Search Results - "Dieterlé, Stéphane"

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss by Scekic-Zahirovic, Jelena, Sendscheid, Oliver, El Oussini, Hajer, Jambeau, Mélanie, Sun, Ying, Mersmann, Sina, Wagner, Marina, Dieterlé, Stéphane, Sinniger, Jérome, Dirrig-Grosch, Sylvie, Drenner, Kevin, Birling, Marie-Christine, Qiu, Jinsong, Zhou, Yu, Li, Hairi, Fu, Xiang-Dong, Rouaux, Caroline, Shelkovnikova, Tatyana, Witting, Anke, Ludolph, Albert C, Kiefer, Friedemann, Storkebaum, Erik, Lagier-Tourenne, Clotilde, Dupuis, Luc

“…FUS is an RNA‐binding protein involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cytoplasmic FUS‐containing aggregates are…”
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Evaluation of a 5-HT2B receptor agonist in a murine model of amyotrophic lateral sclerosis by Arnoux, Alizée, Ayme-Dietrich, Estelle, Dieterle, Stéphane, Goy, Marc-Antoine, Schann, Stephan, Frauli, Mélanie, Monassier, Laurent, Dupuis, Luc

“…Degeneration of brainstem serotonin neurons has been demonstrated in ALS patients and mouse models and was found responsible for the development of spasticity…”
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FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis by Picchiarelli, Gina, Demestre, Maria, Zuko, Amila, Been, Marije, Higelin, Julia, Dieterlé, Stéphane, Goy, Marc-Antoine, Mallik, Moushami, Sellier, Chantal, Scekic-Zahirovic, Jelena, Zhang, Li, Rosenbohm, Angela, Sijlmans, Céline, Aly, Amr, Mersmann, Sina, Sanjuan-Ruiz, Inmaculada, Hübers, Annemarie, Messaddeq, Nadia, Wagner, Marina, van Bakel, Nick, Boutillier, Anne-Laurence, Ludolph, Albert, Lagier-Tourenne, Clotilde, Boeckers, Tobias M., Dupuis, Luc, Storkebaum, Erik

“…Neuromuscular junction (NMJ) disruption is an early pathogenic event in amyotrophic lateral sclerosis (ALS). Yet, direct links between NMJ pathways and…”
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Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis by Scekic-Zahirovic, Jelena, Oussini, Hajer El, Mersmann, Sina, Drenner, Kevin, Wagner, Marina, Sun, Ying, Allmeroth, Kira, Dieterlé, Stéphane, Sinniger, Jérôme, Dirrig-Grosch, Sylvie, René, Frédérique, Dormann, Dorothee, Haass, Christian, Ludolph, Albert C., Lagier-Tourenne, Clotilde, Storkebaum, Erik, Dupuis, Luc

“…Motor neuron-extrinsic mechanisms have been shown to participate in the pathogenesis of ALS-SOD1, one familial form of amyotrophic lateral sclerosis (ALS). It…”
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Alterations in the hypothalamic melanocortin pathway in amyotrophic lateral sclerosis by Vercruysse, Pauline, Sinniger, Jérôme, El Oussini, Hajer, Scekic-Zahirovic, Jelena, Dieterlé, Stéphane, Dengler, Reinhard, Meyer, Thomas, Zierz, Stephan, Kassubek, Jan, Fischer, Wilhelm, Dreyhaupt, Jens, Grehl, Torsten, Hermann, Andreas, Grosskreutz, Julian, Witting, Anke, Van Den Bosch, Ludo, Spreux-Varoquaux, Odile, Ludolph, Albert C, Dupuis, Luc

“…Amyotrophic lateral sclerosis, the most common adult-onset motor neuron disease, leads to death within 3 to 5 years after onset. Beyond progressive motor…”
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Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression by Canet-Pons, Júlia, Sen, Nesli-Ece, Arsović, Aleksandar, Almaguer-Mederos, Luis-Enrique, Halbach, Melanie V., Key, Jana, Döring, Claudia, Kerksiek, Anja, Picchiarelli, Gina, Cassel, Raphaelle, René, Frédérique, Dieterlé, Stéphane, Fuchs, Nina V., König, Renate, Dupuis, Luc, Lütjohann, Dieter, Gispert, Suzana, Auburger, Georg

“…Large polyglutamine expansions in Ataxin-2 (ATXN2) cause multi-system nervous atrophy in Spinocerebellar Ataxia type 2 (SCA2). Intermediate size expansions…”
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Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects by Scekic-Zahirovic, Jelena, Sanjuan-Ruiz, Inmaculada, Kan, Vanessa, Megat, Salim, De Rossi, Pierre, Dieterlé, Stéphane, Cassel, Raphaelle, Jamet, Marguerite, Kessler, Pascal, Wiesner, Diana, Tzeplaeff, Laura, Demais, Valérie, Sahadevan, Sonu, Hembach, Katharina M., Muller, Hans-Peter, Picchiarelli, Gina, Mishra, Nibha, Antonucci, Stefano, Dirrig-Grosch, Sylvie, Kassubek, Jan, Rasche, Volker, Ludolph, Albert, Boutillier, Anne-Laurence, Roselli, Francesco, Polymenidou, Magdalini, Lagier-Tourenne, Clotilde, Liebscher, Sabine, Dupuis, Luc

“…Gene mutations causing cytoplasmic mislocalization of the RNA-binding protein FUS lead to severe forms of amyotrophic lateral sclerosis (ALS). Cytoplasmic…”
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Degeneration of serotonin neurons triggers spasticity in amyotrophic lateral sclerosis by El Oussini, Hajer, Scekic‐Zahirovic, Jelena, Vercruysse, Pauline, Marques, Christine, Dirrig‐Grosch, Sylvie, Dieterlé, Stéphane, Picchiarelli, Gina, Sinniger, Jérôme, Rouaux, Caroline, Dupuis, Luc

“…Objective Spasticity occurs in a wide range of neurological diseases, including neurodegenerative diseases, after trauma, and after stroke, and is…”
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Mutant FUS induces chromatin reorganization in the hippocampus and alters memory processes by Tzeplaeff, Laura, Seguin, Jonathan, Le Gras, Stéphanie, Megat, Salim, Cosquer, Brigitte, Plassard, Damien, Dieterlé, Stéphane, Paiva, Isabel, Picchiarelli, Gina, Decraene, Charles, Alcala-Vida, Rafael, Cassel, Jean-Christophe, Merienne, Karine, Dupuis, Luc, Boutillier, Anne-Laurence

“…Cytoplasmic mislocalization of the nuclear Fused in Sarcoma (FUS) protein is associated to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia…”
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Loss of hypothalamic MCH decreases food intake in amyotrophic lateral sclerosis by Bolborea, Matei, Vercruysse, Pauline, Daria, Tselmen, Reiners, Johanna C., Alami, Najwa Ouali, Guillot, Simon J., Dieterlé, Stéphane, Sinniger, Jérôme, Scekic-Zahirovic, Jelena, Londo, Amela, Arcay, Hippolyte, Goy, Marc-Antoine, de Tapia, Claudia Nelson, Thal, Dietmar R., Shibuya, Kazumoto, Otani, Ryo, Arai, Kimihito, Kuwabara, Satoshi, Ludolph, Albert C., Roselli, Francesco, Yilmazer-Hanke, Deniz, Dupuis, Luc

“…Amyotrophic lateral sclerosis (ALS) is associated with impaired energy metabolism, including weight loss and decreased appetite which are negatively correlated…”
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In‐depth analysis of data from the RAS‐ALS study reveals new insights in rasagiline treatment for amyotrophic lateral sclerosis by Schuster, Joachim, Dreyhaupt, Jens, Mönkemöller, Karla, Dupuis, Luc, Dieterlé, Stéphane, Weishaupt, Jochen H., Kassubek, Jan, Petri, Susanne, Meyer, Thomas, Grosskreutz, Julian, Schrank, Berthold, Boentert, Matthias, Emmer, Alexander, Hermann, Andreas, Zeller, Daniel, Prudlo, Johannes, Winkler, Andrea S., Grehl, Torsten, Heneka, Michael T., Johannesen, Siw, Göricke, Bettina, Witzel, Simon, Dorst, Johannes, Ludolph, Albert C.

“…Background and purpose In 2016, we concluded a randomized controlled trial testing 1 mg rasagiline per day add‐on to standard therapy in 252 amyotrophic…”
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Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis by El Oussini, Hajer, Bayer, Hanna, Scekic-Zahirovic, Jelena, Vercruysse, Pauline, Sinniger, Jérôme, Dirrig-Grosch, Sylvie, Dieterlé, Stéphane, Echaniz-Laguna, Andoni, Larmet, Yves, Müller, Kathrin, Weishaupt, Jochen H., Thal, Dietmar R., van Rheenen, Wouter, van Eijk, Kristel, Lawson, Roland, Monassier, Laurent, Maroteaux, Luc, Roumier, Anne, Wong, Philip C., van den Berg, Leonard H., Ludolph, Albert C., Veldink, Jan H., Witting, Anke, Dupuis, Luc

“…Microglia are the resident mononuclear phagocytes of the central nervous system and have been implicated in the pathogenesis of neurodegenerative diseases such…”
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Low dietary protein content alleviates motor symptoms in mice with mutant dynactin/dynein-mediated neurodegeneration by Wiesner, Diana, Sinniger, Jérome, Henriques, Alexandre, Dieterlé, Stéphane, Müller, Hans-Peter, Rasche, Volker, Ferger, Boris, Dirrig-Grosch, Sylvie, Soylu-Kucharz, Rana, Petersén, Asa, Walther, Paul, Linkus, Birgit, Kassubek, Jan, Wong, Philip C, Ludolph, Albert C, Dupuis, Luc

“…Mutations in components of the molecular motor dynein/dynactin lead to neurodegenerative diseases of the motor system or atypical parkinsonism. These mutations…”
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Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation by Sanjuan-Ruiz, Inmaculada, Govea-Perez, Noé, McAlonis-Downes, Melissa, Dieterle, Stéphane, Megat, Salim, Dirrig-Grosch, Sylvie, Picchiarelli, Gina, Piol, Diana, Zhu, Qiang, Myers, Brian, Lee, Chao-Zong, Cleveland, Don W, Lagier-Tourenne, Clotilde, Da Cruz, Sandrine, Dupuis, Luc

“…Mutations in FUS, an RNA-binding protein involved in multiple steps of RNA metabolism, are associated with the most severe forms of amyotrophic lateral…”
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Integrative genetic analysis illuminates ALS heritability and identifies risk genes by Megat, Salim, Mora, Natalia, Sanogo, Jason, Roman, Olga, Catanese, Alberto, Alami, Najwa Ouali, Freischmidt, Axel, Mingaj, Xhuljana, De Calbiac, Hortense, Muratet, François, Dirrig-Grosch, Sylvie, Dieterle, Stéphane, Van Bakel, Nick, Müller, Kathrin, Sieverding, Kirsten, Weishaupt, Jochen, Andersen, Peter Munch, Weber, Markus, Neuwirth, Christoph, Margelisch, Markus, Sommacal, Andreas, Van Eijk, Kristel R., Veldink, Jan H., Lautrette, Géraldine, Couratier, Philippe, Camuzat, Agnès, Le Ber, Isabelle, Grassano, Maurizio, Chio, Adriano, Boeckers, Tobias, Ludolph, Albert C., Roselli, Francesco, Yilmazer-Hanke, Deniz, Millecamps, Stéphanie, Kabashi, Edor, Storkebaum, Erik, Sellier, Chantal, Dupuis, Luc

“…Amyotrophic lateral sclerosis (ALS) has substantial heritability, in part shared with fronto-temporal dementia (FTD). We show that ALS heritability is enriched…”
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Author Correction: Integrative genetic analysis illuminates ALS heritability and identifies risk genes by Megat, Salim, Mora, Natalia, Sanogo, Jason, Roman, Olga, Catanese, Alberto, Alami, Najwa Ouali, Freischmidt, Axel, Mingaj, Xhuljana, De Calbiac, Hortense, Muratet, François, Dirrig-Grosch, Sylvie, Dieterle, Stéphane, Van Bakel, Nick, Müller, Kathrin, Sieverding, Kirsten, Weishaupt, Jochen, Andersen, Peter Munch, Weber, Markus, Neuwirth, Christoph, Margelisch, Markus, Sommacal, Andreas, Van Eijk, Kristel R., Veldink, Jan H., Lautrette, Géraldine, Couratier, Philippe, Camuzat, Agnès, Le Ber, Isabelle, Grassano, Maurizio, Chio, Adriano, Boeckers, Tobias, Ludolph, Albert C., Roselli, Francesco, Yilmazer-Hanke, Deniz, Millecamps, Stéphanie, Kabashi, Edor, Storkebaum, Erik, Sellier, Chantal, Dupuis, Luc

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Mutant FUS induces chromatin reorganization in the hippocampus and alters memory processes by Tzeplaeff, Laura, Seguin, Jonathan, Le Gras, Stéphanie, Megat, Salim, Cosquer, Brigitte, Plassard, Damien, Dieterlé, Stéphane, Paiva, Isabel, Picchiarelli, Gina, Decraene, Charles, Alcala-Vida, Rafael, Cassel, Jean-Christophe, Merienne, Karine, Dupuis, Luc, Boutillier, Anne-Laurence

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Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects by Scekic-Zahirovic, Jelena, Sanjuan-Ruiz, Inmaculada, Kan, Vanessa, Megat, Salim, de Rossi, Pierre, Dieterlé, Stéphane, Cassel, Raphaelle, Jamet, Marguerite, Kessler, Pascal, Wiesner, Diana, Tzeplaeff, Laura, Demais, Valérie, Sahadevan, Sonu, Hembach, Katharina, Muller, Hans-Peter, Picchiarelli, Gina, Mishra, Nibha, Antonucci, Stefano, Dirrig-Grosch, Sylvie, Kassubek, Jan, Rasche, Volker, Ludolph, Albert, Boutillier, Anne-Laurence, Roselli, Francesco, Polymenidou, Magdalini, Lagier-Tourenne, Clotilde, Liebscher, Sabine, Dupuis, Luc

“…Gene mutations causing cytoplasmic mislocalization of the RNA-binding protein FUS lead to severe forms of amyotrophic lateral sclerosis (ALS). Cytoplasmic…”
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Evaluation of a 5-HT 2B receptor agonist in a murine model of amyotrophic lateral sclerosis by Arnoux, Alizée, Ayme-Dietrich, Estelle, Dieterle, Stéphane, Goy, Marc-Antoine, Schann, Stephan, Frauli, Mélanie, Monassier, Laurent, Dupuis, Luc

“…Degeneration of brainstem serotonin neurons has been demonstrated in ALS patients and mouse models and was found responsible for the development of spasticity…”
Get full text