Search Results - "Dierov, Jamil K."

A Phase I Study of the Mammalian Target of Rapamycin Inhibitor Sirolimus and MEC Chemotherapy in Relapsed and Refractory Acute Myelogenous Leukemia by Perl, Alexander E, Kasner, Margaret T, Tsai, Donald E, Vogl, Dan T, Loren, Alison W, Schuster, Stephen J, Porter, David L, Stadtmauer, Edward A, Goldstein, Steven C, Frey, Noelle V, Nasta, Sunita D, Hexner, Elizabeth O, Dierov, Jamil K, Swider, Cezary R, Bagg, Adam, Gewirtz, Alan M, Carroll, Martin, Luger, Selina M

“…Purpose: Inhibiting mammalian target of rapamycin (mTOR) signaling in acute myelogenous leukemia (AML) blasts and leukemic stem cells may enhance their…”
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TEL-JAK2 constitutively activates the extracellular signal–regulated kinase (ERK), stress-activated protein/Jun kinase (SAPK/JNK), and p38 signaling pathways by Ho, Jenny M.-Y., Nguyen, Melody H.-H., Dierov, Jamil K., Badger, Karla M., Beattie, Bryan K., Tartaro, Piero, Haq, Rizwan, Zanke, Brent W., Carroll, Martin P., Barber, Dwayne L.

“…The ets transcription factor, TEL, undergoes chromosomal rearrangements with the tyrosine kinase JAK2. TEL-JAK2 is constitutively active, confers cell line…”
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CML Progenitor Cells Have Chromsomal Instability and Display Increased DNA Damage at DNA Fragile Sites by Dierov, Jamil K., Schoppy, David W., Carroll, Martin

“…Chronic myelogeneous leukemia (CML) is a two stage disease which progresses to blast crisis over a period of 3–5 years in untreated patients. The BCR/ABL…”
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Phosphoproteomic Analysis of Primary Acute Myeloid Leukemia Cells Reveals Redundant Roles for Src Family Kinases in AML Survival by Dierov, Jamil K., Kim, Tae Kon, Yang, Xiaowei, Perl, Alexander, Burke, Beth A, Wang, Zhu, Gu, Ting-Lei, Gewirtz, Alan M., Corey, Seth J., Polakiewicz, Roberto, Carroll, Martin

“…Recent results have demonstrated that multiple signal transduction pathways are activated in acute myeloid leukemia (AML) cells, however, the tyrosine…”
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A Phase I Dose Escalation Study of the mTOR Inhibitor Sirolimus and MEC Chemotherapy Targeting Signal Transduction in Leukemic Stem Cells for Acute Myeloid Leukemia by Luger, Selina, Perl, Alexander, Kemner, Allison, Stadtmauer, Edward A., Porter, David, Schuster, Stephen J., Goldstein, Stephen C., Tsai, Donald E., Nasta, S., Loren, A., Dierov, Jamil K., Vogl, D., Andreadis, C., Emerson, Stephen G., Carroll, Martin

“…In vitro studies have suggested that AML cells are sensitive to treatment with the mammalian target of rapamycin (mTOR) inhibitor, rapamycin. In particular,…”
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