Prolyl endopeptidase and thrombin inhibitory diterpenoids from the bark of Xylopia aethiopica

The inhibitory effects of seven diterpenes, belonging to three different structural classes and isolated from the bark of Xylopia aethiopica, were investigated against the enzymes prolyl endopeptidase (PEP) and alpha-thrombin. Five compounds exhibited inhibitory activity against them.

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Bibliographic Details
Published in:	Bioscience, biotechnology, and biochemistry Vol. 69; no. 9; pp. 1763 - 1766
Main Authors:	Diderot, N.T.(University of Yaounde I (Cameroon)), Silvere, N, Yasin, A, Zareen, S, Fabien, Z, Etienne, T, Choudhary, M.I, Rahman, A.U
Format:	Journal Article
Language:	English
Published:	Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 01-09-2005 Japan Society for Bioscience Biotechnology and Agrochemistry Oxford University Press
Subjects:	Animals ANNONA SQUAMOSA Annonaceae - enzymology Anticoagulants - chemistry Anticoagulants - therapeutic use BARK Biological and medical sciences CORTEZA diterpene Diterpenes - chemistry Diterpenes - classification Diterpenes - therapeutic use DITERPENOIDE DITERPENOIDS DITERPENOS Drug Evaluation, Preclinical ECORCE enzyme inhibition Fundamental and applied biological sciences. Psychology GENERO HUMANO GENRE HUMAIN Inhibitory Concentration 50 MANKIND PEPTIDASAS PEPTIDASE PEPTIDASES Phytotherapy Plant Bark - chemistry prolyl endopeptidase Serine Endopeptidases - therapeutic use thrombin Thrombin - antagonists & inhibitors Xylopia aethiopica Serine endopeptidases Enzyme Prolyl oligopeptidase Thrombin prolyl endopeptidase Peptidases enzyme inhibition Dicotyledones Angiospermae Diterpene Xylopia aethiopica Hydrolases Spermatophyta Annonaceae Inhibition
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Description
Summary:	The inhibitory effects of seven diterpenes, belonging to three different structural classes and isolated from the bark of Xylopia aethiopica, were investigated against the enzymes prolyl endopeptidase (PEP) and alpha-thrombin. Five compounds exhibited inhibitory activity against them.
Bibliography:	S20 2006004216 F60
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.69.1763