Search Results - "Diederichs, Kay"

Dissecting random and systematic differences between noisy composite data sets by Diederichs, Kay

“…Composite data sets measured on different objects are usually affected by random errors, but may also be influenced by systematic (genuine) differences in the…”
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Linking Crystallographic Model and Data Quality by Karplus, P. Andrew, Diederichs, Kay

“…In macromolecular x-ray crystallography, refinement R values measure the agreement between observed and calculated data. Analogously, R merge values reporting…”
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Quantifying instrument errors in macromolecular X-ray data sets by Diederichs, Kay

“…An indicator which is calculated after the data reduction of a test data set may be used to estimate the (systematic) instrument error at a macromolecular…”
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Assessing and maximizing data quality in macromolecular crystallography by Karplus, P Andrew, Diederichs, Kay

“…•Common data quality indicators grouped as primary, secondary, or wrong/misleading.•A gedanken experiment reveals shortcomings of some common…”
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Breaking the indexing ambiguity in serial crystallography by Brehm, Wolfgang, Diederichs, Kay

“…In serial crystallography, a very incomplete partial data set is obtained from each diffraction experiment (a `snapshot'). In some space groups, an indexing…”
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Recent developments in CrystFEL by White, Thomas A., Mariani, Valerio, Brehm, Wolfgang, Yefanov, Oleksandr, Barty, Anton, Beyerlein, Kenneth R., Chervinskii, Fedor, Galli, Lorenzo, Gati, Cornelius, Nakane, Takanori, Tolstikova, Alexandra, Yamashita, Keitaro, Yoon, Chun Hong, Diederichs, Kay, Chapman, Henry N.

“…CrystFEL is a suite of programs for processing data from `serial crystallography' experiments, which are usually performed using X‐ray free‐electron lasers…”
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Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser by Kang, Yanyong, Zhou, X. Edward, Gao, Xiang, He, Yuanzheng, Liu, Wei, Ishchenko, Andrii, Barty, Anton, White, Thomas A., Yefanov, Oleksandr, Han, Gye Won, Xu, Qingping, de Waal, Parker W., Ke, Jiyuan, Tan, M. H. Eileen, Zhang, Chenghai, Moeller, Arne, West, Graham M., Pascal, Bruce D., Van Eps, Ned, Caro, Lydia N., Vishnivetskiy, Sergey A., Lee, Regina J., Suino-Powell, Kelly M., Gu, Xin, Pal, Kuntal, Ma, Jinming, Zhi, Xiaoyong, Boutet, Sébastien, Williams, Garth J., Messerschmidt, Marc, Gati, Cornelius, Zatsepin, Nadia A., Wang, Dingjie, James, Daniel, Basu, Shibom, Roy-Chowdhury, Shatabdi, Conrad, Chelsie E., Coe, Jesse, Liu, Haiguang, Lisova, Stella, Kupitz, Christopher, Grotjohann, Ingo, Fromme, Raimund, Jiang, Yi, Tan, Minjia, Yang, Huaiyu, Li, Jun, Wang, Meitian, Zheng, Zhong, Li, Dianfan, Howe, Nicole, Zhao, Yingming, Standfuss, Jörg, Diederichs, Kay, Dong, Yuhui, Potter, Clinton S., Carragher, Bridget, Caffrey, Martin, Jiang, Hualiang, Chapman, Henry N., Spence, John C. H., Fromme, Petra, Weierstall, Uwe, Ernst, Oliver P., Katritch, Vsevolod, Gurevich, Vsevolod V., Griffin, Patrick R., Hubbell, Wayne L., Stevens, Raymond C., Cherezov, Vadim, Melcher, Karsten, Xu, H. Eric

“…G-protein-coupled receptors (GPCRs) signal primarily through G proteins or arrestins. Arrestin binding to GPCRs blocks G protein interaction and redirects…”
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Identification of rogue datasets in serial crystallography by Assmann, Greta, Brehm, Wolfgang, Diederichs, Kay

“…Advances in beamline optics, detectors and X‐ray sources allow new techniques of crystallographic data collection. In serial crystallography, a large number of…”
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Structure of the V. cholerae Na+-pumping NADH:quinone oxidoreductase by Steuber, Julia, Vohl, Georg, Casutt, Marco S., Vorburger, Thomas, Diederichs, Kay, Fritz, Günter

“…NADH oxidation in the respiratory chain is coupled to ion translocation across the membrane to build up an electrochemical gradient. The sodium-translocating…”
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Chemical Proteomics of the Tumor Suppressor Fhit Covalently Bound to the Cofactor Ap3A Elucidates Its Inhibitory Action on Translation by Herzog, Doreen, Jansen, Jasmin, Mißun, Maite, Diederichs, Kay, Stengel, Florian, Marx, Andreas

“…The tumor suppressor protein fragile histidine triad (Fhit) is known to be associated with genomic instability and apoptosis. The tumor-suppressive function of…”
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In meso in situ serial X-ray crystallography of soluble and membrane proteins by Huang, Chia-Ying, Olieric, Vincent, Ma, Pikyee, Panepucci, Ezequiel, Diederichs, Kay, Wang, Meitian, Caffrey, Martin

“…The lipid cubic phase (LCP) continues to grow in popularity as a medium in which to generate crystals of membrane (and soluble) proteins for high‐resolution…”
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Crystal structures of ternary complexes of archaeal B-family DNA polymerases by Kropp, Heike M, Betz, Karin, Wirth, Johannes, Diederichs, Kay, Marx, Andreas

“…Archaeal B-family polymerases drive biotechnology by accepting a wide substrate range of chemically modified nucleotides. By now no structural data for…”
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Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop by Eicher, Thomas, Cha, Hi-jea, Seeger, Markus A, Brandstätter, Lorenz, El-Delik, Jasmin, Bohnert, Jürgen A, Kern, Winfried V, Verrey, François, Grütter, Markus G, Diederichs, Kay, Pos, Klaas M

“…AcrAB-TolC is the major efflux protein complex in Escherichia coli extruding a vast variety of antimicrobial agents from the cell. The inner membrane component…”
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Fast and accurate data collection for macromolecular crystallography using the JUNGFRAU detector by Leonarski, Filip, Redford, Sophie, Mozzanica, Aldo, Lopez-Cuenca, Carlos, Panepucci, Ezequiel, Nass, Karol, Ozerov, Dmitry, Vera, Laura, Olieric, Vincent, Buntschu, Dominik, Schneider, Roman, Tinti, Gemma, Froejdh, Erik, Diederichs, Kay, Bunk, Oliver, Schmitt, Bernd, Wang, Meitian

“…The accuracy of X-ray diffraction data is directly related to how the X-ray detector records photons. Here we describe the application of a direct-detection…”
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Chemoproteomic discovery of a human RNA ligase by Yuan, Yizhi, Stumpf, Florian M., Schlor, Lisa A., Schmidt, Olivia P., Saumer, Philip, Huber, Luisa B., Frese, Matthias, Höllmüller, Eva, Scheffner, Martin, Stengel, Florian, Diederichs, Kay, Marx, Andreas

“…RNA ligases are present across all forms of life. While enzymatic RNA ligation between 5′-PO 4 and 3′-OH termini is prevalent in viruses, fungi, and plants,…”
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Structural and Kinetic Analysis of Bacillus subtilis N-Acetylglucosaminidase Reveals a Unique Asp-His Dyad Mechanism by Litzinger, Silke, Fischer, Stefanie, Polzer, Patrick, Diederichs, Kay, Welte, Wolfram, Mayer, Christoph

“…Three-dimensional structures of NagZ of Bacillus subtilis, the first structures of a two-domain β-N-acetylglucosaminidase of family 3 of glycosidases, were…”
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Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB by Eicher, Thomas, Seeger, Markus A, Anselmi, Claudio, Zhou, Wenchang, Brandstätter, Lorenz, Verrey, François, Diederichs, Kay, Faraldo-Gómez, José D, Pos, Klaas M

“…Membrane transporters of the RND superfamily confer multidrug resistance to pathogenic bacteria, and are essential for cholesterol metabolism and embryonic…”
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Structural Basis of Multivalent Binding to Wheat Germ Agglutinin by Schwefel, David, Maierhofer, Caroline, Beck, Johannes G, Seeberger, Sonja, Diederichs, Kay, Möller, Heiko M, Welte, Wolfram, Wittmann, Valentin

“…The inhibition of carbohydrate−protein interactions by tailored multivalent ligands is a powerful strategy for the treatment of many human diseases. Crucial…”
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Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP by Nöll, Anne, Thomas, Christoph, Herbring, Valentina, Zollmann, Tina, Barth, Katja, Mehdipour, Ahmad Reza, Tomasiak, Thomas M., Brüchert, Stefan, Joseph, Benesh, Abele, Rupert, Oliéric, Vincent, Wang, Meitian, Diederichs, Kay, Hummer, Gerhard, Stroud, Robert M., Pos, Klaas M., Tampé, Robert

“…ABC transporters form one of the largest protein superfamilies in all domains of life, catalyzing the movement of diverse substrates across membranes. In this…”
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Structural Asymmetry of AcrB Trimer Suggests a Peristaltic Pump Mechanism by Seeger, Markus A, Schiefner, André, Eicher, Thomas, Verrey, François, Diederichs, Kay, Pos, Klaas M

“…The AcrA/AcrB/TolC complex spans the inner and outer membranes of Escherichia coli and serves as its major drug-resistance pump. Driven by the proton motive…”
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