Search Results - "Didolkar, Varsha"

EVIDENCE FOR THE BIOACTIVATION OF ZOMEPIRAC AND TOLMETIN BY AN OXIDATIVE PATHWAY: IDENTIFICATION OF GLUTATHIONE ADDUCTS IN VITRO IN HUMAN LIVER MICROSOMES AND IN VIVO IN RATS by Chen, Qing, Doss, George A, Tung, Elaine C, Liu, Wensheng, Tang, Yui S, Braun, Matthew P, Didolkar, Varsha, Strauss, John R, Wang, Regina W, Stearns, Ralph A, Evans, David C, Baillie, Thomas A, Tang, Wei

“…Although zomepirac (ZP) and tolmetin (TM) induce anaphylactic reactions and form reactive acyl glucuronides, a direct link between the two events remains…”
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Pharmacokinetics and interactions of a novel antagonist of chemokine receptor 5 (CCR5) with ritonavir in rats and monkeys: role of CYP3A and P-glycoprotein by Kumar, Sanjeev, Kwei, Gloria Y, Poon, Grace K, Iliff, Susan A, Wang, Yanfeng, Chen, Qing, Franklin, Ronald B, Didolkar, Varsha, Wang, Regina W, Yamazaki, Masayo, Chiu, Shuet-Hing Lee, Lin, Jiunn H, Pearson, Paul G, Baillie, Thomas A

“…The mechanisms of pharmacokinetic interactions of a novel anti-human immunodeficiency virus (anti-HIV-1) antagonist of chemokine receptor 5 (CCR5)…”
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Assessment of the CYP3A-Mediated Drug Interaction Potential of Anacetrapib, a Potent Cholesteryl Ester Transfer Protein (CETP) Inhibitor, in Healthy Volunteers by Krishna, Rajesh, Bergman, Arthur J., Jin, Bo, Garg, Amit, Roadcap, Brad, Chiou, Rita, Dru, James, Cote, Josee, Laethem, Tine, Wang, Regina W., Didolkar, Varsha, Vets, Eva, Gottesdiener, Keith, Wagner, John A.

“…In this study, midazolam was used as a probe‐sensitive CYP3A substrate to investigate the effect of anacetrapib on CYP3A activity, and ketoconazole was used as…”
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Sex Hormone-Binding Globulin Mediates Prostate Androgen Receptor Action via a Novel Signaling Pathway by Ding, Victor D. H, Moller, David E, Feeney, William P, Didolkar, Varsha, Nakhla, Atif M, Rhodes, Linda, Rosner, William, Smith, Roy G

“…Estradiol (E2) and 5α-androstan-3α,17β-diol (3α-diol) have been implicated in prostate hyperplasia in man and dogs, but neither of these steroids bind to…”
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Cloning and analysis of the genes for polycyclic aromatic hydrocarbon degradation by Zylstra, G J, Wang, X P, Kim, E, Didolkar, V A

“…Bacterial degradation of polycyclic aromatic hydrocarbons initially proceeds through monooxygenase or dioxygenase attack on the aromatic ring. The…”
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