Search Results - "Diebel, Lawrence N."

The temporal response and mechanism of action of tranexamic acid in endothelial glycocalyx degradation by Diebel, Mark E, Martin, Jonathan V, Liberati, David M, Diebel, Lawrence N

“…The endothelial glycocalyx (GCX) plays an important role in vascular barrier function. Damage to the GCX occurs due to a variety of causes including hypoxia,…”
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Disparate effects of catecholamines under stress conditions on endothelial glycocalyx injury: An in vitro model by Martin, Jonathan V., Liberati, David M., Diebel, Lawrence N.

“…Geriatric trauma patients have high circulating norepinephrine (NE) levels but attenuated release of epinephrine (Epi) in response to increasing severity of…”
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Acute hyperglycemia increases sepsis related glycocalyx degradation and endothelial cellular injury: A microfluidic study by Diebel, Lawrence N., Liberati, David M., Martin, Jonathan V.

“…Hyperglycemia promotes vascular inflammation; however its effect on endothelial dysfunction in sepsis is unknown. Microfluidic devices (MFD) may closely mimic…”
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Tranexamic acid and the gut barrier: Protection by inhibition of trypsin uptake and activation of downstream intestinal proteases by Diebel, Mark E, Diebel, Lawrence N, Liberati, David M

“…Abstract Objective Intraluminal pancreatic trypsin and other digestive enzymes injure the gut barrier following trauma-hemorrhagic shock (T/HS). Intestinal…”
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Reinforcement of the Intestinal Mucus Layer Protects Against Clostridium difficile Intestinal Injury In Vitro by Diebel, Lawrence N., MD, FACS, Liberati, David M., MS

“…Background Clostridium difficile infection is increasing in incidence and severity. Attributable factors include virulence factors, including C difficile…”
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The effect of perturbations of the glycocalyx on microvascular perfusion in the obese trauma population: an in vitro study by Diebel, Lawrence N, Marinica, Alexander Liviu, Edelman, David, Liberati, David

“…ObjectivesPatients with morbid obesity have impaired responses to resuscitation following severe injury, which may contribute to adverse outcomes. Obesity is…”
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Phosphatidylcholine and the intestinal mucus layer: in vitro efficacy against Clostridium difficile -associated polymorphonuclear neutrophil activation by Olson, Alicia, M.D, Diebel, Lawrence N., M.D, Liberati, David M., M.S

“…Abstract Background Phosphatidylcholine (PC), an important component of intestinal mucus, protects against Clostridium difficile toxin-induced intestinal…”
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Dose-Dependent Effects of Ethanol and E. Coli on Gut Permeability and Cytokine Production by Amin, Parth B., M.D, Diebel, Lawrence N., M.D, Liberati, David M., M.S

“…Introduction The gut may prime inflammatory responses following shock/trauma insults. Ethanol (EtOH) use is common in trauma patients and may impair intestinal…”
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Pharmacologic stimulation of the nicotinic anti-inflammatory pathway modulates gut and lung injury after hypoxia-reoxygenation injury by Tarras, Samantha L., MD, Diebel, Lawrence N., MD, Liberati, David M., MS, Ginnebaugh, Kevin, BS

“…Purpose Pre-injury vagal nerve stimulation protects against gut and lung injury after experimental hemorrhagic shock (HS). This likely occurs via the…”
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H2 blockers decrease gut mucus production and lead to barrier dysfunction in vitro by Diebel, Lawrence N., MD, Liberati, David M., MS, Hall-Zimmerman, Lisa, PharmD

“…Background Pneumonia and other gut-related infectious complications have been associated with the use of histamine 2 (H2) receptor antagonists such as…”
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Effect of tranexamic acid on endothelial von Willebrand factor/ADAMTS-13 response to in vitro shock conditions by Diebel, Lawrence N., Liberati, David M.

“…Traumatic/hemorrhagic shock, sepsis and other inflammatory processes lead to endothelial activation and a loss of the endothelial glycocalyx. von Willebrand…”
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Effect of albumin solutions on endothelial oxidant injury: A microfluidic study by Diebel, Lawrence N., Liberati, David M., Carge, Michael

“…Studies have suggested a beneficial effect of early plasma-based resuscitation in patients following trauma-hemorrhagic shock. The underlying mechanism(s) are…”
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The effect of tranexamic acid dosing regimen on trauma/hemorrhagic shock-related glycocalyx degradation and endothelial barrier permeability: An in vitro model by Carge, Michael, Diebel, Lawrence N., Liberati, David M.

“…Improved outcomes with early tranexamic acid (TXA) following trauma hemorrhagic shock (T/HS) may be related to its antifibrinolytic, as well as…”
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Detection of glycocalyx degradation in real time: A conceptual model of thromboelastography by Diebel, Lawrence N., Liberati, David M., Karadjoff, Alison, Terasaki, Yusuke, Srour, Ali, McPherson, Steve

“…The endothelial glycocalyx is a critical component of the vascular barrier; its disruption after shock states may contribute to coagulopathy in a variety of…”
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The protective role of estrogen on endothelial and glycocalyx barriers after shock conditions: A microfluidic study by Diebel, Lawrence N., Wheaton, Madison, Liberati, David M.

“…Sexual dimorphism has been demonstrated after major trauma and hemorrhage shock with protective effects related to female sex or estrogen. Traumatic…”
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Plasma components to protect the endothelial barrier after shock: A role for sphingosine 1-phosphate by Diebel, Lawrence N., Liberati, David M., Hla, Timothy, Swendeman, Steven

“…Hemorrhagic shock leads to endothelial glycocalyx shedding, endothelial cellular inflammation, and increased vascular permeability. Early plasma administration…”
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Protective effects of plasma products on the endothelial-glycocalyx barrier following trauma-hemorrhagic shock: Is sphingosine-1 phosphate responsible? by Diebel, Mark E, Diebel, Lawrence N, Liberati, David M

“…Plasma is an important component of resuscitation after trauma and hemorrhagic shock (T/HS). The specific plasma proteins and the impact of storage conditions…”
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Early tranexamic acid administration ameliorates the endotheliopathy of trauma and shock in an in vitro model by Diebel, Lawrence N, Martin, Jonathan V, Liberati, David M

“…Systemic vascular endothelial injury is a consequence of trauma (T)/hemorrhagic shock (HS) which results in disturbances of coagulation, inflammation, and…”
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A biomimetic shock model on the effect of endothelial aging on vascular barrier properties by Carge, Michael J., Liberati, David M., Diebel, Lawrence N.

“…BACKGROUNDAging is characterized by a decline in cellular function, which has an adverse effect on the biologic response to injury. Both aging and…”
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Red blood cell storage and adhesion to vascular endothelium under normal or stress conditions: An in vitro microfluidic study by Diebel, Lawrence N, Liberati, David M

“…Observational studies have identified an association between duration of red blood cell (RBC) storage and adverse outcomes in trauma. Hemorrhagic shock (HS)…”
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