Search Results - "Diem, Michael"

PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs by Dreyfuss, Gideon, Diem, Michael D, Chan, Chia C, Younis, Ihab

“…Messenger RNAs produced by splicing are translated more efficiently than those produced from similar intronless precursor mRNAs (pre-mRNAs). The exon-junction…”
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"Stapling" scFv for multispecific biotherapeutics of superior properties by Boucher, Lauren E, Prinslow, Elisabeth Geyer, Feldkamp, Michael, Yi, Fang, Nanjunda, Rupesh, Wu, Sheng-Jiun, Liu, Tun, Lacy, Eilyn R, Jacobs, Steven, Kozlyuk, Natalia, Del Rosario, Brian, Wu, Bingyuan, Aquino, Patricia, Davidson, Robert C, Heyne, Samantha, Mazzanti, Nicholas, Testa, James, Diem, Michael D, Gorre, Elsa, Mahan, Andrew, Nanda, Hirsh, Gunawardena, Harsha P, Gervais, Alexis, Armstrong, Anthony A, Teplyakov, Alexey, Huang, Chichi, Zwolak, Adam, Chowdhury, Partha, Cheung, Wan Cheung, Luo, Jinquan

“…Single-chain fragment variable (scFv) domains play an important role in antibody-based therapeutic modalities, such as bispecifics, multispecifics and chimeric…”
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Selection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop positions by Diem, Michael D., Hyun, Linus, Yi, Fang, Hippensteel, Randi, Kuhar, Elise, Lowenstein, Cassandra, Swift, Edward J., O'Neil, Karyn T., Jacobs, Steven A.

“…Alternative scaffold molecules represent a class of proteins important to the study of protein design and mechanisms of protein–protein interactions, as well…”
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A Quantitative High-Throughput In Vitro Splicing Assay Identifies Inhibitors of Spliceosome Catalysis by Berg, Michael G., Wan, Lili, Younis, Ihab, Diem, Michael D., Soo, Michael, Wang, Congli, Dreyfuss, Gideon

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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High-Throughput Generation of Bipod (Fab × scFv) Bispecific Antibodies Exploits Differential Chain Expression and Affinity Capture by Nesspor, Thomas C., Kinealy, Kyle, Mazzanti, Nicholas, Diem, Michael D., Boye, Kevin, Hoffman, Hunter, Springer, Christine, Sprenkle, Justin, Powers, Gordon, Jiang, Haiyan, La Porte, Sherry L., Ganesan, Rajkumar, Singh, Sanjaya, Zwolak, Adam

“…Generation of bispecific antibodies (BsAbs) having two unique Fab domains requires heterodimerization of the two heavy chains and pairing of each heavy chain…”
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eIF4A3 is a novel component of the exon junction complex by Chan, Chia C, Dostie, Josee, Diem, Michael D, Feng, Wenqin, Mann, Matthias, Rappsilber, Juri, Dreyfuss, Gideon

“…The exon junction complex (EJC) is a protein complex that assembles near exon-exon junctions of mRNAs as a result of splicing. EJC proteins play important…”
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Design of novel FN3 domains with high stability by a consensus sequence approach by Jacobs, Steven A., Diem, Michael D., Luo, Jinquan, Teplyakov, Alexey, Obmolova, Galina, Malia, Thomas, Gilliland, Gary L., O'Neil, Karyn T.

“…The use of consensus design to produce stable proteins has been applied to numerous structures and classes of proteins. Here, we describe the engineering of…”
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Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with spliced mRNA by Kataoka, Naoyuki, Diem, Michael D., Yoshida, Mayumi, Hatai, Chihiro, Dobashi, Izumi, Dreyfuss, Gideon, Hagiwara, Masatoshi, Ohno, Mutsuhito

“…Pre-mRNA splicing deposits multi-protein complexes, termed exon junction complexes (EJCs), on mRNAs near exon-exon junctions. The core of EJC consists of four…”
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Structure of the Y14-Magoh Core of the Exon Junction Complex by Lau, Chi-Kong, Diem, Michael D, Dreyfuss, Gideon, Van Duyne, Gregory D

“…Background: Splicing of pre-mRNA in eukaryotes imprints the resulting mRNA with a specific multiprotein complex, the exon-exon junction complex (EJC), at the…”
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Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex by Kataoka, Naoyuki, Diem, Michael D., Kim, V. Narry, Yong, Jeongsik, Dreyfuss, Gideon

“…The RNA‐binding protein Y14 binds preferentially to mRNAs produced by splicing and is a component of a multiprotein complex that assembles ∼20 nucleotides…”
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The Y14 protein communicates to the cytoplasm the position of exon-exon junctions by Kim, V.Narry, Yong, Jeongsik, Kataoka, Naoyuki, Abel, Linda, Diem, Michael D., Dreyfuss, Gideon

“…We recently described an RNA‐binding protein, Y14, that binds preferentially to spliced mRNAs and persists in the cytoplasm. Y14 is part of a multi‐protein…”
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Abstract 5662: JNJ-67571244: A novel anti-CD33 C2 domain binding bispecific antibody with potent T cell redirection activity by Nair-Gupta, Priyanka, Diem, Michael, Reeves, Dara, Wang, Weirong, Schulingkamp, Robert, Sproesser, Katrin, Mattson, Bethany, Heidrich, Bradley, Joseph, Jocelin, Sendecki, Jocelyn, Foulk, Brad, Chu, Gerald, Fink, Damien, Jiao, Qun, Wu, Sheng-Jiun, Packman, Kathryn, Elsayed, Yusri, Attar, Ricardo, Gaudet, Francois

“…Abstract CD33 is expressed in 90% of acute myeloid leukemia (AML) patients with expression in both blasts and leukemic stem cells. The extracellular portion of…”
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Solutions to the Battle of the Forms by Diem, Michael

“…When dealing with commercial transactions in today’s day and age, it is common practice for the parties involved to communicate with one another through the…”
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A novel C2 domain binding CD33xCD3 bispecific antibody with potent T-cell redirection activity against acute myeloid leukemia by Nair-Gupta, Priyanka, Diem, Michael, Reeves, Dara, Wang, Weirong, Schulingkamp, Robert, Sproesser, Katrin, Mattson, Bethany, Heidrich, Bradley, Mendonça, Mark, Joseph, Jocelin, Sendecki, Jocelyn, Foulk, Brad, Chu, Gerald, Fink, Damien, Jiao, Qun, Wu, Sheng-Jiun, Packman, Kathryn, Elsayed, Yusri, Attar, Ricardo, Gaudet, François

“…CD33 is expressed in 90% of patients with acute myeloid leukemia (AML), and its extracellular portion consists of a V domain and a C2 domain. A recent study…”
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Protein interactions among the components of the exon junction complex by Diem, Michael D

“…Throughout the lifecycle of an mRNA, a diverse, highly dynamic, and ever changing set of RNA bindings proteins are constantly interacting with the mRNA. Most…”
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"Stapling" scFv for multispecific biotherapeutics of superior properties by Boucher, Lauren E., Prinslow, Elisabeth Geyer, Feldkamp, Michael, Yi, Fang, Nanjunda, Rupesh, Wu, Sheng-Jiun, Liu, Tun, Lacy, Eilyn R., Jacobs, Steven, Kozlyuk, Natalia, Del Rosario, Brian, Wu, Bingyuan, Aquino, Patricia, Davidson, Robert C., Heyne, Samantha, Mazzanti, Nicholas, Testa, James, Diem, Michael D., Gorre, Elsa, Mahan, Andrew, Nanda, Hirsh, Gunawardena, Harsha P., Gervais, Alexis, Armstrong, Anthony A., Teplyakov, Alexey, Huang, Chichi, Zwolak, Adam, Chowdhury, Partha, Cheung, Wan Cheung, Luo, Jinquan

“…Single-chain fragment variable (scFv) domains play an important role in antibody-based therapeutic modalities, such as bispecifics, multispecifics and chimeric…”
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PHOTOCHEMICAL REACTIONS OF FORMALDEHYDE AND GLYOXAL IN LOW-TEMPERATURE MATRICES by DIEM, MICHAEL

“…Samples of formaldehyde and glyoxal were photolyzed in low-temperature Ar and O(,2) matrices, using Hg lamp and laser light sources. Reactions were monitored…”
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Modernes Messdatenmanagement im Flottenbetrieb by Diem, Michael

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Photooxidation of formaldehyde in solid oxygen and argon/oxygen matrixes at 12 K by Diem, Michael, Lee, Edward K. C

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Photolysis and laser-excited fluorescence and phosphorescence emission of trans-glyoxal in an argon matrix at 13 K by Diem, Michael, MacDonald, Bruce G, Lee, Edward K. C

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