Correlations of Serum Lipid Parameters and Atherogenic Indices With Left Ventricular Diastolic Dysfunction Among Apparently Healthy Patients With Type 2 Diabetes Mellitus: A Multicenter In-Hospital Cross-Sectional Study

In adolescents with Type 1 diabetes, lipid ratios are predictors of left ventricular diastolic dysfunction (LVDD). However, whether this also applies to adults with Type 2 Diabetes Mellitus (T2DM) is unclear. This study is aimed at assessing the correlations of serum lipid parameters and atherogenic...

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Published in:	Journal of diabetes research Vol. 2024; no. 1; p. 4078281
Main Authors:	Dienda, Yves Mayambu, On'kin, Jean-Bosco Kasiam Lasi, Natuhoyila, Aliocha Nkodila, Lubenga, Yves, Swambulu, Tresor Mvunzi, M'buyamba-Kabangu, Jean-René, Longo-Mbenza, Benjamin, Phanzu, Bernard Kianu
Format:	Journal Article
Language:	English
Published:	England Hindawi Limited 2024
Subjects:	Abdomen Adult Aged Alcohol use Atherosclerosis - blood Atherosclerosis - epidemiology Atherosclerosis - physiopathology Blood Glucose - analysis Blood Glucose - metabolism Cardiomyopathy Cardiovascular disease Cholesterol Cholesterol, HDL - blood Chronic illnesses Cross-Sectional Studies Diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - physiopathology Diastole Drug use Echocardiography Female Glycated Hemoglobin - analysis Glycated Hemoglobin - metabolism Health care Heart failure High density lipoprotein Hormone replacement therapy Humans Hypertension Ischemia Kidney diseases Lipids Lipids - blood Male Medical history Metabolic disorders Middle Aged Obesity Patients Ratios Regression analysis Risk Factors Smoking Triglycerides - blood Ventricular Dysfunction, Left - blood Ventricular Dysfunction, Left - epidemiology Ventricular Dysfunction, Left - physiopathology
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Summary:	In adolescents with Type 1 diabetes, lipid ratios are predictors of left ventricular diastolic dysfunction (LVDD). However, whether this also applies to adults with Type 2 Diabetes Mellitus (T2DM) is unclear. This study is aimed at assessing the correlations of serum lipid parameters and atherogenic indices with LVDD in patients with T2DM. This cross-sectional study included 203 patients with T2DM aged 59.9 ± 13.6 years (111 males, sex ratio: 1 : 2 in favor of males) from eight randomly selected urban hospitals. Demographic information was collected, an anthropometric assessment was performed, and blood pressure was measured. Fasting blood samples were obtained to assess total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TGs), glucose, and glycated hemoglobin. The atherogenic index of plasma (AIP), Castelli Risk Index I (CRI-I), Castelli Risk Index II (CRI-II), atherogenic coefficient, and non-HDL-C were determined using specific formulas. Diastolic function was assessed using echocardiography as per the 2016 updated guidelines of the American Society of Echocardiography (ASE) and the European Association of Cardiovascular Imaging (EACVI). Approximately 47.8% of the participants had LVDD. Compared with participants with normal diastolic function, those with LVDD were more likely to be older than 55 years ( < 0.001), tended to have obesity ( = 0.045), had a higher risk of developing dyslipidemia ( = 0.041), and higher AIP and CRI-II ( < 0.05) levels while having similar low HDL-C and hypertriglyceridemia frequencies. In the multivariate model adjusting for age, high AIP (adjusted odds ratio [aOR], 3.37; 95% confidence interval [CI], 1.22-5.34) and high CRI-II (aOR: 3.80; 95% CI: 2.25-6.35) were independent determinants of LVDD. These results highlight the importance of considering atherogenic indices, primarily AIP and CRI-II in the management of T2DM patients. High AIP and high CRI-II could serve as surrogate markers of LVDD, an early cardiovascular manifestation in patients with T2DM.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2314-6745 2314-6753 2314-6753
DOI:	10.1155/2024/4078281