Search Results - "Diefes, Kristin L."

Identification of Causal Genetic Drivers of Human Disease through Systems-Level Analysis of Regulatory Networks by Chen, James C., Alvarez, Mariano J., Talos, Flaminia, Dhruv, Harshil, Rieckhof, Gabrielle E., Iyer, Archana, Diefes, Kristin L., Aldape, Kenneth, Berens, Michael, Shen, Michael M., Califano, Andrea

“…Identification of driver mutations in human diseases is often limited by cohort size and availability of appropriate statistical models. We propose a framework…”
Get full text

The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma by Bhat, Krishna P L, Salazar, Katrina L, Balasubramaniyan, Veerakumar, Wani, Khalida, Heathcock, Lindsey, Hollingsworth, Faith, James, Johanna D, Gumin, Joy, Diefes, Kristin L, Kim, Se Hoon, Turski, Alice, Azodi, Yasaman, Yang, Yuhui, Doucette, Tiffany, Colman, Howard, Sulman, Erik P, Lang, Frederick F, Rao, Ganesh, Copray, Sjef, Vaillant, Brian D, Aldape, Kenneth D

“…Recent molecular classification of glioblastoma (GBM) has shown that patients with a mesenchymal (MES) gene expression signature exhibit poor overall survival…”
Get full text

Interlaboratory comparison of IDH mutation detection by van den Bent, Martin J., Hartmann, C., Preusser, Matthias, Ströbel, Thomas, Dubbink, Hendrikus J., Kros, Johan M., von Deimling, Andreas, Boisselier, Blandine, Sanson, Marc, Halling, Kevin C., Diefes, Kristin L., Aldape, Kenneth, Giannini, Caterina

“…Isocitrate dehydrogenase (IDH) mutational testing is becoming increasingly important. For this, robust and reliable assays are needed. We tested the variation…”
Get full text

Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients by Agnihotri, Sameer, Gajadhar, Aaron S, Ternamian, Christian, Gorlia, Thierry, Diefes, Kristin L, Mischel, Paul S, Kelly, Joanna, McGown, Gail, Thorncroft, Mary, Carlson, Brett L, Sarkaria, Jann N, Margison, Geoffrey P, Aldape, Kenneth, Hawkins, Cynthia, Hegi, Monika, Guha, Abhijit

“…Glioblastoma multiforme (GBM) is the most common and lethal of all gliomas. The current standard of care includes surgery followed by concomitant radiation and…”
Get full text

Identification of Causal Genetic Drivers of Human Disease through Systems-Level Analysis of Regulatory Networks by Chen, James C., Alvarez, Mariano J., Talos, Flaminia, Dhruv, Harshil, Rieckhof, Gabrielle E., Iyer, Archana, Diefes, Kristin L., Aldape, Kenneth, Berens, Michael, Shen, Michael M., Califano, Andrea

Get full text

Alkylpurine–DNA–N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients by Agnihotri, Sameer, Gajadhar, Aaron S., Ternamian, Christian, Gorlia, Thierry, Diefes, Kristin L., Mischel, Paul S., Kelly, Joanna, McGown, Gail, Thorncroft, Mary, Carlson, Brett L., Sarkaria, Jann N., Margison, Geoffrey P., Aldape, Kenneth, Hawkins, Cynthia, Hegi, Monika, Guha, Abhijit

Get full text