Search Results - "Diekman, Casey O."

Circadian Rhythms of Early Afterdepolarizations and Ventricular Arrhythmias in a Cardiomyocyte Model by Diekman, Casey O., Wei, Ning

“…Sudden cardiac arrest is a malfunction of the heart’s electrical system, typically caused by ventricular arrhythmias, that can lead to sudden cardiac death…”
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A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability by Flourakis, Matthieu, Kula-Eversole, Elzbieta, Hutchison, Alan L., Han, Tae Hee, Aranda, Kimberly, Moose, Devon L., White, Kevin P., Dinner, Aaron R., Lear, Bridget C., Ren, Dejian, Diekman, Casey O., Raman, Indira M., Allada, Ravi

“…Circadian clocks regulate membrane excitability in master pacemaker neurons to control daily rhythms of sleep and wake. Here, we find that two distinctly timed…”
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Daily electrical activity in the master circadian clock of a diurnal mammal by Bano-Otalora, Beatriz, Moye, Matthew J, Brown, Timothy, Lucas, Robert J, Diekman, Casey O, Belle, Mino Dc

“…Circadian rhythms in mammals are orchestrated by a central clock within the suprachiasmatic nuclei (SCN). Our understanding of the electrophysiological basis…”
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Daily Electrical Silencing in the Mammalian Circadian Clock by Belle, Mino D.C, Diekman, Casey O, Forger, Daniel B, Piggins, Hugh D

“…Neurons in the brain's suprachiasmatic nuclei (SCNs), which control the timing of daily rhythms, are thought to encode time of day by changing their firing…”
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Modeling the Neuroprotective Role of Enhanced Astrocyte Mitochondrial Metabolism during Stroke by Diekman, Casey O., Fall, Christopher P., Lechleiter, James D., Terman, David

“…A mathematical model that integrates the dynamics of cell membrane potential, ion homeostasis, cell volume, mitochondrial ATP production, mitochondrial and…”
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Causes and consequences of hyperexcitation in central clock neurons by Diekman, Casey O, Belle, Mino D C, Irwin, Robert P, Allen, Charles N, Piggins, Hugh D, Forger, Daniel B

“…Hyperexcited states, including depolarization block and depolarized low amplitude membrane oscillations (DLAMOs), have been observed in neurons of the…”
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Computational Neuroscience: Mathematical and Statistical Perspectives by Kass, Robert E, Amari, Shun-Ichi, Arai, Kensuke, Brown, Emery N, Diekman, Casey O, Diesmann, Markus, Doiron, Brent, Eden, Uri T, Fairhall, Adrienne L, Fiddyment, Grant M, Fukai, Tomoki, Grün, Sonja, Harrison, Matthew T, Helias, Moritz, Nakahara, Hiroyuki, Teramae, Jun-nosuke, Thomas, Peter J, Reimers, Mark, Rodu, Jordan, Rotstein, Horacio G, Shea-Brown, Eric, Shimazaki, Hideaki, Shinomoto, Shigeru, Yu, Byron M, Kramer, Mark A

“…Mathematical and statistical models have played important roles in neuroscience, especially by describing the electrical activity of neurons recorded…”
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Reentrainment of the circadian pacemaker during jet lag: East-west asymmetry and the effects of north-south travel by Diekman, Casey O., Bose, Amitabha

“…•We use a mathematical model of the human circadian clock to study jet lag.•Jet lag severity depends on the traveler’s internal clock and the season of the…”
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Beyond the limits of circadian entrainment: Non-24-h sleep-wake disorder, shift work, and social jet lag by Diekman, Casey O., Bose, Amitabha

“…•We use a mathematical model to study entrainment of the human circadian clock.•Entrainment maps are developed to analyze scenarios where the clock is…”
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COVID-19 and silent hypoxemia in a minimal closed-loop model of the respiratory rhythm generator by Diekman, Casey O., Thomas, Peter J., Wilson, Christopher G.

“…Silent hypoxemia, or “happy hypoxia,” is a puzzling phenomenon in which patients who have contracted COVID-19 exhibit very low oxygen saturation ( SaO 2 < 80%)…”
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Neuronal oscillations on an ultra‐slow timescale: daily rhythms in electrical activity and gene expression in the mammalian master circadian clockwork by Belle, Mino D. C., Diekman, Casey O.

“…Neuronal oscillations of the brain, such as those observed in the cortices and hippocampi of behaving animals and humans, span across wide frequency bands,…”
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Entrainment Maps: A New Tool for Understanding Properties of Circadian Oscillator Models by Diekman, Casey O., Bose, Amitabha

“…Circadian oscillators found across a variety of species are subject to periodic external light-dark forcing. Entrainment to light-dark cycles enables the…”
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Eupnea, tachypnea, and autoresuscitation in a closed-loop respiratory control model by Diekman, Casey O, Thomas, Peter J, Wilson, Christopher G

“…How sensory information influences the dynamics of rhythm generation varies across systems, and general principles for understanding this aspect of motor…”
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The E3 ubiquitin ligase adaptor Tango10 links the core circadian clock to neuropeptide and behavioral rhythms by Lee, Jongbin, Lim, Chunghun, Han, Tae Hee, Andreani, Tomas, Moye, Matthew, Curran, Jack, Johnson, Eric, Kath, William L., Diekman, Casey O., Lear, Bridget C., Allada, Ravi

“…Circadian transcriptional timekeepers in pacemaker neurons drive profound daily rhythms in sleep and wake. Here we reveal a molecular pathway that links core…”
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Inferring Parameters of Pyramidal Neuron Excitability in Mouse Models of Alzheimer’s Disease Using Biophysical Modeling and Deep Learning by Saghafi, Soheil, Rumbell, Timothy, Gurev, Viatcheslav, Kozloski, James, Tamagnini, Francesco, Wedgwood, Kyle C. A., Diekman, Casey O.

“…Alzheimer’s disease (AD) is believed to occur when abnormal amounts of the proteins amyloid beta and tau aggregate in the brain, resulting in a progressive…”
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Data Assimilation Methods for Neuronal State and Parameter Estimation by Moye, Matthew J., Diekman, Casey O.

“…This tutorial illustrates the use of data assimilation algorithms to estimate unobserved variables and unknown parameters of conductance-based neuronal models…”
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CikA, an Input Pathway Component, Senses the Oxidized Quinone Signal to Generate Phase Delays in the Cyanobacterial Circadian Clock by Kim, Pyonghwa, Porr, Brianna, Mori, Tetsuya, Kim, Yong-Sung, Johnson, Carl H., Diekman, Casey O., Kim, Yong-Ick

“…The circadian clock is a timekeeping system in most organisms that keeps track of the time of day. The rhythm generated by the circadian oscillator must be…”
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Delayed Cryptochrome Degradation Asymmetrically Alters the Daily Rhythm in Suprachiasmatic Clock Neuron Excitability by Wegner, Sven, Belle, Mino D C, Hughes, Alun T L, Diekman, Casey O, Piggins, Hugh D

“…Suprachiasmatic nuclei (SCN) neurons contain an intracellular molecular circadian clock and the Cryptochromes (CRY1/2), key transcriptional repressors of this…”
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Entrainment Dynamics Organised by Global Manifolds in a Circadian Pacemaker Model by Creaser, Jennifer L., Diekman, Casey O., Wedgwood, Kyle C. A.

“…Circadian rhythms are established by the entrainment of our intrinsic body clock to periodic forcing signals provided by the external environment, primarily…”
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Clustering Predicted by an Electrophysiological Model of the Suprachiasmatic Nucleus by Diekman, Casey O, Forger, Daniel B

“…Despite the wealth of experimental data on the electrophysiology of individual neurons in the suprachiasmatic nuclei (SCN), the neural code of the SCN remains…”
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