Search Results - "Diep, Vivian K."
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High Interferon Signature Leads to Increased STAT1/3/5 Phosphorylation in PBMCs From SLE Patients by Single Cell Mass Cytometry
Published in Frontiers in immunology (28-01-2022)“…The establishment of an "interferon (IFN) signature" to subset SLE patients on disease severity has led to therapeutics targeting IFNα. Here, we investigate…”
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Integrated, multicohort analysis reveals unified signature of systemic lupus erythematosus
Published in JCI insight (27-02-2020)“…Systemic lupus erythematosus (SLE) is a complex autoimmune disease that follows an unpredictable disease course and affects multiple organs and tissues. We…”
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Autoantigen microarrays reveal autoantibodies associated with proliferative nephritis and active disease in pediatric systemic lupus erythematosus
Published in Arthritis research & therapy (17-06-2015)“…Pediatric systemic lupus erythematosus (pSLE) patients often initially present with more active and severe disease than adults, including a higher frequency of…”
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High-Resolution Analysis of Antibodies to Post-Translational Modifications Using Peptide Nanosensor Microarrays
Published in ACS nano (27-12-2016)“…Autoantibodies are a hallmark of autoimmune diseases such as lupus and have the potential to be used as biomarkers for diverse diseases, including…”
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Multiplex giant magnetoresistive biosensor microarrays identify interferon-associated autoantibodies in systemic lupus erythematosus
Published in Scientific reports (09-06-2016)“…High titer, class-switched autoantibodies are a hallmark of systemic lupus erythematosus (SLE). Dysregulation of the interferon (IFN) pathway is observed in…”
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Mapping epitopes of U1-70K autoantibodies at single-amino acid resolution
Published in Autoimmunity (Chur, Switzerland) (17-11-2015)“…The mechanisms underlying development of ribonucleoprotein (RNP) autoantibodies are unclear. The U1-70K protein is the predominant target of RNP…”
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