Search Results - "Diefenhardt, Markus"

Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer by Nicolas, Adele M., Pesic, Marina, Engel, Esther, Ziegler, Paul K., Diefenhardt, Markus, Kennel, Kilian B., Buettner, Florian, Conche, Claire, Petrocelli, Valentina, Elwakeel, Eiman, Weigert, Andreas, Zinoveva, Anna, Fleischmann, Maximilian, Häupl, Björn, Karakütük, Cem, Bohnenberger, Hanibal, Mosa, Mohammed H., Kaderali, Lars, Gaedcke, Jochen, Ghadimi, Michael, Rödel, Franz, Arkan, Melek C., Oellerich, Thomas, Rödel, Claus, Fokas, Emmanouil, Greten, Florian R.

“…Standard cancer therapy targets tumor cells without considering possible damage on the tumor microenvironment that could impair therapy response. In rectal…”
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Analysis of MRI and CT-based radiomics features for personalized treatment in locally advanced rectal cancer and external validation of published radiomics models by Shahzadi, Iram, Zwanenburg, Alex, Lattermann, Annika, Linge, Annett, Baldus, Christian, Peeken, Jan C., Combs, Stephanie E., Diefenhardt, Markus, Rödel, Claus, Kirste, Simon, Grosu, Anca-Ligia, Baumann, Michael, Krause, Mechthild, Troost, Esther G. C., Löck, Steffen

“…Radiomics analyses commonly apply imaging features of different complexity for the prediction of the endpoint of interest. However, the prognostic value of…”
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Acute toxicities of patients with locally advanced rectal cancer treated with intensified chemoradiotherapy within the CAO/ARO/AIO-12 trial: comparing conventional versus VMAT planning at a single center by Zimmermann, Marcus, Richter, Anne, Weick, Stefan, Exner, Florian, Mantel, Frederick, Diefenhardt, Markus, Fokas, Emmanouil, Kosmala, Rebekka, Flentje, Michael, Polat, Bülent

“…In locally advanced rectal cancer (LARC) neoadjuvant chemoradiotherapy is regarded as standard treatment. We assessed acute toxicities in patients receiving…”
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Leukocytosis and neutrophilia as independent prognostic immunological biomarkers for clinical outcome in the CAO/ARO/AIO‐04 randomized phase 3 rectal cancer trial by Diefenhardt, Markus, Hofheinz, Ralf‐Dieter, Martin, Daniel, Beißbarth, Tim, Arnold, Dirk, Hartmann, Arndt, Grün, Jens, Grützmann, Robert, Liersch, Torsten, Ströbel, Philipp, Grabenbauer, Gerhard G., Rieger, Michael, Fietkau, Rainer, Graeven, Ullrich, Weitz, Jürgen, Folprecht, Gunar, Ghadimi, Michael, Rödel, Franz, Rödel, Claus, Fokas, Emmanouil

“…Peripheral blood leukocytosis and neutrophilia reflect cancer inflammation and have been proposed as prognostic immunological biomarkers in various…”
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ACO/ARO/AIO-21 - Capecitabine-based chemoradiotherapy in combination with the IL-1 receptor antagonist anakinra for rectal cancer Patients: A phase I trial of the German rectal cancer study group by Fleischmann, Maximilian, Diefenhardt, Markus, Nicolas, Adele M., Rödel, Franz, Ghadimi, Michael, Hofheinz, Ralf-Dieter, Greten, Florian R., Rödel, Claus, Fokas, Emmanouil

“…•Response to chemoradiotherapy in rectal cancer is highly heterogeneous, ranging from complete response to tumor progression.•Interleukin-1 signaling polarizes…”
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Effects of iodinated contrast agent on HU-based dose calculation and dose delivered in iridium-192 high-dose-rate brachytherapy by Scherf, Christian, Ramm, Ulla, Stein, Thomas, Trommel, Martin, Tselis, Nikolaos, Chatzikonstantinou, Georgios, Diefenhardt, Markus, Rödel, Claus, Köhn, Janett, Licher, Jörg

“…This study compares the effect of iodinated contrast agent on Hounsfield unit (HU)-based TG-186 dose calculation vs. delivered dose for high-dose-rate (HDR)…”
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Individualized mould-based high-dose-rate brachytherapy for perinasal skin tumors: technique evaluation from a dosimetric point of view by Scherf, Christian, Licher, Jörg, Mletzko, Christina, Trommel, Martin, Tselis, Nikolaos, Chatzikonstantinou, Georgios, Diefenhardt, Markus, Rödel, Claus, Köhn, Janett, Ramm, Ulla

“…Dosimetric treatment planning evaluations concerning patient-adapted moulds for iridium-192 high-dose-rate brachytherapy are presented in this report. Six…”
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Association of Polo-Like Kinase 3 and PhosphoT273 Caspase 8 Levels With Disease-Related Outcomes Among Cervical Squamous Cell Carcinoma Patients Treated With Chemoradiation and Brachytherapy by Fleischmann, Max, Martin, Daniel, Peña-Llopis, Samuel, Oppermann, Julius, von der Grün, Jens, Diefenhardt, Markus, Chatzikonstantinou, Georgios, Fokas, Emmanouil, Rödel, Claus, Strebhardt, Klaus, Becker, Sven, Rödel, Franz, Tselis, Nikolaos

“…Definitive chemoradiation (CRT) followed by high-dose-rate (HDR) brachytherapy (BT) represents state-of-the-art treatment for locally-advanced cervical cancer…”
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Eine Monotherapie mit Immuncheckpointblockade führt bei Patienten mit Rektumkarzinom und Mikrosatelliteninstabilität zur klinischen Komplettremission by Diefenhardt, Markus, Fokas, Emmanouil, Rödel, Claus

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1150: Final Results of the CAO/ARO/AIO-12 trial – A Generalized Pairwise Comparison by Diefenhardt, Markus, Martin, Daniel, Hofheinz, Ralf-Dieter, Ghadimi, Michael, Rödel, Claus, Fleischmann, Maximilian, Fokas, Emmanouil

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322: Significance of persistent lymph node metastase after neoadjuvant chemoradiotherapy in rectal cancer by Diefenhardt, Markus, Martin, Daniel, Hofheinz, Ralf-Dieter, Ghadimi, Michael, Fokas, Emmanouil, Rödel, Claus, Fleischmann, Maximilian

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Monotherapy with immune checkpoint blockade leads to clinical complete remission in patients with rectal cancer and microsatellite instability by Diefenhardt, Markus, Fokas, Emmanouil, Rödel, Claus

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Image-guided high-dose-rate brachytherapy for rectal cancer: technical note and first clinical experience on an organ-preserving approach by Fleischmann, Maximilian, Diefenhardt, Markus, Trommel, Martin, Scherf, Christian, Ramm, Ulla, Chatzikonstantinou, Georgios, Fokas, Emmanouil, Rödel, Claus, Tselis, Nikolaos

“…Purpose As the population ages, the incidence of rectal cancer among elderly patients is rising. Due to the risk of perioperative morbidity and mortality,…”
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Tumor Response and Its Impact on Treatment Failure in Rectal Cancer: Does Intensity of Neoadjuvant Treatment Matter? by Diefenhardt, Markus, Martin, Daniel, Fleischmann, Maximilian, Hofheinz, Ralf-Dieter, Ghadimi, Michael, Rödel, Claus, Fokas, Emmanouil

“…Objectives: Additional adjuvant treatment in patients with rectal cancer with limited response to neoadjuvant treatment to mitigate their higher risk of…”
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2994: Neoadjuvant Chemoradiation for Oral Squamous Cell Carcinoma: The Prospective Phase II INVERT Trial by Fleischmann, Maximilian, Kristen, Alexander, Thönissen, Philipp, Winkelmann, Ria, Burck, Iris, Issing, Christian, Diefenhardt, Markus, Martin, Daniel, Brandts, Christian, Weigert, Andreas, Rödel, Franz, Ghanaati, Sharam, Balermpas, Panagiotis, Grün, Jens von der, Rödel, Claus

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Clinical outcome after total neoadjuvant treatment (CAO/ARO/AIO-12) versus intensified neoadjuvant and adjuvant treatment (CAO/ARO/AIO-04) a comparison between two multicenter randomized phase II/III trials by Diefenhardt, Markus, Fleischmann, Maximillian, Martin, Daniel, Hofheinz, Ralf-Dieter, Piso, Pompiliu, Germer, Christoph-Thomas, Hambsch, Peter, Grützmann, Robert, Kirste, Simon, Schlenska-Lange, Anke, Ghadimi, Michael, Rödel, Claus, Fokas, Emmanouil

“…•Intertrial comparison between intensified neoadjuvant chemoradiotherapy and adjuvant chemotherapy (CAO/ARO/AIO-04) vs Total Neoadjuvant Therapy…”
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Impact of body-mass index on treatment and outcome in locally advanced rectal cancer: A secondary, post-hoc analysis of the CAO/ARO/AIO-04 randomized phase III trial by Diefenhardt, Markus, Ludmir, Ethan B., Hofheinz, Ralf-Dieter, Ghadimi, Michael, Minsky, Bruce D., Fleischmann, Max, Fokas, Emmanouil, Rödel, Claus

“…•Obesity was linked to a lower rate of sphincter preservation surgery in rectal cancer after neoadjuvant chemoradiotherapy.•Incidence of post-surgical…”
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Advances in molecular targeted therapies to increase efficacy of (chemo)radiation therapy by Viktorsson, Kristina, Rieckmann, Thorsten, Fleischmann, Maximilian, Diefenhardt, Markus, Hehlgans, Stephanie, Rödel, Franz

“…Recent advances in understanding the tumor’s biology in line with a constantly growing number of innovative technologies have prompted characterization of…”
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Eine Monotherapie mit Immuncheckpointblockade führt bei Patienten mit Rektumkarzinom und Mikrosatelliteninstabilität zur klinischen Komplettremission by Diefenhardt, Markus, Fokas, Emmanouil, Rödel, Claus

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Progression-free survival is a suboptimal predictor for overall survival among metastatic solid tumour clinical trials by Pasalic, Dario, McGinnis, Gwendolyn J., Fuller, C. David, Grossberg, Aaron J., Verma, Vivek, Mainwaring, Walker, Miller, Austin B., Lin, Timothy A., Jethanandani, Amit, Espinoza, Andres F., Diefenhardt, Markus, Das, Prajnan, Subbiah, Vivek, Subbiah, Ishwaria M., Jagsi, Reshma, Garden, Adam S., Fokas, Emmanouil, Rödel, Claus, Thomas, Charles R., Minsky, Bruce D., Ludmir, Ethan B.

“…The use of overall survival (OS) as the gold standard primary end-point (PEP) in metastatic oncologic randomised controlled trials (RCTs) has declined in…”
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