…Ralfinamide is an α-aminoamide derivative with ion channel blocking properties, acting both peripherally and centrally through different molecular targets…”
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Development and validation of a disease-specific questionnaire on the quality of life of patients with chronic venous insufficiency by Augustin, M, Dieterle, W, Zschocke, I, Brill, C, Trefzer, D, Peschen, M, Schöpf, E, Vanscheidt, W

“…Recording of Quality of Life (QoL) is taking on increasing importance in medicine. Although QoL cannot be measured directly, numerous methods studies have…”
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LAN based data communication in modern energy management systems (EMS) by Dieterle, W., Kochs, H.-D., Dittmar, E.

“…The use of energy management systems (EMS) demands high reliability, real-time behaviour and more and more economical systems. The last demand requires use of…”
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Craniofacial and TMJ effects after glutamate and TRH microsphere implantation in proximity to trigeminal motoneurons of growing rats by Byrd, K E, Sukay, M J, Dieterle, M W, Yang, L, Marting, T C, Teomim, D, Domb, A J

“…The sequelae of sustained, in vivo delivery of two important neurotransmitter substances, glutamate and thyrotropin-releasing hormone (TRH), upon craniofacial…”
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Communication architectures for distributed computer control systems by Dieterle, W., Kochs, H.-., Dittmar, E.

“…The use of distributed computer control systems (DCCS) demands high reliability, adequate real-time behaviour and increasingly economical systems. The last…”
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Effect of the oral renin inhibitor aliskiren on the pharmacokinetics and pharmacodynamics of a single dose of warfarin in healthy subjects by Dieterle, Walter, Corynen, Sophie, Mann, Jessica

“…Aims To investigate the effects of aliskiren, an oral renin inhibitor, on the pharmacokinetics and pharmacodynamics of warfarin. Methods In a single‐blind,…”
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Pharmacokinetics and pharmacodynamics of benazepril hydrochloride in patients with major proteinuria by SCHWEIZER, C, KAISER, G, DIETERLE, W, MANN, J

“…We have investigated whether the pharmacokinetics and pharmacodynamics of the ACE inhibitor benazepril hydrochloride are altered with proteinuria by studying 8…”
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Comparison of plasma and saliva concentrations of the active monohydroxy metabolite of oxcarbazepine in patients at steady state by Cardot, J M, Degen, P, Flesch, G, Menge, P, Dieterle, W

“…A study was performed in ten patients, stabilized with oxcarbazepine monotherapy (450-750 mg bid) for two weeks minimum, to investigate the possibility of…”
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The influence of food on the disposition of the antiepileptic oxcarbazepine and its major metabolites in healthy volunteers by Degen, P H, Flesch, G, Cardot, J M, Czendlik, C, Dieterle, W

“…The effect of food on the pharmacokinetics of the antiepileptic oxcarbazepine (OXC) was investigated in healthy volunteers. Six healthy male volunteers were…”
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Pharmacokinetics and pharmacodynamics of the ace inhibitor benazepril hydrochloride in the elderly by KAISER, G, ACKERMANN, R, DIETERLE, W, DURNIN, C. J, MCEWEN, J, GHOSE, K, RICHENS, A, HOLMES, I. B

“…The pharmacokinetics and pharmacodynamics of a single oral dose benazepril.HCl 10 mg have been studied in 15 healthy volunteers aged 65 to 80 y. The kinetics…”
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Determination of the antidepressant levoprotiline and its N-desmethyl metabolite in biological fluids by gas chromatography/mass spectrometry by Ackermann, R, Kaiser, G, Schueller, F, Dieterle, W

“…A specific and sensitive gas chromatographic/mass spectrometric method was developed and validated for the determination of the antidepressant levoprotiline in…”
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Influence of food on the disposition of the monoamine oxidase-A inhibitor brofaromine in healthy volunteers by Degen, P H, Cardot, J M, Czendlik, C, Dieterle, W

“…The effect of food on the bioavailability of brofaromine hydrochloride was investigated in a randomized cross-over study. Eight healthy male volunteers were…”
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Multiple inverse isotope dilution assay for the stereospecific quantitative determination of R(-) and S(+)-oxaprotiline in biological fluids by Dieterle, W, Faigle, J W

“…An isotope dilution assay for the determination of both oxaprotiline enantiomers in biological samples after administration of the racemic mixture has been…”
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