Search Results - "Diener, John L."

FGF21 Normalizes Plasma Glucose in Mouse Models of Type 1 Diabetes and Insulin Receptor Dysfunction by Diener, John L, Mowbray, Sarah, Huang, Waan-Jeng, Yowe, David, Xu, Jian, Caplan, Shari, Misra, Abhay, Kapur, Ankur, Shapiro, Jeffrey, Ke, Xiaoling, Wu, Xiaoping, Bose, Avirup, Panza, Darrell, Chen, Min, Beaulieu, Valerie, Gao, Jiaping

“…Fibroblast growth factor (FGF) 21 is a member of the FGF family of proteins. The biological activity of FGF21 was first shown to induce insulin-independent…”
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A Structural Explanation for the Antithrombotic Activity of ARC1172, a DNA Aptamer that Binds von Willebrand Factor Domain A1 by Huang, Ren-Huai, Fremont, Daved H., Diener, John L., Schaub, Robert G., Sadler, J. Evan

“…ARC1172 is a 41-mer DNA aptamer selected to bind the A1 domain of von Willebrand factor (VWF). A derivative of ARC1172 with modifications to increase…”
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Solution Structure of a Substrate for the Archaeal Pre-tRNA Splicing Endonucleases: The Bulge-Helix-Bulge Motif by Diener, John L, Moore, Peter B

“…The structure of the bulge-helix-bulge motif that constitutes the intron/exon splice site in H. volcanii pre-tRNA Trp has been determined by NMR spectroscopy…”
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Blood Pressure-Associated Genetic Variants in the Natriuretic Peptide Receptor 1 Gene Modulate Guanylate Cyclase Activity by Vandenwijngaert, Sara, Ledsky, Clara D, Lahrouchi, Najim, Khan, Mohsin A F, Wunderer, Florian, Ames, Lisa, Honda, Toshiyuki, Diener, John L, Bezzina, Connie R, Buys, Emmanuel S, Bloch, Donald B, Newton-Cheh, Christopher

“…Human genetic variation in the NPR1 (natriuretic peptide receptor 1 gene, encoding NPR-A, atrial natriuretic peptide receptor 1) was recently shown to affect…”
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Role of SRP19 in Assembly of the Archaeoglobus fulgidus Signal Recognition Particle by Diener, John L, Wilson, Charles

“…Previous studies have shown that SRP19 promotes association of the highly conserved signal peptide-binding protein, SRP54, with the signal recognition particle…”
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A novel strategy for selection of allosteric ribozymes yields RiboReporter™ sensors for caffeine and aspartame by Ferguson, Alicia, Boomer, Ryan M., Kurz, Markus, Keene, Sara C., Diener, John L., Keefe, Anthony D., Wilson, Charles, Cload, Sharon T.

“…We have utilized in vitro selection technology to develop allosteric ribozyme sensors that are specific for the small molecule analytes caffeine or aspartame…”
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Complex conformations and crystal contacts by Diener, John L

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ADP-Specific Sensors Enable Universal Assay of Protein Kinase Activity by Srinivasan, Jayaram, Cload, Sharon T, Hamaguchi, Nobuko, Kurz, Jeffrey, Keene, Sara, Kurz, Markus, Boomer, Ryan M, Blanchard, Jill, Epstein, David, Wilson, Charles, Diener, John L

“…Two molecular sensors that specifically recognize ADP in a background of over 100-fold molar excess of ATP are described. These sensors are nucleic-acid based…”
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Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with Aptamer ARC1172, An Inhibitor of VWF-Platelet Binding by Huang, Ren-Huai, Fremont, David, Tuley, Elodee A, Diener, John L, Schaub, Robert G, Sadler, J. Evan

“…ARC1779 is a modified 40-mer oligonucleotide aptamer that binds with high affinity to the VWF A1 domain and blocks VWF binding to platelet GPIb-alpha. When…”
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Discovery, Engineering and Pre-Clinical Evaluation of an Anti-vWF A1 Domain Aptamer by Diener, John L., Lagasse, H.A. Daniel, Gilbert, Madaline, Merlino, Patricia, Killough, Jason, Marsh, H. Nicholas, Boomer, Ryan M., Fraone, Joseph M., McCauley, Thomas, Makim, Ankit, Lewis, Scott D., Cai, Larry, Hutabarat, Renta, Rottman, James B., Benedict, Claude, Fontana, David

“…Following coronary artery damage, von Willebrand Factor (vWF) multimers adhere to exposed collagen via the vWF A3 domain. Platelets passing through damaged…”
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A novel strategy for selection of allosteric ribozymes yields RiboReporter registered sensors for caffeine and aspartame by Ferguson, Alicia, Boomer, Ryan M, Kurz, Markus, Keene, Sara C, Diener, John L, Keefe, Anthony D, Wilson, Charles, Cload, Sharon T

“…We have utilized in vitro selection technology to develop allosteric ribozyme sensors that are specific for the small molecule analytes caffeine or aspartame…”
Get full text