Search Results - "Dienel, Gerald A"

Lack of appropriate stoichiometry: Strong evidence against an energetically important astrocyte–neuron lactate shuttle in brain by Dienel, Gerald A.

“…Glutamate‐stimulated aerobic glycolysis in astrocytes coupled with lactate shuttling to neurons where it can be oxidized was proposed as a mechanism to couple…”
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Brain Lactate Metabolism: The Discoveries and the Controversies by Dienel, Gerald A

“…Potential roles for lactate in the energetics of brain activation have changed radically during the past three decades, shifting from waste product to…”
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Does shuttling of glycogen‐derived lactate from astrocytes to neurons take place during neurotransmission and memory consolidation? by Dienel, Gerald A.

“…Glycogen levels in resting brain and its utilization rates during brain activation are high, but the functions fulfilled by glycogenolysis in living brain are…”
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The metabolic trinity, glucose–glycogen–lactate, links astrocytes and neurons in brain energetics, signaling, memory, and gene expression by Dienel, Gerald A.

“…•Glucose, glycogen, and lactate are involved in diverse aspects of brain function.•Fate of surplus carbohydrate taken up into brain during exercise is…”
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Sugar for the brain: the role of glucose in physiological and pathological brain function by Mergenthaler, Philipp, Lindauer, Ute, Dienel, Gerald A, Meisel, Andreas

“…Highlights • We provide a comprehensive overview of the role of glucose metabolism in normal brain function. • We analyze the contribution of glucose…”
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Lactate Shuttling and Lactate use as Fuel after Traumatic Brain Injury: Metabolic Considerations by Dienel, Gerald A

“…Lactate is proposed to be generated by astrocytes during glutamatergic neurotransmission and shuttled to neurons as ‘preferred’ oxidative fuel. However, a…”
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Aerobic glycolysis during brain activation: adrenergic regulation and influence of norepinephrine on astrocytic metabolism by Dienel, Gerald A., Cruz, Nancy F.

“…Aerobic glycolysis occurs during brain activation and is characterized by preferential up‐regulation of glucose utilization compared with oxygen consumption…”
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Fueling and imaging brain activation by Dienel, Gerald A

“…Metabolic signals are used for imaging and spectroscopic studies of brain function and disease and to elucidate the cellular basis of neuroenergetics. The…”
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Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis glycogenolysis by Hertz, Leif, Peng, Liang, Dienel, Gerald A

“…Astrocytic energy demand is stimulated by K+ and glutamate uptake, signaling processes, responses to neurotransmitters, Ca2+ fluxes, and filopodial motility…”
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Brain Glucose Metabolism: Integration of Energetics with Function by Dienel, Gerald A

“…Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions, including ATP production, oxidative stress management, and…”
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Contributions of glycogen to astrocytic energetics during brain activation by Dienel, Gerald A., Cruz, Nancy F.

“…Glycogen is the major store of glucose in brain and is mainly in astrocytes. Brain glycogen levels in unstimulated, carefully-handled rats are 10–12 μmol/g,…”
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A dogma‐breaking concept: glutamate oxidation in astrocytes is the source of lactate during aerobic glycolysis in resting subjects by Dienel, Gerald A., McKenna, Mary C.

“…Read the full article ‘Glutamate synthesis has to be matched by its degradation–where do all the carbons go?’ on doi: 10.1111/jnc.12812…”
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Cellular Origin of [18F]FDG-PET Imaging Signals During Ceftriaxone-Stimulated Glutamate Uptake: Astrocytes and Neurons by Dienel, Gerald A., Behar, Kevin L., Rothman, Douglas L.

“…Ceftriaxone stimulates astrocytic uptake of the excitatory neurotransmitter glutamate, and it is used to treat glutamatergic excitotoxicity that becomes…”
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Astrocytic contributions to bioenergetics of cerebral ischemia by Dienel, Gerald A., Hertz, Leif

“…Astrocytes are multifunctional cells that interact with neurons and other astrocytes in signaling and metabolic functions, and their resistance to…”
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Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices by Takano, Takahiro, He, Wei, Han, Xiaoning, Wang, Fushun, Xu, Qiwu, Wang, Xiaohai, Oberheim Bush, Nancy Ann, Cruz, Nancy, Dienel, Gerald A., Nedergaard, Maiken

“…A flurry of studies over the past decade has shown that astrocytes play a more active role in neural function than previously recognized. Hippocampal slices…”
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glycogen phosphorylase inhibitor selectively enhances local rates of glucose utilization in brain during sensory stimulation of conscious rats: implications for glycogen turnover by Dienel, Gerald A, Ball, Kelly K, Cruz, Nancy F

“…Glycogen is degraded during brain activation but its role and contribution to functional energetics in normal activated brain have not been established. In the…”
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Astrocytes are 'good scouts': being prepared also helps neighboring neurons by Dienel, Gerald A

“…Recognition of glycogen as an active participant in the energetics of brain activation is replacing the long-held concept of glycogen as an emergency energy…”
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Stop the rot. Enzyme inactivation at brain harvest prevents artifacts: A guide for preservation of the in vivo concentrations of brain constituents by Dienel, Gerald A

“…Post-mortem metabolism is widely recognized to cause rapid and prolonged changes in the concentrations of multiple classes of compounds in brain, that is, they…”
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Metabolomic and Imaging Mass Spectrometric Assays of Labile Brain Metabolites: Critical Importance of Brain Harvest Procedures by Dienel, Gerald A.

“…Metabolomic technologies including imaging mass spectrometry (IMS; also called mass spectrometry imaging, MSI, or matrix-assisted laser…”
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Reduced gap junctional communication among astrocytes in experimental diabetes: Contributions of altered connexin protein levels and oxidative-nitrosative modifications by Ball, Kelly K., Harik, Lamia, Gandhi, Gautam K., Cruz, Nancy F., Dienel, Gerald A.

“…Experimental diabetes increases production of reactive oxygen–nitrogen species and inhibits astrocytic gap junctional communication in tissue culture and brain…”
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