Search Results - "Diebold, Robert B."

Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors by Woods, Keith W., Fischer, John P., Claiborne, Akiyo, Li, Tongmei, Thomas, Sheela A., Zhu, Gui-Dong, Diebold, Robert B., Liu, Xuesong, Shi, Yan, Klinghofer, Vered, Han, Edward K., Guan, Ran, Magnone, Shayna R., Johnson, Eric F., Bouska, Jennifer J., Olson, Amanda M., Jong, Ron de, Oltersdorf, Tilman, Luo, Yan, Rosenberg, Saul H., Giranda, Vincent L., Li, Qun

“…SAR studies leading from the isoquinoline analogue to the discovery of the indazole moiety are described. A series of heteroaryl-pyridine containing inhibitors…”
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Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase by Thomas, Sheela A., Li, Tongmei, Woods, Keith W., Song, Xiaohong, Packard, Garrick, Fischer, John P., Diebold, Robert B., Liu, Xuesong, Shi, Yan, Klinghofer, Vered, Johnson, Eric F., Bouska, Jennifer J., Olson, Amanda, Guan, Ran, Magnone, Shayna R., Marsh, Kennan, Luo, Yan, Rosenberg, Saul H., Giranda, Vincent L., Li, Qun

“…Based on lead compounds 2 and 3 a series of 3,5-disubstituted pyridines have been designed and evaluated for inhibition of AKT/PKB. Modifications at the 3…”
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