Search Results - "Diercks, Philipp"

Integration of nicotinic acid adenine dinucleotide phosphate (NAADP)‐dependent calcium signalling by Guse, Andreas H., Diercks, Björn‐Philipp

“…Nicotinic acid adenine dinucleotide phosphate (NAADP) is currently the most potent endogenous Ca2+ mobilizing second messenger. Upon specific extracellular…”
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Mechanisms and functions of calcium microdomains produced by ORAI channels, d-myo-inositol 1,4,5-trisphosphate receptors, or ryanodine receptors by Guse, Andreas H., Gil Montoya, Diana C., Diercks, Björn-Philipp

“…With the discovery of local Ca2+ signals in the 1990s the concept of ‘elementary Ca2+ signals’ and ‘fundamental Ca2+ signals’ was developed. While ‘elementary…”
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TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer by Perez, Laura Garcia, Kempski, Jan, McGee, Heather M., Pelzcar, Penelope, Agalioti, Theodora, Giannou, Anastasios, Konczalla, Leonie, Brockmann, Leonie, Wahib, Ramez, Xu, Hao, Vesely, Maria Carolina Amezcua, Soukou, Shiwa, Steglich, Babett, Bedke, Tanja, Manthey, Carolin, Seiz, Oliver, Diercks, Björn-Philipp, Gnafakis, Stylianos, Guse, Andreas H., Perez, Daniel, Izbicki, Jakob R., Gagliani, Nicola, Flavell, Richard A., Huber, Samuel

“…IL-22 has dual functions during tumorigenesis. Short term IL-22 production protects against genotoxic stress, whereas uncontrolled IL-22 activity promotes…”
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The actin bundling activity of ITPKA mainly accounts for its migration-promoting effect in lung cancer cells by Küster, Lukas, Paraschiakos, Themistoklis, Karakurt, Kader Ebru, Schumacher, Udo, Diercks, Björn-Philipp, Windhorst, Sabine

“…Expression of Ins(1,4,5)P3-kinase-A (ITPKA), the neuronal isoform of Ins(1,4,5)P3-kinases, is up-regulated in many tumor types. In particular, in lung cancer…”
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P2X7 is expressed on human innate‐like T lymphocytes and mediates susceptibility to ATP‐induced cell death by Winzer, Riekje, Serracant‐Prat, Arnau, Brock, Valerie J., Pinto‐Espinoza, Carolina, Rissiek, Björn, Amadi, Miriam, Eich, Niklas, Rissiek, Anne, Schneider, Enja, Magnus, Tim, Guse, Andreas H., Diercks, Björn‐Philipp, Koch‐Nolte, Friedrich, Tolosa, Eva

“…Extracellular ATP activates the P2X7 receptor, leading to inflammasome activation and release of pro‐inflammatory cytokines in monocytes. However, a detailed…”
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Time-Dependent Image Restoration of Low-SNR Live-Cell Ca2 Fluorescence Microscopy Data by Woelk, Lena-Marie, Kannabiran , Sukanya A., Brock , Valerie J., Gee , Christine E., Lohr , Christian, Guse , Andreas H., Diercks , Björn-Philipp, Werner, René

“…Live-cell Ca2+ fluorescence microscopy is a cornerstone of cellular signaling analysis and imaging. The demand for high spatial and temporal imaging resolution…”
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Time-resolved role of P2X4 and P2X7 during CD8 + T cell activation by Brock, Valerie J, Lory, Niels Christian, Möckl, Franziska, Birus, Melina, Stähler, Tobias, Woelk, Lena-Marie, Jaeckstein, Michelle, Heeren, Joerg, Koch-Nolte, Friedrich, Rissiek, Björn, Mittrücker, Hans-Willi, Guse, Andreas H, Werner, René, Diercks, Björn-Philipp

“…CD8 T cells are a crucial part of the adaptive immune system, responsible for combating intracellular pathogens and tumor cells. The initial activation of T…”
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High Metabolic Function and Resilience of NKG2A-Educated NK Cells by Highton, Andrew J, Diercks, Björn-Philipp, Möckl, Franziska, Martrus, Gloria, Sauter, Jürgen, Schmidt, Alexander H, Bunders, Madeleine J, Körner, Christian, Guse, Andreas H, Altfeld, Marcus

“…Natural killer (NK) cells are an important component of the innate immune system for the control of intracellular pathogens and cancer cells. NK cells…”
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MASTER-NAADP: a membrane permeable precursor of the Ca2+ mobilizing second messenger NAADP by Krukenberg, Sarah, Möckl, Franziska, Weiß, Mariella, Dekiert, Patrick, Hofmann, Melanie, Gerlach, Fynn, Winterberg, Kai J., Kovacevic, Dejan, Khansahib, Imrankhan, Troost, Berit, Hinrichs, Macarena, Granato, Viviana, Nawrocki, Mikolaj, Hub, Tobis, Tsvilovskyy, Volodymyr, Medert, Rebekka, Woelk, Lena-Marie, Förster, Fritz, Li, Huan, Werner, René, Altfeld, Marcus, Huber, Samuel, Clarke, Oliver Biggs, Freichel, Marc, Diercks, Björn-Philipp, Meier, Chris, Guse, Andreas H.

“…Upon stimulation of membrane receptors, nicotinic acid adenine dinucleotide phosphate (NAADP) is formed as second messenger within seconds and evokes Ca 2+…”
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Spatio-temporal feature learning with reservoir computing for T-cell segmentation in live-cell Ca2+ fluorescence microscopy by Hadaeghi, Fatemeh, Diercks, Björn-Philipp, Schetelig, Daniel, Damicelli, Fabrizio, Wolf, Insa M. A., Werner, René

“…Advances in high-resolution live-cell Ca 2 + imaging enabled subcellular localization of early Ca 2 + signaling events in T-cells and paved the way to…”
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DARTS: an open-source Python pipeline for Ca2+ microdomain analysis in live cell imaging data by Woelk, Lena-Marie, Kovacevic, Dejan, Husseini, Hümeyra, Förster, Fritz, Gerlach, Fynn, Möckl, Franziska, Altfeld, Marcus, Guse, Andreas H., Diercks, Björn-Philipp, Werner, René

“…Ca 2+ microdomains play a key role in intracellular signaling processes. For instance, they mediate the activation of T cells and, thus, the initial adaptive…”
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T cell Ca2+ microdomains through the lens of computational modeling by Gil Montoya, Diana C., Ornelas-Guevara, Roberto, Diercks, Björn-Philipp, Guse, Andreas H., Dupont, Geneviève

“…Cellular Ca 2+ signaling is highly organized in time and space. Locally restricted and short-lived regions of Ca 2+ increase, called Ca 2+ microdomains,…”
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Culturing and patch clamping of Jurkat T cells and neurons on Al2O3 coated nanowire arrays of altered morphology by Harberts, Jann, Zierold, Robert, Fendler, Cornelius, Aune Koitmäe, Bayat, Parisa, Fernandez-Cuesta, Irene, Loers, Gabriele, Björn-Philipp Diercks, Fliegert, Ralf, Guse, Andreas H, Ronning, Carsten, Otnes, Gaute, Borgström, Magnus, Blick, Robert H

“…Nanowire substrates play an increasingly important role for cell cultures as an approach for hybrid bio-semiconductor junctions. We investigate Jurkat T cells…”
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Three-Dimensional Model of Sub-Plasmalemmal Ca2+ Microdomains Evoked by T Cell Receptor/CD3 Complex Stimulation by Gil, Diana, Diercks, Björn-Philipp, Guse, Andreas H., Dupont, Geneviève

“…Ca 2+ signalling plays an essential role in T cell activation, which is a key step to start an adaptive immune response. During the transition from a quiescent…”
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Unexpected players for local calcium signals: STIM and ORAI proteins by Diercks, Björn-Philipp, Guse, Andreas H

“…[Display omitted] Ca2+ signaling as the most widespread and universally used signaling system both in the plant and animal kingdom comes in many different…”
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The importance of Ca 2+ microdomains for the adaptive immune response by Diercks, Björn-Philipp

“…Calcium signaling stands out as the most widespread and universally used signaling system and is of utmost importance for immunity. Controlled elevations in…”
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Ultra-fast cell counters based on microtubular waveguides by Bausch, Cornelius S., Heyn, Christian, Hansen, Wolfgang, Wolf, Insa M. A., Diercks, Björn-Philipp, Guse, Andreas H., Blick, Robert H.

“…We present a radio-frequency impedance-based biosensor embedded inside a semiconductor microtube for the in-flow detection of single cells. An…”
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Ca2+ puffs underlie adhesion-triggered Ca2+ microdomains in T cells by Ornelas-Guevara, Roberto, Diercks, Björn-Philipp, Guse, Andreas H., Dupont, Geneviève

“…Ca2+ signalling is pivotal in T cell activation, an essential process in adaptive immune responses. Key to this activation are Ca2+ microdomains, which are…”
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Publisher Correction: TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer by Perez, Laura Garcia, Kempski, Jan, McGee, Heather M., Pelzcar, Penelope, Agalioti, Theodora, Giannou, Anastasios, Konczalla, Leonie, Brockmann, Leonie, Wahib, Ramez, Xu, Hao, Vesely, Maria Carolina Amezcua, Soukou, Shiwa, Steglich, Babett, Bedke, Tanja, Manthey, Carolin, Seiz, Oliver, Diercks, Björn-Philipp, Gnafakis, Stylianos, Guse, Andreas H., Perez, Daniel, Izbicki, Jakob R., Gagliani, Nicola, Flavell, Richard A., Huber, Samuel

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Mag-Fluo4 in T cells: Imaging of intra-organelle free Ca2+ concentrations by Diercks, Björn-Philipp, Fliegert, Ralf, Guse, Andreas H.

“…Ca2+ signaling is a major signal transduction pathway involved in T cell activation, but also in apoptosis of T cells. Since T cells make use of several…”
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