Additive Manufacturing of Bioactive Poly(trimethylene carbonate)/β-Tricalcium Phosphate Composites for Bone Regeneration

Additive Manufacturing of Bioactive Poly(trimethylene carbonate)/β-Tricalcium Phosphate Composites for Bone Regeneration

Implants of bioresorbable materials combined with osteoconductive calcium phosphate ceramics show promising results to replace and repair damaged bone tissue. Here we present additive manufacturing of patient-specific porous scaffolds of poly­(trimethylene carbonate) (PTMC) including high amounts of...

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Bibliographic Details
Published in:Biomacromolecules Vol. 21; no. 2; pp. 366 - 375
Main Authors: Dienel, Kasper E. G, van Bochove, Bas, Seppälä, Jukka V
Format: Journal Article
Language:English
Published: United States American Chemical Society 10-02-2020
Subjects:
Bone Regeneration
Calcium Phosphates - chemistry
Calorimetry, Differential Scanning
Dioxanes - chemistry
Materials Testing
Polymerization
Polymers - chemistry
Porosity
Stereolithography
Tensile Strength
Thermogravimetry
Tissue Scaffolds - chemistry
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Summary:Implants of bioresorbable materials combined with osteoconductive calcium phosphate ceramics show promising results to replace and repair damaged bone tissue. Here we present additive manufacturing of patient-specific porous scaffolds of poly­(trimethylene carbonate) (PTMC) including high amounts of β-tricalcium phosphate (β-TCP). Tensile testing of composite networks showed that addition of β-tricalcium phosphate reinforces the composites significantly. Three-dimensional structures containing up to 60 wt % β-TCP could be built by stereolithography. By lowering the content to 51 wt %, manufacturing of a large-sized patient-specific prototype was possible at high resolution. Closer examination revealed that the created scaffolds contained more β-TCP on the surface of the builds. Stereolithography therefore provides a manufacturing technique where the bioactive agent is directly available for creating an enhanced microenvironment for cell growth. The biocompatibility and bioresorption of PTMC coupled with the osteoconductivity of β-TCP are an important candidate to consider in additive manufacturing of bone regeneration implants.
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ISSN:1525-7797
1526-4602
DOI:10.1021/acs.biomac.9b01272