Search Results - "Dietbert Neumann"

Is TAK1 a Direct Upstream Kinase of AMPK? by Neumann, Dietbert

“…Alongside Liver kinase B1 (LKB1) and Ca /Calmodulin-dependent protein kinase kinase 2 (CaMKK2), Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1)…”
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AMP-Activated Protein Kinase Signalling by Neumann, Dietbert, Viollet, Benoit

“…AMP-activated protein kinase (AMPK) regulates energy homeostasis in eukaryotic cells and organisms [...]…”
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AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy by Dohmen, Marc, Krieg, Sarah, Agalaridis, Georgios, Zhu, Xiaoqing, Shehata, Saifeldin N., Pfeiffenberger, Elisabeth, Amelang, Jan, Bütepage, Mareike, Buerova, Elena, Pfaff, Carolina M., Chanda, Dipanjan, Geley, Stephan, Preisinger, Christian, Sakamoto, Kei, Lüscher, Bernhard, Neumann, Dietbert, Vervoorts, Jörg

“…The AMP-activated protein kinase (AMPK) is a master sensor of the cellular energy status that is crucial for the adaptive response to limited energy…”
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Dissecting the Role of 5′-AMP for Allosteric Stimulation, Activation, and Deactivation of AMP-activated Protein Kinase by Suter, Marianne, Riek, Uwe, Tuerk, Roland, Schlattner, Uwe, Wallimann, Theo, Neumann, Dietbert

“…AMP-activated protein kinase (AMPK) is a heterotrimeric protein kinase that is crucial for cellular energy homeostasis of eukaryotic cells and organisms. Here…”
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Specific Compounds Derived from Traditional Chinese Medicine Ameliorate Lipid-Induced Contractile Dysfunction in Cardiomyocytes by Wang, Fang, Neumann, Dietbert, Kapsokalyvas, Dimitris, Hoes, Martijn F, Schianchi, Francesco, Glatz, Jan F C, Nabben, Miranda, Luiken, Joost J F P

“…Chronic lipid overconsumption, associated with the Western diet, causes excessive cardiac lipid accumulation, insulin resistance, and contractile dysfunction,…”
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LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade by Woods, Angela, Johnstone, Stephen R., Dickerson, Kristina, Leiper, Fiona C., Fryer, Lee G.D., Neumann, Dietbert, Schlattner, Uwe, Wallimann, Theo, Carlson, Marian, Carling, David

“…Inactivating mutations in the protein kinase LKB1 lead to a dominantly inherited cancer in humans termed Peutz-Jeghers syndrome [1, 2]. The role of LKB1 is…”
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Putative Role of Protein Palmitoylation in Cardiac Lipid-Induced Insulin Resistance by Schianchi, Francesco, Glatz, Jan F C, Navarro Gascon, Artur, Nabben, Miranda, Neumann, Dietbert, Luiken, Joost J F P

“…In the heart, inhibition of the insulin cascade following lipid overload is strongly associated with contractile dysfunction. The translocation of fatty acid…”
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Ketone Body Exposure of Cardiomyocytes Impairs Insulin Sensitivity and Contractile Function through Vacuolar-Type H+-ATPase Disassembly—Rescue by Specific Amino Acid Supplementation by Wang, Shujin, Neumann, Dietbert, Westenbrink, B. Daan, Schianchi, Francesco, Wong, Li-Yen, Sun, Aomin, Strzelecka, Agnieszka, Glatz, Jan F. C., Luiken, Joost J. F. P., Nabben, Miranda

“…The heart is metabolically flexible. Under physiological conditions, it mainly uses lipids and glucose as energy substrates. In uncontrolled diabetes, the…”
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Augmenting Vacuolar H + -ATPase Function Prevents Cardiomyocytes from Lipid-Overload Induced Dysfunction by Wang, Shujin, Wong, Li-Yen, Neumann, Dietbert, Liu, Yilin, Sun, Aomin, Antoons, Gudrun, Strzelecka, Agnieszka, Glatz, Jan F C, Nabben, Miranda, Luiken, Joost J F P

“…The diabetic heart is characterized by a shift in substrate utilization from glucose to lipids, which may ultimately lead to contractile dysfunction. This…”
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The Recruitment of AMP-activated Protein Kinase to Glycogen Is Regulated by Autophosphorylation by Oligschlaeger, Yvonne, Miglianico, Marie, Chanda, Dipanjan, Scholz, Roland, Thali, Ramon F., Tuerk, Roland, Stapleton, David I., Gooley, Paul R., Neumann, Dietbert

“…The mammalian AMP-activated protein kinase (AMPK) is an obligatory αβγ heterotrimeric complex carrying a carbohydrate-binding module (CBM) in the β-subunit…”
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Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR–v-ATPase axis by Wang, Shujin, Schianchi, Francesco, Neumann, Dietbert, Wong, Li-Yen, Sun, Aomin, van Nieuwenhoven, Frans A., Zeegers, Maurice P., Strzelecka, Agnieszka, Col, Umare, Glatz, Jan F.C., Nabben, Miranda, Luiken, Joost J.F.P.

“…The diabetic heart is characterized by extensive lipid accumulation which often leads to cardiac contractile dysfunction. The underlying mechanism involves a…”
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Dietary Phytoestrogens Activate AMP-Activated Protein Kinase With Improvement in Lipid and Glucose Metabolism by CEDERROTH, Christopher R, VINCIGUERRA, Manlio, DOERGE, Daniel R, WALLIMANN, Theo, MEDA, Paolo, FOTI, Michelangelo, ROHNER-JEANRENAUD, Francoise, VASSALLI, Jean-Dominique, NEF, Serge, GJINOVCI, Asllan, KÜHNE, Francoise, KLEIN, Marcella, CEDERROTH, Manon, CAILLE, Dorothée, SUTER, Mariane, NEUMANN, Dietbert, JAMES, Richard W

“…Dietary Phytoestrogens Activate AMP-Activated Protein Kinase With Improvement in Lipid and Glucose Metabolism Christopher R. Cederroth 1 , Manlio Vinciguerra 2…”
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Identification of the Serine 307 of LKB1 as a Novel Phosphorylation Site Essential for Its Nucleocytoplasmic Transport and Endothelial Cell Angiogenesis by Xie, Zhonglin, Dong, Yunzhou, Zhang, Junhua, Scholz, Roland, Neumann, Dietbert, Zou, Ming-Hui

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Genome-scale metabolic network of human carotid plaque reveals the pivotal role of glutamine/glutamate metabolism in macrophage modulating plaque inflammation and vulnerability by Jin, Han, Zhang, Cheng, Nagenborg, Jan, Juhasz, Peter, Ruder, Adele V, Sikkink, Cornelis J J M, Mees, Barend M E, Waring, Olivia, Sluimer, Judith C, Neumann, Dietbert, Goossens, Pieter, Donners, Marjo M P C, Mardinoglu, Adil, Biessen, Erik A L

“…Metabolism is increasingly recognized as a key regulator of the function and phenotype of the primary cellular constituents of the atherosclerotic vascular…”
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Phosphocreatine interacts with phospholipids, affects membrane properties and exerts membrane-protective effects by Tokarska-Schlattner, Malgorzata, Epand, Raquel F, Meiler, Flurina, Zandomeneghi, Giorgia, Neumann, Dietbert, Widmer, Hans R, Meier, Beat H, Epand, Richard M, Saks, Valdur, Wallimann, Theo, Schlattner, Uwe

“…A broad spectrum of beneficial effects has been ascribed to creatine (Cr), phosphocreatine (PCr) and their cyclic analogues cyclo-(cCr) and…”
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AMP-activated Protein Kinase Phosphorylates and Desensitizes Smooth Muscle Myosin Light Chain Kinase by Horman, Sandrine, Morel, Nicole, Vertommen, Didier, Hussain, Nusrat, Neumann, Dietbert, Beauloye, Christophe, Najjar, Nicole El, Forcet, Christelle, Viollet, Benoit, Walsh, Michael P., Hue, Louis, Rider, Mark H.

“…Smooth muscle contraction is initiated by a rise in intracellular calcium, leading to activation of smooth muscle myosin light chain kinase (MLCK) via…”
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β1Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells by Ho, Pei-Yin, Li, Hui, Pavlov, Tengis S., Tuerk, Roland D., Tabares, Diego, Brunisholz, René, Neumann, Dietbert, Staruschenko, Alexander, Hallows, Kenneth R.

“…Our previous work has established that the metabolic sensor AMP-activated protein kinase (AMPK) inhibits the epithelial Na+ channel (ENaC) by promoting its…”
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Fluorescent labelling of membrane fatty acid transporter CD36 (SR-B2) in the extracellular loop by Liu, Yilin, Rodriguez-Calvo, Ricardo, Wang, Shujin, Zhu, Xiaoqing, Broers, Jos L V, Glatz, Jan F C, Luiken, Joost J F P, Neumann, Dietbert

“…Upon palmitate oversupply, membrane fatty acid-transporter CD36 (SR-B2) permanently translocates from endosomal storage to the sarcolemma, inducing…”
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AMP-activated Kinase Inhibits the Epithelial Na+ Channel through Functional Regulation of the Ubiquitin Ligase Nedd4-2 by Bhalla, Vivek, Oyster, Nicholas M., Fitch, Adam C., Wijngaarden, Marjolein A., Neumann, Dietbert, Schlattner, Uwe, Pearce, David, Hallows, Kenneth R.

“…We recently found that the metabolic sensor AMP-activated kinase (AMPK) inhibits the epithelial Na+ channel (ENaC) through decreased plasma membrane ENaC…”
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Endosomal v-ATPase as a Sensor Determining Myocardial Substrate Preference by Wang, Shujin, Han, Yinying, Nabben, Miranda, Neumann, Dietbert, Luiken, Joost J. F. P., Glatz, Jan F. C.

“…The heart is a metabolically flexible omnivore that can utilize a variety of substrates for energy provision. To fulfill cardiac energy requirements, the…”
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